Lifeboat Foundation: Safeguarding Humanity
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Category: science – Page 137

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Fear of scientists “playing god” is at the centre of many a plot line in science fiction stories. Perhaps the latest popular iteration of the story we all love is Jurassic World (2015), a film I find interesting only for the tribute it paid to the original Michael Crichton novel and movie Jurassic Park.

Full op-ed from h+ Magazine on 7 October 2015 http://hplusmagazine.com/2015/10/07/opinion-synthetic-biolog…f-mankind/

john hammond jurrasic parkIn Jurassic Park, a novel devoted to the scare of genetic engineering when biotech was new in the 1990s, the character of John Hammond says:

“Would you make products to help mankind, to fight illness and disease? Dear me, no. That’s a terrible idea. A very poor use of new technology. Personally, I would never help mankind.”

What the character is referring to is the lack of profit in actually curing diseases and solving human needs, and the controversy courted just by trying to get involved in such development. The goal to eradicate poverty or close the wealth gap between rich and poor nations offers no incentive for a commercial company.

Instead, businesses occupy themselves with creating entertainment, glamour products and perfume, new pets, and other superfluities that biotech can inevitably offer. This way, the companies escape not only moral chastisement for failing to share their technology adequately or make it freely available, but they can also attach whatever price tag they want without fear of controversy.

It is difficult for a well-meaning scientist or engineer to push society towards greater freedom and equality in a single country. It is even harder for such a professional to effect a great change over the whole world or improve the human condition the way transhumanists, for example, have intended.

Although discovery and invention continue to stun us all on an almost daily basis, such things do not happen as quickly or in as utilitarian a way as they should. And this lack of progress is deliberate. As the agenda is driven by businessmen who adhere to the times they live in, driven more by the desire for wealth and status than helping mankind, the goal of endless profit directly blocks the path to abolish scarcity, illness and death.

Today, J. Craig Venter’s great discoveries of how to sequence or synthesize entire genomes of living biological specimens in the field of synthetic biology (synthbio) represent a greater power than the hydrogen bomb. It is a power we must embrace. In my opinion, these discoveries are certainly more capable of transforming civilization and the globe for the better. In Life at the Speed of Light(2013), that is essentially Venter’s own thesis.

And contrary to science fiction films, the only threat from biotech is that humans will not adequately and quickly use it. Business leaders are far more interested in profiting from people’s desire for petty products, entertainment and glamour than curing cancer or creating unlimited resources to feed civilization. But who can blame them? It is far too risky for someone in their position to commit to philanthropy than to stay a step ahead of their competitors.

Even businessmen who later go into philanthropy do very little other than court attention in the press and polish the progressive image of the company. Of course, transitory deeds like giving food or clean water to Africans will never actually count as developing civilization and improving life on Earth, when there are far greater actions that can be taken instead.

It is conspicuous that so little has been done to develop the industrial might of poor countries, where schoolchildren must still live and study without even a roof over their heads. For all the unimaginable destruction that our governments and their corporate sponsors unleash on poor countries with bombs or sanctions when they are deemed to be threatening, we see almost no good being done with the same scientific muscle in poor countries. Philanthropists are friendly to the cause of handing out food or money to a few hungry people, but say nothing of giving the world’s poor the ability to possess their own natural resources and their own industries.

Like our bodies, our planet is no longer a sufficient vehicle for human dreams and aspirations. The biology of the planet is too inefficient to support the current growth of the human population. We face the prospect of eventually perishing as a species if we cannot repair our species’ oft-omitted disagreements with nature over issues of sustainability, congenital illness and our refusal to submit to the cruelties of natural selection from which we evolved.

Once we recognize that the current species are flawed, we will see that only by designing and introducing new species can suffering, poverty and the depletion of natural resources be stopped. Once we look at this option, we find already a perfect and ultimately moral solution to the threats of climate change, disease, overpopulation and the terrible scarcity giving rise to endless injustice and retaliatory terrorism.

The perfect solution could only be brought to the world by a heroic worker in the fields of biotech and synthetic biology. Indeed, this revolution may already be possible today, but fear is sadly holding back the one who could make it happen.

