Proteins sustain life as we know it, serving many important structural and functional roles throughout the body. But these large molecules have cast a long shadow over a smaller subclass of proteins called microproteins.

Joint research led by Sosuke Ito of the University of Tokyo has shown that nonequilibrium thermodynamics, a branch of physics that deals with constantly changing systems, explains why optimal transport theory, a mathematical framework for the optimal change of distribution to reduce cost, makes generative models optimal. As nonequilibrium thermodynamics has yet to be fully leveraged in designing generative models, the discovery offers a novel thermodynamic approach to machine learning research. The findings were published in the journal Physical Review X.
Image generation has been improving in leaps and bounds over recent years: a video of a celebrity eating a bowl of spaghetti that represented the state of the art a couple of years ago would not even qualify as good today. The algorithms that power image generation are called diffusion models, and they contain randomness called “noise.”
During the training process, noise is introduced to the original data through diffusion dynamics. During the generation process, the model must eliminate the noise to generate new content from the noisy data. This is achieved by considering the time-reversed dynamics, as if playing the video in reverse. One piece of the art and science of building a model that produces high-quality content is specifying when and how much noise is added to the data.
Both groups showed significant reductions in anxiety levels. The control group receiving traditional therapy had a 45% reduction on the Hamilton scale and a 50% reduction on the Beck scale, compared to 30% and 35% reductions in the chatbot group. While the chatbot provided accessible, immediate support, traditional therapy proved more effective due to the emotional depth and adaptability provided by human therapists. The chatbot was particularly beneficial in crisis settings where access to therapists was limited, proving its value in scalability and availability. However, its emotional engagement was notably lower compared to in-person therapy.
The Friend chatbot offers a scalable, cost-effective solution for psychological support, particularly in crisis situations where traditional therapy may not be accessible. Although traditional therapy remains more effective in reducing anxiety, a hybrid model combining AI support with human interaction could optimize mental health care, especially in underserved areas or during emergencies. Further research is needed to improve AI’s emotional responsiveness and adaptability.
Background The increasing demand for psychotherapy and limited access to specialists underscore the potential of artificial intelligence (AI) in mental health care. This study evaluates the effectiveness of the AI-powered Friend chatbot in providing psychological support during crisis situations, compared to traditional psychotherapy. Methods A randomized controlled trial was conducted with 104 women diagnosed with anxiety disorders in active war zones. Participants were randomly assigned to two groups: the experimental group used the Friend chatbot for daily support, while the control group received 60-minute psychotherapy sessions three times a week. Anxiety levels were assessed using the Hamilton Anxiety Rating Scale and Beck Anxiety Inventory. T-tests were used to analyze the results. Results Both groups showed significant reductions in anxiety levels.
#ArtificialIntelligence #CyberSecurity #QuantumComputing
The transformative effects of emerging technologies in this year by artificial intelligence and quantum computing will be hugely impactful; however, their cybersecurity challenges on society will require the need for proactive security adaptation and collaboration to mitigate new threats.
Fable, a San Francisco-based startup, has created a new streaming service called Showrunner, which is touted as «Netflix with AI». Its main feature is that viewers can create scenes or entire episodes for TV shows from scratch — using simple text prompts for artificial intelligence. The idea may seem dubious, but a tech giant like Amazon believed in the project’s potential and invested an undisclosed amount in Fable and the development of streaming.
Showrunner currently operates in closed alpha version with 10,000 users (another 100,000 are on the waiting list) and offers two original «shows» — storyworlds with characters that users can direct into different narrative arcs.
The first, titled «Exit Valley», is described as a «Family Guy-style television comedy set in Sim-Francisco, poking fun at artificial intelligence leaders Sam Altman, Elon Musk, and others». Second, «Everything Is Fine», in which a husband and wife have a big fight while going to Ikea, and then are transported to a world where they are actually divorced and have to find each other.
Researchers at Microsoft tried to determine which precise jobs are most and least likely to be replaced by generative AI — and the results are bad news for anyone currently enjoying the perks of a cushy desk job.
As detailed in a yet-to-be-peer-reviewed paper, the Microsoft team analyzed a “dataset of 200k anonymized and privacy-scrubbed conversations between users and Microsoft Bing Copilot,” and found that the occupations most likely to be made obsolete by the tech involve “providing information and assistance, writing, teaching, and advising.”
The team used the data to come up with an “AI applicability score,” an effort to quantify just how vulnerable each given occupation is, taking into consideration how often AI is already being used there and how successful those efforts have been.
How does your brain decide where to store a brand-new piece of information—like a new face, word, or concept? In this video, we’ll explore a working neural circuit that demonstrates how cortical columns could be allocated dynamically and efficiently—using real spikes, real timing, and biologically realistic learning rules. Instead of vague theories or abstract algorithms, we’ll show a testable mechanism that selects the first available cortical column in just 5 milliseconds, highlighting the incredible speed and parallelism of the brain. This is a crucial first step in building intelligence from the ground up—one circuit at a time.
Useful links:
The Future AI Society: https://futureaisociety.org.
The Brain Simulator III (UKS) project: https://github.com/FutureAIGuru/BrainSimIII
The Brain Simulator II (Neural Simulator) project: https://github.com/FutureAIGuru/BrainSimII
Overview Video: https://youtu.be/W2uauk2bFjs.
More Details Video: https://youtu.be/6po1rMFZkik.
How the UKS Learns Video: https://youtu.be/Rv0lrem3lVs.