Lifeboat Foundation

Women with Alzheimer’s disease tend to live longer than men with the disease — and a new study suggests that a gene on the X chromosome may help explain why.

Each person typically has one pair of sex chromosomes in each cell of their body. People assigned female at birth typically have two X chromosomes, while people assigned male at birth typically have one X chromosome and one Y chromosome.

Researchers say a gene called KDM6A may explain why women with Alzheimer’s disease tend to live longer than men with the same condition.

Continue reading “This Gene May Be Why Women with Alzheimer’s Disease Live Longer” »

Two groups of nerve cells may serve as “on-off switches” for male mating and aggression, suggests a new study in rodents. These neurons appear to send signals between two parts of the brain—the back tip, or posterior, of the amygdala and the hypothalamus—that together regulate emotions including fear, anxiety, and aggression.

Led by researchers at NYU Grossman School of Medicine, the study showed that male mice struggled to have sex in experiments that blocked signals from one amygdala cell group that communicates with the hypothalamus (MPN-signaling cells). When the same signals were instead bolstered, the animals were not only able to mate but would repeatedly court unreceptive females, something they would not do normally.

Similarly, when the action of a second cell group in the amygdala that also communicates with the hypothalamus (VMHvl-signaling cells) was blocked, the rodents attacked unfamiliar males half as often. When these same neurons were triggered, the mice became unusually aggressive, even attacking their female mates and familiar males.

UC Davis scientists spent years editing a sex-determining gene into bovine embryos using Crispr. In April, Cosmo arrived—and his DNA reveals how far the field has to go.

Theoretical Physicist Lawrence Krauss writes in the Wall Street Journal.

WSJ: In the 1980s, when I was a young professor of physics and astronomy at Yale, deconstructionism was in vogue in the English Department. We in the science departments would scoff at the lack of objective intellectual standards in the humanities, epitomized by a movement that argued against the existence of objective truth itself, arguing that all such claims to knowledge were tainted by ideological biases due to race, sex or economic dominance.

It could never happen in the hard sciences, except perhaps under dictatorships, such as the Nazi condemnation of “Jewish” science, or the Stalinist campaign against genetics led by Trofim Lysenko, in which literally thousands of mainstream geneticists were dismissed in the effort to suppress any opposition to the prevailing political view of the state.

:oooooo.

The battle of the sexes is a never-ending war waged within ourselves as male and female elements of our own bodies continually fight each other for supremacy. This is the astonishing implication of a pioneering study showing that it is possible to flick a genetic switch that turns female ovary cells into male testicular tissue.

For decades, the battle of the sexes has been accepted by biologists as a real phenomenon with males and females competing against each other — when their interests do not coincide — for the continued survival of their genes in the next generation. Now scientists have been able to show that a gender war is constantly raging between the genes and cells of one individual.

One of the great dogmas of biology is that gender is fixed from birth, determined by the inheritance of certain genes on the X and Y sex chromosomes. But this simplistic idea has been exploded by the latest study, which demonstrated that fully-developed adult females can undergo a partial sex change following a genetic modification to a single gene.

Continue reading “Simple gene technique changes sex of a mouse” »

In a study published on May 7, 2020, in Current Biology, researchers from University of Sydney have identified the single gene that determines how Cape honey bees reproduce without ever having sex. One gene, GB45239 on chromosome 11, is responsible for virgin births.

“It is extremely exciting,” said Professor Benjamin Oldroyd in the School of Life and Environmental Sciences. “Scientists have been looking for this gene for the last 30 years. Now that we know it’s on chromosome 11, we have solved a mystery.”

Behavioral geneticist Professor Oldroyd said: “Sex is a weird way to reproduce and yet it is the most common form of reproduction for animals and plants on the planet. It’s a major biological mystery why there is so much sex going on and it doesn’t make evolutionary sense. Asexuality is a much more efficient way to reproduce, and every now and then we see a species revert to it.”

Continue reading “Scientists Buzzing Over Virgin Birth and Genetic Mystery That’s Been Solved” »

In the future, people getting ready for a flight — and fearing impending jet lag — might fit an assortment of additions into their carry on: masks, gloves, and maybe a medicinal mushroom hailed for delivering animalistic sex drive.

That’s because a new study suggests that a synthetic form of cordycepin, a compound found in a medicinal fungus with a reputation for keeping bedroom doors closed, may help ease the pain of jet lag.

As the novel coronavirus swept through communities around the world, preying disproportionately on the poor and the vulnerable, one disadvantaged group has demonstrated a remarkable resistance. Women, whether from China, Italy or the U.S., have been less likely to become acutely ill — and far more likely to survive.

Which has made doctors wonder: Could hormones produced in greater quantities by women be at work?

Now scientists on two coasts, acting quickly on their hunches in an effort to save men’s lives, are testing the hypothesis. The two clinical trials will each dose men with the sex hormones for limited durations.

Continue reading “Can Estrogen and Other Sex Hormones Help Men Survive Covid-19?” »

The first study on vitamin D and COVID-19 was released as a preprint on April 23, and a second study was released as a preprint on April 26. Here’s what we can learn from the second study. The first study, which I reported on a few days ago, focused on disease severity, while the second one, which I’m reporting on here, focused on mortality.

The Results

The electronic health records of 780 laboratory-confirmed COVID-19 cases from the government hospitals of Indonesia between March 2 and April 24 was searched for data on vitamin D status prior to admission, age, sex, preexisting conditions, and mortality. Vitamin D status was classified as normal (≥30 ng/mL), insufficient (21−29 ng/mL), or deficient (≤20 ng/mL).

Continue reading “The Second Study on Vitamin D and COVID-19 Is Now Out” »