Someone who believes in changing the human animal with technology must believe in eradicating poverty, sickness and injustice with technology. For all our talk of equality and human rights in our rhetoric, the West seems determined to prevent poorer countries from possessing their own natural resources. A right guaranteed by the principles of modernization and industrialization, which appears to have been forgotten. Instead, we prefer to watch them being nursed by the richer countries’ monopolies, technology, and workers who are there cultivating, extracting, refining, or buying all their resources for them.

So, quite contrary to the promises of modernity, we have replaced the ideal of the industrialization of poor states with instead the vision of refugee camps, crude water wells, and food aid delivered by humanitarian workers to provide only temporary relief. In place of a model of development that was altruistic and morally correct, we instead glorify the image of non-Westerners as primitives who are impossible to help yet still we try.

The world’s poor have become not the focus of attention aimed at helping humanity, but props for philanthropists to make themselves look noble while doing nothing to truly help them. What we should turn to is not a return to the failed UN development agendas of the 1970s, which were flawed, but a new model entirely, and driven by people instead of governments and UN agencies.

It is high time that we act to help mankind altruistically, rather than a select few customers. The engineers and scientists of the world need to abandon the search for profit, if only for a moment. We should call on them to turn their extraordinary talent to the absolute good of abolishing poverty and scarcity. If they do not do this, we will talk about direct action to break free the scientific gifts they refused to share.

We live in courageous times. These are times of whistle-blowers, lone activists for the truth, and lone scientist-entrepreneurs who must be praised even if our profit-driven culture stifles their great works. And although we live in courageous times, we seem not yet brave enough to take real action to overcome the human disaster.

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Synthetic biology image from https://www.equipes.lps.u-psud.fr/TRESSET/research8.html

(A) Enclosure of three red-fluorescent 200-nm spheres inside a “giant” liposome labeled with DiO. A wideband ultraviolet excitation filter was used for the simultaneous observation of these two differently stained species. Images were digitally postprocessed to balance the colors and to adjust their brightness at an equal level. (B) Trajectories of the particles. They were free to move but did not pass through the membrane. © GFP entrapped by a “giant” liposome. To get rid of noncaptured proteins, the solution was filtered by dialysis in such a way that the fluorescence background level became negligible with respect to the liposome interior. (D) Fluorescence photographs of λ-DNA-loaded liposome. λ-DNA was stained with SYBR Green, while DiI (red emission) was incorporated to liposome membrane. Liposome was observed through a narrow-band blue excitation filter (suitable for SYBR Green). (E) Same as previously with a wideband green excitation filter (suitable for DiI). Because of a low fluorescence response, part D was digitally enhanced in terms of brightness and contrast. In comparison, part E was darkened to present a level similar to part D. These pictures were taken at an interval of ~1 s, just the time to switch the filters. (E) Fluorescence picture of λ-DNA-loaded liposomes. Green dots stand for λ-DNA molecules, and lipids are labeled in red. A wideband blue excitation filter was used for this bicolor imaging, and a high-sensitivity color CCD camera captured it. [Anal. Chem. 77 (2005) 2795]

Maybe we can convince the Chinese to start funding our space program.

On Monday, Chinese scientist Youyou Tu was jointly awarded the Nobel Prize in Physiology or Medicine for her discovery of a new malaria therapy. It was remarkable research in its own right, but equally significant is the fact that Tu is the first scientist to ever be awarded a Nobel Prize for work done at a Chinese institution — despite the fact that the country trains more scientists and engineers than any other nation on Earth.

In fact, China now spends more money on research and development than Europe, and by 2020, it’s predicted to outspend the US, as Nature editor Ed Gerstner wrote last month in Research Information. But despite that investment, there’s a big reason for why Chinese science has lagged behind other parts of the world — it has a long history of pumping out dodgy research.

It’s no secret that Chinese scientists have faked fossil records, pushed the boundaries of gene editing in humans, and have frequently been involved in peer review scams. The extent of fraud has been called “endemic” by a Chinese researcher, and a 2010 study of 32,000 Chinese scientists backed this up, revealing that 55 percent knew someone guilty of academic fraud.

