Deep learning models have proved to be highly promising tools for analyzing large numbers of images. Over the past decade or so, they have thus been introduced in a variety of settings, including research laboratories.

In the field of biology, deep learning models could potentially facilitate the quantitative analysis of microscopy images, allowing researchers to extract meaningful information from these images and interpret their observations. Training models to do this, however, can be very challenging, as it often requires the extraction of features (i.e., number of cells, area of cells, etc.) from microscopy images and the manual annotation of training data.

Researchers at CERVO Brain Research Center, the Institute for Intelligence and Data, and Université Laval in Canada have recently developed an artificial neural network that could perform in-depth analyses of microscopy images using simpler, image-level annotations. This model, dubbed MICRA-Net (MICRoscopy Analysis neural network), was introduced in a paper published in Nature Machine Intelligence.

Machine learning techniques are designed to mathematically emulate the functions and structure of neurons and neural networks in the brain. However, biological neurons are very complex, which makes artificially replicating them particularly challenging.

Researchers at Korea University have recently tried to reproduce the complexity of biological neurons more effectively by approximating the function of individual neurons and synapses. Their paper, published in Nature Machine Intelligence, introduces a network of evolvable neural units (ENUs) that can adapt to mimic specific neurons and mechanisms of synaptic plasticity.

“The inspiration for our paper comes from the observation of the complexity of biological neurons, and the fact that it seems almost impossible to model all of that complexity produced by nature mathematically,” Paul Bertens, one of the researchers who carried out the study, told TechXplore. “Current artificial neural networks used in deep learning are very powerful in many ways, but they do not really match biological neural network behavior. Our idea was to use these existing artificial neural networks not to model the entire brain, but to model each individual neuron and synapse.”

Evolution, the process by which living organisms adapt to their surrounding environment over time, has been widely studied over the years. As first hypothesized by Darwin in the mid 1800s, research evidence suggests that most biological species, including humans, continuously adapt to new environmental circumstances and that this ultimately enables their survival.

In recent years, researchers have been developing advanced computational techniques based on artificial neural networks, which are architectures inspired by biological neural networks in the human brain. Models based on artificial neural networks are trained to optimize millions of synaptic weights over millions of observations in order to make accurate predictions or classify data.

Researchers at Princeton University have recently carried out a study investigating the similarities and differences between artificial and biological neural networks from an evolutionary standpoint. Their paper, published in Neuron, compares the evolution of biological neural networks with that of artificial ones using psychology theory.