Lifeboat Foundation: Safeguarding Humanity
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Category: sex – Page 19

Universe Today.

Space may be pretty, but it’s dangerous. Astronauts face a much higher dose of ionizing radiation than us Earth-bound folks, and a new report says that NASA’s current guidelines and risk assessment methods are in serious need of an update.

On the surface of the Earth, protected by our extensive magnetic field and layers of thick atmosphere, we experience about 2–3 milliSieverts (mSv) of radiation exposure every year. Even that background level is enough to trigger the occasional cancer growth.

But astronauts, especially those hoping to go on upcoming long-term missions to the Moon and Mars, face a much greater risk due to the high-energy, ionizing radiation constantly soaking every cubic centimeter of space. To mitigate that risk, NASA currently implements a system based on “risk of exposure-induced death” (REID). The space agency estimates the exposure for each astronaut based on their sex, and if the REID exceeds 3%, their spacefaring careers are over.

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This video explains x-linked traits/sex linked traits and thomas hunt morgan experiment.

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There are Sirt6 activators on the market, but since we are not seeing any major news about results I would question their value.

SPONSOR: Longevity. Technology — https://www.longevity.technology/?utm_source=SSS&utm_medium=…aign=Sirt6

Sirtuins are highly conserved proteins that are involved in a variety of important cellular processes such as DNA repair, metabolism and circadian rhythms. The mammalian sirtuins (SIRT1-7) are a family of proteins that carry out NAD+-dependent protein deacylation and mono-ADP-ribosylation. These modifications on proteins can influence their stability, localisation within a cell and activity.

In the late 90s interest in sirtuins bloomed as it was found yeast lived 30% longer when they had an additional copy of a yeast sirtuin, Sir2. Similar studies have now been performed in mice, but whilst overexpression of SIRT1 in mice does not result in lifespan extension, overexpression of SIRT6 does. This has led to SIRT6 being referred to as the longevity sirtuin. However, there seems to be some sex-and mouse strain-dependent differences. So, in the remainder of the video, we will discuss what you need to know about SIRT6 including it’s proposed cellular activities, it’s association with longevity and how SIRT6 activation using allosteric activators could have future therapeutic potential.

TIMESTAMPS:

Continue reading “The longevity sirtuin – what you need to know about SIRT6” | >

Wines and table grapes exist thanks to a genetic exchange so rare that it’s only happened twice in nature in the last 6 million years. And since the domestication of the grapevine 8000 years ago, breeding has continued to be a gamble.

When today’s growers cultivate new varieties – trying to produce better-tasting and more disease-resistant grapes – it takes two to four years for breeders to learn whether they have the genetic ingredients for the perfect flower.

Females set fruit, but produce sterile pollen. Males have stamens for pollen, but lack fruit. The perfect flower, however, carries both sex genes and can self-pollinate. These hermaphroditic varieties generally yield bigger and better-tasting berry clusters, and they’re the ones researchers use for additional cross-breeding.

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Skin aging is a multifactorial process consisting of two distinct and independent mechanisms: intrinsic and extrinsic aging. Youthful skin retains its turgor, resilience and pliability, among others, due to its high content of water. Daily external injury, in addition to the normal process of aging, causes loss of moisture. The key molecule involved in skin moisture is hyaluronic acid (HA) that has unique capacity in retaining water. There are multiple sites for the control of HA synthesis, deposition, cell and protein association and degradation, reflecting the complexity of HA metabolism. The enzymes that synthesize or catabolize HA and HA receptors responsible for many of the functions of HA are all multigene families with distinct patterns of tissue expression. Understanding the metabolism of HA in the different layers of the skin and the interactions of HA with other skin components will facilitate the ability to modulate skin moisture in a rational manner.

Keywords: hyaluronic acid, hyaluronic acid synthases, hyaluronidases, CD44, RHAMM, skin aging.