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[From Engadget]…

While NASA has already shown us Pluto’s best images yet, the administration is anything but done blowing our minds. What you see above is an enhanced high-resolution color view of Pluto, created with a combination of blue, red and infrared images. NASA says this photo, taken by New Horizons spacecraft, highlights Pluto’s diverse landforms and shows us its complex geological and climatological story — as much as scientists have been able to figure out, anyway. Over the past few months, NASA’s shared many things related to Pluto, including a closer look at its desolate surface and icy mountain range.

Aristotle is frequently regarded as one of the greatest thinkers of antiquity. So why didn’t he think much of his brain?

In this brief history of the brain, the GPA explores what the great minds of the past thought about thought. And we discover that questions that seem to have obvious answers today were anything but self-evident for the individuals that first tackled them. And that conversely, sometimes the facts which we simply accept to be true can be blinding, preventing us from making deeper discoveries about our our world and ourselves.

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“Previous studies of the galactic habitable zone have been concerned with identifying those regions of the Galaxy that may favor the emergence of complex life. A planet is deemed habitable if it meets a set of assumed criteria for supporting the emergence of such complex life. In this work, we extend the assessment of habitability to consider the potential for life to further evolve to the point of intelligence—termed the propensity for the emergence of intelligent life, φI.”

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challenge-banner-website

“Now in its 8th annual cycle with the strongest applicant pool yet, including the most diverse pool of program entrants to date creating change in 136 countries, The Fuller Challenge remains the only award specifically working to identify and catalyze individuals and teams employing a whole systems approach to problem solving.”

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3045

“It has sold millions of copies, is perhaps the greatest novel in the science-fiction canon and Star Wars wouldn’t have existed without it. Frank Herbert’s Dune should endure as a politically relevant fantasy from the Age of Aquarius.”

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July, 2015; as you know.. was the all systems go for the CERNs Large Hadron Collider (LHC). On a Saturday evening, proton collisions resumed at the LHC and the experiments began collecting data once again. With the observation of the Higgs already in our back pocket — It was time to turn up the dial and push the LHC into double digit (TeV) energy levels. From a personal standpoint, I didn’t blink an eye hearing that large amounts of Data was being collected at every turn. BUT, I was quite surprised to learn at the ‘Amount’ being collected and processed each day — About One Petabyte.

Approximately 600 million times per second, particles collide within the (LHC). The digitized summary is recorded as a “collision event”. Physicists must then sift through the 30 petabytes or so of data produced annually to determine if the collisions have thrown up any interesting physics. Needless to say — The Hunt is On!

The Data Center processes about one Petabyte of data every day — the equivalent of around 210,000 DVDs. The center hosts 11,000 servers with 100,000 processor cores. Some 6000 changes in the database are performed every second.

With experiments at CERN generating such colossal amounts of data. The Data Center stores it, and then sends it around the world for analysis. CERN simply does not have the computing or financial resources to crunch all of the data on site, so in 2002 it turned to grid computing to share the burden with computer centres around the world. The Worldwide LHC Computing Grid (WLCG) – a distributed computing infrastructure arranged in tiers – gives a community of over 8000 physicists near real-time access to LHC data. The Grid runs more than two million jobs per day. At peak rates, 10 gigabytes of data may be transferred from its servers every second.

By early 2013 CERN had increased the power capacity of the centre from 2.9 MW to 3.5 MW, allowing the installation of more computers. In parallel, improvements in energy-efficiency implemented in 2011 have led to an estimated energy saving of 4.5 GWh per year.

Image: CERN

PROCESSING THE DATA (processing info via CERN)> Subsequently hundreds of thousands of computers from around the world come into action: harnessed in a distributed computing service, they form the Worldwide LHC Computing Grid (WLCG), which provides the resources to store, distribute, and process the LHC data. WLCG combines the power of more than 170 collaborating centres in 36 countries around the world, which are linked to CERN. Every day WLCG processes more than 1.5 million ‘jobs’, corresponding to a single computer running for more than 600 years.

