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Spiros Michalakis is the Caltech quantum physicist who served as the science advisor on Bill & Ted: Face The Music and he was kind enough to sit down and chat about quantum physics, the nature of time, and the brilliant minds behind Bill & Ted.

Check out IQIM at http://www.iqim.caltech.edu

Here’s the video featuring Paul Rudd playing chess with Stephen Hawking:

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NASA’s Mars rovers have been one of the great scientific and space successes of the past two decades.

Four generations of rovers have traversed the red planet gathering , sending back evocative photographs, and surviving incredibly harsh conditions—all using on-board computers less powerful than an iPhone 1. The latest , Perseverance, was launched on July 30, 2020, and engineers are already dreaming of a future generation of rovers.

While a major achievement, these missions have only scratched the surface (literally and figuratively) of the planet and its geology, geography, and atmosphere.

There is no question that motivation is one of the hardest and yet important factors in life. It’s the difference between success and failure, goal-setting and aimlessness, well-being and unhappiness. And yet, why is it so hard to get motivated — or even if we do, to keep it up?

That is the question that scientists led by Professor Carmen Sandi at EPFL and Dr Gedi Luksys at the University of Edinburgh have sought to answer. The researchers worked off previous knowledge that told them two things: First, that people differ a lot in their capacity to engage in motivated behavior and that motivational problems like apathy are common in neurodegenerative and psychiatric disorders. Second, to target an area of the brain called the “nucleus accumbens”.

Sitting close to the bottom of brain, the nucleus accumbens has been the subject of a lot of research. The reason is that it was quickly found to be a major player in functions like aversion, reward, reinforcement, and motivation.

Dozens of times over the last decade NASA scientists have launched laser beams at a reflector the size of a paperback novel about 240,000 miles (385,000 kilometers) away from Earth. They announced today, in collaboration with their French colleagues, that they received signal back for the first time, an encouraging result that could enhance laser experiments used to study the physics of the universe.

The NASA scientists aimed for is mounted on the Lunar Reconnaissance Orbiter (LRO), a spacecraft that has been studying the moon from its orbit since 2009. One reason engineers placed the reflector on LRO was so it could serve as a pristine target to help test the reflecting power of panels left on the moon’s surface about 50 years ago. These older reflectors are returning a , which is making it harder to use them for science.

Scientists have been using reflectors on the moon since the Apollo era to learn more about our nearest neighbor. It’s a fairly straightforward experiment: Aim a at the reflector and clock the amount of time it takes for the light to come back. Decades of making this one measurement has led to major discoveries.

NSD2 is the fourth protective factor of cellular senescence that our team has identified,” said Professor Mitsuyoshi Nakao. “With the discovery that NSD2 protects against cellular senescence, this study clarifies a basic mechanism of aging.


Researchers from Kumamoto University in Japan have used comprehensive genetic analysis to find that the enzyme NSD2, which is known to regulate the actions of many genes, also works to block cell aging. Their experiments revealed 1) inhibition of NSD2 function in normal cells leads to rapid senescence and 2) that there is a marked decrease in the amount of NSD2 in senescent cells. The researchers believe their findings will help clarify the mechanisms of aging, the development of control methods for maintaining NSD2 functionality, and age-related pathophysiology.

As the cells of the body continue to divide (cell reproduction), their function eventually declines and they stop growing. This cellular senescence is an important factor in health and longevity. Cell aging can also be stimulated when genomic DNA is damaged by physical stress, such as radiation or ultraviolet rays, or by chemical stress that occurs with certain drugs. However, the detailed mechanisms of aging are still unknown. Cell aging can be beneficial when a cell becomes cancerous; it prevents malignant changes by causing cellular senescence. On the other hand, it makes many diseases more likely with age. It is therefore important that cell aging is properly controlled.

Although senescent cells lose their proliferative ability, it has recently become clear that senescent cells secrete various proteins that act on surrounding cells to promote chronic inflammation and cancer development. Since senescent cells are more active than expected, cellular aging is thought to be responsible for whole body aging. This idea has been supported by reports of systemic aging suppression in aged mice after removal of accumulated senescent cells. In other words, if you can control cell aging, you may be able to control the progression of aging throughout the body.

Materials science researchers, led by electrical engineering professor Shui-Qing “Fisher” Yu, have demonstrated the first electrically injected laser made with germanium tin.

Used as a semiconducting material for circuits on , the could improve micro-processing speed and efficiency at much lower costs.

In tests, the laser operated in pulsed conditions up to 100 kelvins, or 279 degrees below zero Fahrenheit.