Lifeboat Foundation

Research suggests that a gene that governs the body’s biological (circadian) clock acts differently in males versus females and may protect females from heart disease. The study is the first to analyze circadian blood pressure rhythms in female mice. The research, published ahead of print in the American Journal of Physiology—Regulatory, Integrative and Comparative Physiology, was chosen as an APSselect article for January.

The body’s circadian clock—the biological clock that organizes bodily activities over a 24-hour period— contributes to normal variations in blood pressure and heart function over the course of the day. In most healthy humans, blood pressure dips at night. People who do not experience this temporary drop, called “non-dippers,” are more likely to develop heart disease. The circadian clock is made up of four main proteins (encoded by “clock genes”) that regulate close to half of all genes in the body, including those important for blood pressure regulation.

These results suggest that the lack of PER1 acts differently in males and females. The findings are consistent with research showing that premenopausal women are less likely to be non-dippers than men of the same age. “This study represents an important step in understanding sex differences in the regulation of cardiovascular function by the circadian clock,” the researchers wrote.

Continue reading “Gene governing body’s biological clock acts differently in males versus females” »

Power suits, robotaxis, Leonardo da Vinci mania—just a few of the things to look out for in 2019. But what else will make our top ten stories for the year ahead?

Click here to subscribe to The Economist on YouTube: https://econ.st/2xvTKdy

Continue reading “What will be the biggest stories of 2019? | Part One | The Economist” »

German scientists have found a way to determine a chick’s sex while it is still an embryo. This could help end the culling of billions of male chicks.

There’s a positive correlation of assisted reproductive technologies with arterial hypertension. Epigenetics and hormone treatments with IVF are probable causes.

Assisted reproductive technologies (ART) have been shown to induce premature vascular aging in apparently healthy children. In mice, ART-induced premature vascular aging evolves into arterial hypertension. Given the young age of the human ART group, long-term sequelae of ART-induced alterations of the cardiovascular phenotype are unknown.

This study hypothesized that vascular alterations persist in adolescents and young adults conceived by ART and that arterial hypertension possibly represents the first detectable clinically relevant endpoint in this group.

Continue reading “Association of Assisted Reproductive Technologies With Arterial Hypertension During Adolescence” »

Evolutionary genetic theory shows that genetic variation can be maintained when selection favors different versions of the same genes in males and females—an inevitable outcome of having separate sexes. That is, for many genes, there may not be a universally ‘best’ version, but rather one is best for males and one is best for females. This is known as sexually antagonistic genetic variation, but it might only be maintained under a narrow set of conditions, limiting its prevalence in nature. However, a new study by Dr. Karl Grieshop and Professor Göran Arnqvist, published in PLoS Biology, may change this view.

“One of the simplest ways for sexually antagonistic selection to maintain genetic variation in fitness is via sex-specific dominance reversal, where neither version of a gene is always dominant or recessive, but rather the version that benefits a given sex is also dominant in that sex. So whether a given version of a gene is dominant or recessive to the other will depend upon which sex it is in,” says Dr. Karl Grieshop.

So far, robots have primarily been developed to fulfill utilitarian purposes, assisting humans or serving as tools to facilitate the completion of particular tasks. As robots become more human-like, however, this could pose significant challenges, particularly for robots built to engage with humans socially.

Humans have used sex dolls as inanimate objects for sexual pleasure throughout history. Animated sex robots, social robots created to meet humans’ needs for sex and affection, offer more. Due to recent developments in robotics and AI, sex robots are now becoming more advanced and human-like. Purchasers can have them customised both in appearance and in how they speak and behave to simulate intimacy, warmth and emotion.

Currently, sex robots are inanimate things, able to simulate but not engage in mutual intimacies. In the future, however, technological advances might allow researchers to manufacture sentient, self-aware sex robots with feelings, or sexbots. The implications of the availability of sexbots as customisable perfect partners for intimate relationships with humans are potentially vast.

Continue reading “Research explores the ethical implications of creating sentient and self-aware sexbots” »

An elusive medical advance might finally be within grasp, one that could make some couples’ sex lives a lot more convenient. This week, researchers officially kicked off the first wide-scale clinical trial of a male contraceptive topical gel.

The trial, funded by the National Institute of Child Health and Human Development (NICHD), is set to enroll 420 relatively healthy and young couples. The couples will be recruited from nine different study sites in seven countries scattered across the globe, including Chile, England, and Sweden. But the first batch of volunteers will come from sites in the U.S. in Seattle, California, and Kansas.

Healthy mice have been born from same-sex parents in China. To investigate the ways that mammalian reproduction differs from other animals, researchers at the Chinese Academy of Sciences used stem cells and genetic manipulation to produce 29 live, healthy offspring from two female mice. The pups have since grown to adulthood and had babies of their own.

It’s offering 80 minutes alone with a robotic sex doll.

Some say the proliferation of sex robots could lead to less demand for prostitution, but not all agree.