Racks of servers at the CERN Data Centre (Image: CERN)

CERN DATA CENTER: The server farm in the 1450 m2 main room of the DC (pictured) forms Tier 0, the first point of contact between experimental data from the LHC and the Grid. As well as servers and data storage systems for Tier 0 and further physics analysis, the DC houses systems critical to the daily functioning of the laboratory. (Image: CERN)

The data flow from all four experiments for Run 2 is anticipated to be about 25 GB/s (gigabyte per second)

  • ALICE: 4 GB/s (Pb-Pb running)
  • ATLAS: 800 MB/s – 1 GB/s
  • CMS: 600 MB/s
  • LHCb: 750 MB/s

In July, the LHCb experiment reported observation of an entire new class of particles:
Exotic Pentaquark Particles (Image: CERN)

Possible layout of the quarks in a pentaquark particle. The five quarks might be tightly bound (left). The five quarks might be tightly bound. They might also be assembled into a meson (one quark and one anti quark) and a baryon (three quarks), weakly bound together.

The LHCb experiment at CERN’s LHC has reported the discovery of a class of particles known as pentaquarks. In short, “The pentaquark is not just any new particle,” said LHCb spokesperson Guy Wilkinson. “It represents a way to aggregate quarks, namely the fundamental constituents of ordinary protons and neutrons, in a pattern that has never been observed before in over 50 years of experimental searches. Studying its properties may allow us to understand better how ordinary matter, the protons and neutrons from which we’re all made, is constituted.”

Our understanding of the structure of matter was revolutionized in 1964 when American physicist Murray Gell-Mann proposed that a category of particles known as baryons, which includes protons and neutrons, are comprised of three fractionally charged objects called quarks, and that another category, mesons, are formed of quark-antiquark pairs. This quark model also allows the existence of other quark composite states, such as pentaquarks composed of four quarks and an antiquark.

Until now, however, no conclusive evidence for pentaquarks had been seen.
Earlier experiments that have searched for pentaquarks have proved inconclusive. The next step in the analysis will be to study how the quarks are bound together within the pentaquarks.

“The quarks could be tightly bound,” said LHCb physicist Liming Zhang of Tsinghua University, “or they could be loosely bound in a sort of meson-baryon molecule, in which the meson and baryon feel a residual strong force similar to the one binding protons and neutrons to form nuclei.” More studies will be needed to distinguish between these possibilities, and to see what else pentaquarks can teach us!

August 18th, 2015
CERN Experiment Confirms Matter-Antimatter CPT Symmetry
For Light Nuclei, Antinuclei (Image: CERN)

Days after scientists at CERN’s Baryon-Antibaryon Symmetry Experiment (BASE) measured the mass-to-charge ratio of a proton and its antimatter particle, the antiproton, the ALICE experiment at the European organization reported similar measurements for light nuclei and antinuclei.

The measurements, made with unprecedented precision, add to growing scientific data confirming that matter and antimatter are true mirror images.

Antimatter shares the same mass as its matter counterpart, but has opposite electric charge. The electron, for instance, has a positively charged antimatter equivalent called positron. Scientists believe that the Big Bang created equal quantities of matter and antimatter 13.8 billion years ago. However, for reasons yet unknown, matter prevailed, creating everything we see around us today — from the smallest microbe on Earth to the largest galaxy in the universe.

Last week, in a paper published in the journal Nature, researchers reported a significant step toward solving this long-standing mystery of the universe. According to the study, 13,000 measurements over a 35-day period show — with unparalleled precision – that protons and antiprotons have identical mass-to-charge ratios.

The experiment tested a central tenet of the Standard Model of particle physics, known as the Charge, Parity, and Time Reversal (CPT) symmetry. If CPT symmetry is true, a system remains unchanged if three fundamental properties — charge, parity, which refers to a 180-degree flip in spatial configuration, and time — are reversed.

The latest study takes the research over this symmetry further. The ALICE measurements show that CPT symmetry holds true for light nuclei such as deuterons — a hydrogen nucleus with an additional neutron — and antideuterons, as well as for helium-3 nuclei — two protons plus a neutron — and antihelium-3 nuclei. The experiment, which also analyzed the curvature of these particles’ tracks in ALICE detector’s magnetic field and their time of flight, improve on the existing measurements by a factor of up to 100.

IN CLOSING..

A violation of CPT would not only hint at the existence of physics beyond the Standard Model — which isn’t complete yet — it would also help us understand why the universe, as we know it, is completely devoid of antimatter.

UNTIL THEN…

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