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Using nanopore single-molecule sensing to identify glycans

Glycans perform varied and crucial functions in numerous cellular activities. The diverse roles of glycans are matched by their highly complex structures, which derive from differences in composition, branching, regio-and stereochemistry, and modification. This incomparable structural diversity is challenging to the structural analysis of glycans.

Recently, a joint research group led by Prof. Qing Guangyan and Prof. Liang Xinmiao from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS) has developed a identification method based on single-molecule sensing through a glycan derivatization strategy. The study was published in Nature Communications on March 28.

Identifying and sequencing glycans using nanopore single-molecule techniques has sparked interest; however, it has achieved little progress over the past dozen years. Only a handful of cases that focused on either high molecular weight polysaccharides or some monosaccharides were reported.

Dr. Kathryn Huff, Ph.D. — Assistant Secretary, Office of Nuclear Energy, U.S. Department of Energy

Advancing Nuclear Energy Science And Technology For U.S. Energy, Environmental And Economic Needs — Dr. Katy Huff, Ph.D. — Assistant Secretary, U.S. Department of Energy Office of Nuclear Energy, U.S. Department of Energy.


Dr. Kathryn Huff, Ph.D. (https://www.energy.gov/ne/person/dr-kathryn-huff) is Assistant Secretary, Office of Nuclear Energy, U.S. Department of Energy, where she leads their strategic mission to advance nuclear energy science and technology to meet U.S. energy, environmental, and economic needs, both realizing the potential of advanced technology, and leveraging the unique role of the government in spurring innovation.

Prior to her current role, Dr. Huff served as a Senior Advisor in the Office of the Secretary and also led the office as the Principal Deputy Assistant Secretary for Nuclear Energy.

Before joining the Department of Energy, Dr. Huff was an Assistant Professor in the Department of Nuclear, Plasma, and Radiological Engineering at the University of Illinois at Urbana-Champaign where she led the Advanced Reactors and Fuel Cycles Research Group. She was also a Blue Waters Assistant Professor with the National Center for Supercomputing Applications.

Dr. Huff was previously a Postdoctoral Fellow in both the Nuclear Science and Security Consortium and the Berkeley Institute for Data Science at the University of California — Berkeley. She received her PhD in Nuclear Engineering from the University of Wisconsin-Madison and her undergraduate degree in Physics from the University of Chicago. Her research focused on modeling and simulation of advanced nuclear reactors and fuel cycles.

Experiment demonstrates continuously operating optical fiber made of thin air

Great, until the mention of “directed energy”…


Researchers at the University of Maryland (UMD) have demonstrated a continuously operating optical fiber made of thin air.

The most common optical fibers are strands of glass that tightly confine light over long distances. However, these fibers are not well-suited for guiding extremely high-power beams due to glass damage and scattering of laser energy out of the fiber. Additionally, the need for a physical support structure means that glass fiber must be laid down long in advance of light signal transmission or collection.

Howard Milchberg and his group in UMD’s Departments of Physics and Electrical & Computer Engineering and Institute for Research in Electronics & Applied Physics have demonstrated an optical guiding method that beats both limitations, using auxiliary ultrashort laser pulses to sculpt fiber optic waveguides in the air itself.

From Theory to Reality: A Groundbreaking Manifestation of Interdependent Networks in a Physics Lab

New findings enable experimental studies to control and further develop the multiscale phenomena of complex interdependent materials.

Bar-Ilan University researchers Havlin and Frydman have demonstrated the “network of networks” theory using a controlled system of interdependent superconducting networks. The study confirms that coupled networks exhibit abrupt transitions under varying temperatures, validating Havlin’s 2010 theory. This groundbreaking research has significant implications across physics, materials science, and device applications, potentially leading to new developments in self-healing systems, sensitive sensors, and network metamaterials.

Metamaterials are engineered materials that have properties not usually found in nature.

6 Physics Breakthroughs Predicted During Your Lifetime | Unveiled

The future of physics is very bright indeed! Join us, and find out more!

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In this video, Unveiled takes a closer look at the most exciting ways that physics will change the world during YOUR lifetime! We’re now SO CLOSE to making these incredible breakthroughs, but which will happen first? And which will have the greatest impact on life, the universe, and everything?

This is Unveiled, giving you incredible answers to extraordinary questions!

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6 Scientific Breakthroughs Predicted For Your Lifetime — https://youtu.be/wGKj-3AfxdE
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Godel & Einstein | Einstein walked with Gödel | Kurt Gödel | Incompleteness theorem | Logic

This video is about the story of two geniuses, Albert Einstein and the famous logician Kurt Godel. It is about their meeting at IAS, Princeton, New Jersey, when they both walked and discussed many things. For Godel, Einstein was his best friend and till his last days, he remain close to Einstein. Their nature was opposite to each other, yet both of them were very good friends. What did they talk about with each other? What did they share? What were their thoughts? For Godel, Einstein was more like his guide and for Einstein, it was a great pleasure to walk with him.

In the first episode, we discover their first meeting with each other and the development of friendship between them.

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Physicists Discover a Strange New Theoretical Phase of Hydrogen

This new solid hydrogen phase discovered by an international team of researchers followed the model’s presentation of hydrogen molecules under extreme conditions: to use a food analogy, their shape morphed from spheres stacked like a pile of oranges to something that more closely resembled eggs.

Hydrogen typically requires very low temperatures and very high pressures to form a solid. It was through a novel machine learning study of this particular phase change that the scientists came across the new molecular arrangement.