May 8, 2023

Using nanopore single-molecule sensing to identify glycans

Posted by in categories: chemistry, physics

Glycans perform varied and crucial functions in numerous cellular activities. The diverse roles of glycans are matched by their highly complex structures, which derive from differences in composition, branching, regio-and stereochemistry, and modification. This incomparable structural diversity is challenging to the structural analysis of glycans.

Recently, a joint research group led by Prof. Qing Guangyan and Prof. Liang Xinmiao from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS) has developed a identification method based on single-molecule sensing through a glycan derivatization strategy. The study was published in Nature Communications on March 28.

Identifying and sequencing glycans using nanopore single-molecule techniques has sparked interest; however, it has achieved little progress over the past dozen years. Only a handful of cases that focused on either high molecular weight polysaccharides or some monosaccharides were reported.

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