Toggle light / dark theme

The SARS-CoV-2 virus mutates fast. That’s a concern because these more transmissible variants of SARS-CoV-2 are now present in the U.S., U.K. and South Africa and other countries, and many people are wondering whether the current vaccines will protect the recipients from the virus. Furthermore, many question whether we will we be able to keep ahead of future variants of SARS-CoV-2, which will certainly arise.

In my laboratory I study the molecular structure of RNA viruses – like the one that causes COVID-19 – and how they replicate and multiply in the host. As the virus infects more people and the pandemic spreads, SARS-CoV-2 continues to evolve. This process of evolution is constant and it allows the virus to sample its environment and select changes that make it grow more efficiently. Thus, it is important to monitor viruses for such new mutations that could make them more deadly, more transmissible or both.

Did you know, getting a bit cold from time to time can help you get fitter, live longer, reduce pain and discomfort and help you concentrate and feel great?
Whether it is cold showers, ice baths, swimming in open water or trying out cryotherapy, enduring the cold is becoming increasingly popular as a way to hack your body as an aid to longevity and a good health span.
And for a good reason.
It effects metabolism, heart rate, blood pressure and many biomarkers.
It improves pain tolerance and levels, your mood and energy levels.
It effects mitochondrial biogenesis and brown fat stores, even beiging previously white adipose tissue.
In fact, there are hardly any systems left untouched.
But it does have side effects as well, especially for those who have health issues, but they also have the most to gain.
If you want to get more detail then check out this video where I go into more depth looking at the subject and discuss the studies that have been done to assess the effects.
Have a great day.


In Cold Showers Pros And Cons — And Other Cold Therapies, I will be looking at the good, and the bad, when it comes to embracing cold therapies from cold water swimming and ice baths, through to cold showers and cryotherapy.

What are they all about?
How do they work?
Do they even work?
Are they dangerous?

If you want to know the answer to these and more then just watch this video.

And after yo have finished, why not try this one about the benefits of saunas… https://youtu.be/dTwOMjWnzhg As always the studies that I mentioned are linked here… ECT overview https://www.mayoclinic.org/tests-proc… view of treatment Electroconvulsive Therapy for Depression: A Review of the Quality of ECT versus Sham ECT Trials and Meta-Analyses https://connect.springerpub.com/conte… Scientific Evidence-Based Effects of Hydrotherapy on Various Systems of the Body https://www.ncbi.nlm.nih.gov/pmc/arti… Plasma Renin study https://www.ncbi.nlm.nih.gov/pmc/arti… Effects of long-term whole-body cold exposures on plasma concentrations of ACTH, beta-endorphin, cortisol, catecholamines and cytokines https://pubmed.ncbi.nlm.nih.gov/18382… Human physiological responses to immersion into water of different temperatures https://link.springer.com/article/10… The effects of exercise and cold exposure on mitochondrial biogenesis in skeletal muscle and white adipose tissue https://www.ncbi.nlm.nih.gov/pmc/arti… Cold and Exercise: Therapeutic Tools to Activate Brown Adipose Tissue and Combat Obesity https://www.ncbi.nlm.nih.gov/pmc/arti… Cold-induced vasoconstriction may persist long after cooling ends: an evaluation of multiple cryotherapy units https://www.ncbi.nlm.nih.gov/pmc/arti

Forever we have held a view that AGING, DISEASE & DEATH is an un-alterable eventuality, those who dared question were ostracised for playing God.

If you choose to look deeper you will surely be amazed. Bowhead whales live for over 200 yrs “Turriptosis Dohnri” is a Jellyfish that lives forever. Can these #genetics traits be replicated in humans? Could the removal of #senescence #cells that accelerates aging be the answer Is it even possible to control or reverse aging? Can we grow old healthily? 150000 die every day & over 100000 of them are caused by aging.

Catch Joao Pedro de Magalhaes microbiologist at Centaura & founder at Magellan Science Ltd. share his insights on the science of #humanlongevity #gerontology.

Change Transform INDIA-CHANGE I M POSSIBLE is a podcast & a platform for the brave Disruptors who don’t conform to the convention. subscribe, support & share India’s 1st #futuretech #podcast #agereversal #reverseaging #longevity #immortality #science


Joao Pedro Magalhaes is a Professor at the University of Liverpool in England.

It is true. From its effect on biomarkers such as heat shock proteins and Fox 03, through to real world impacts on cardiovascular health, to improving mood, helping you live longer healthier and reducing your chance of dying before your time. I think we all know saunas are really great for you, but this will give you all the scientific reasons why… Taking it easy and relaxing for half an hour… Is not just wasting your time… Changes today will make tomorrow better. #saunas


I am going to give you the best reasons in the world to sit back and take it easy in a nice warm environment, and to just forget the troubles of the world.
Maybe play some music, or a podcast, or listen to a book, or just meditate, just relax and take it easy.
It is for your own health after all!!

How about clicking here and watching the video I did on good and bad stress.

The science in the video.

Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons.

Although no list like this can be definitive, we polled dozens of researchers over the past year to develop a diverse line-up of ten software tools that have had a big impact on the world of science. You can weigh in on our choices at the end of the story.


From Fortran to arXiv.org, these advances in programming and platforms sent biology, climate science and physics into warp speed.

Almost a year ago, we were told by our governments and healthcare professionals that a two-week shutdown of the economy would “flatten the curve.”


The Chinese Coronavirus (COVID-19) hit American shores — officially, anyway, there is significant evidence that it arrived earlier — in late January 2020. The American public was then told that a two-week shutdown of the economy would “flatten the curve,” relieving the pressure on hospital intensive care units and saving lives in the long run.

The average American, including conservatives, being people of good faith, complied, thinking that this was a common-sense measure that would save lives in the wake of a new and mysterious pandemic.

But two things quickly happened: First, the goalposts moved. No longer was it enough to “flatten the curve.” Now we were to be locked down until there was a cure.

On Januray 25th, we will discuss different aspects of longtermism — a concept of effective altruism. To decide which ist the best action to take we usually consider the effects of our actions on the short-or medium-term future — whether we save someone’s life, or mitigate sexism or racism in the next generation. According to longtermism that is wildly mistaken. The value of our actions is determined almost exclusively by their effects on the future in the very long-run — the next millions and billions of years. Their effects on the next 100 or even 1000 years are just about irrelevant. Our everyday thinking is radically short-sighted, and common evaluations perhaps dramatically wrong. In this online meetup, we will look at a compelling justification for longtermism, at its historical roots, and some of its practical implications — e.g. concerning existential risks, or the idea that our time might be the most important in the history of humanity. Free discord session on 9:30 — 11:30 AM PST 11:30 — 13:30 AM DST.


What is the best action we can take? According to longtermism we should consider the effects on the future in the very long run — the next millions and billions of years — to answer this question.