Human skin aging is a complex biological process, not yet fully understood. It is the result of two biologically independent processes. The first is intrinsic or innate aging, an unpreventable process, which affects the skin in the same pattern as it affects all internal organs. The second is extrinsic aging, which is the result of exposure to external factors, mainly ultraviolet (UV) irradiation, that is also referred to as photoaging.1 Intrinsic skin aging is influenced by hormonal changes that occur with age,2 such as the gradual decreased production of sex hormones from the mid-twenties and the diminution of estrogens and progesterone associated with menopause. It is well established that the deficiency in estrogens and androgens results in collagen degradation, dryness, loss of elasticity, epidermal atrophy and wrinkling of the skin.3

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Males may have shorter lifespans than females due to repetitive sections of the Y chromosome that create toxic effects as males get older. These new findings appear in a study by Doris Bachtrog of the University of California, Berkeley published April 22 in PLOS Genetics.

In humans and other species with XY sex chromosomes, females often live longer than . One possible explanation for this disparity may be repetitive sequences within the genome. While both males and females carry these repeat sequences, scientists have suspected that the large number of repeats on the Y chromosome may create a “toxic y effect” that shortens males’ lives. To test this idea, Bachtrog studied male fruit flies from the species Drosophila miranda, which have about twice as much repetitive DNA as and a shorter lifespan. They showed that when the DNA is in its tightly packed form inside the cells of young male flies, the repeat sections are turned off. But as the flies age, the DNA assumes a looser form that can activate the repeat sections, resulting in .

The new study demonstrates that Y chromosomes that are rich in repeats are a genomic liability for males. The findings also support a more general link between repeat DNA and aging, which currently, is poorly understood. Previous studies in have shown that when repeat sections become active, they impair memory, shorten the lifespan and cause DNA damage. This damage likely contributes to aging’s physiological effects, but more research will be needed to uncover the mechanisms underlying repeat DNA’s .

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One in 17 people will suffer from a rare disease at some time in their lives. Most of these rare diseases have a genetic cause and often affect children, but proving which gene change causes a disease is a huge challenge.

Scientists have discovered a new genetic disease, which causes some children’s brains to develop abnormally, resulting in delayed intellectual development and often early onset cataracts.

The majority of patients with the condition, which is so new it doesn’t have a name yet, were also microcephalic, a birth defect where a baby’s head is smaller than expected when compared to babies of the same sex and age.

Researchers from the universities of Portsmouth and Southampton found that changes in a gene called coat protein complex 1 (COPB1) caused this rare genetic disease.

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Here’s my latest video!

In November 2020, I made a HDL video based on a meta-analysis in ~3.4 million subjects that was published in July 2020. In Dec 2020, a larger study (n=15.8 million subjects) was published-those data are presented in the video, and compared against the meta-analysis.

In addition, I’ve tested my HDL 2 more times since November 2020, so how’s my progress for getting it into the optimal range? Also, I attempt to derive clinical significance by identifying correlations for higher HDL with lower Lp(a) and hs-CRP.

Studies referenced in the video:
High-density lipoprotein cholesterol and all-cause mortality by sex and age: a prospective cohort study among 15.8 million adults:
https://pubmed.ncbi.nlm.nih.gov/33313654/

HDL-C is associated with mortality from all causes, cardiovascular disease and cancer in a J-shaped dose-response fashion: a pooled analysis of 37 prospective cohort studies:

Continue reading “HDL Update: Age-Related Changes, All-Cause Mortality Risk, And Progress Towards The Optimal Range” | >

The Moon and Mars are remote and forbidding but it’s fairly easy to turn their soil into construction material and mine it for water to drink and oxygen to breathe.

Several astronauts have spent more than a year in zero gravity, and they experienced muscle loss, brittle bones and difficulties with vision. A space station could be spun up to ameliorate these problems, and for colonists on the Moon and Mars, gravity would be reduced, not absent. Their capillaries and cardiovascular systems would adjust, and muscle mass would be shed.

Few of us would relish living in the isolation and close confines of a bubble habitat far from home. The lack of a varied natural environment is likely to lead to weaker immune systems. However, the colonists will innovate in the activities of exercise and sex. Their space suits will be made from materials that are supple, supportive and skin-tight, and we might envy their ability to effortlessly leap and cavort across the surfaces of their new worlds.

If early colonies are restocked with new recruits from Earth, physiological changes will be modest. But subsequent waves of colonists may sever the umbilical; they might be dissidents or motivated by utopian ideals. As they live and die off-Earth, their psychological landscape will be sculpted by their new environment. Biologically, they will evolve into a new offshoot from the human tree.

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