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A Closer Look At What A Stem Cell Is: Our Cells’ Diverse Regenerative Capabilities

For several decades now, one of the buzz words in the medical field has been ‘stem cell’. It has been said to aid in treating illnesses like multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer’s disease, and heart diseases.

For the past three years, researchers at the Hubrecht Institute in the Netherlands have been painstakingly cataloging and mapping all the proliferating cells found in mouse hearts, looking for cardiac stem cells. The elusive cells should theoretically be able to repair damaged heart muscle, so the stakes in finding them have been high.

This week, however, Proceedings of the National Academy of Sciences is scheduled to announce the results of the Hubrecht team’s work: no evidence of cardiac stem cells at all.

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Injection to halt the progress of Alzheimer’s ‘available within decade’

An injection capable of halting the progress of Alzheimer’s could be available to patients within a decade, Britain’s leading dementia organisation predicts.

The Alzheimer’s Society says a series of recent breakthroughs in treatments that disrupt harmful genes has brought scientists to a “tipping point” in their fight against the disease.

For decades, researchers have sought without success a treatment for Alzheimer’s based on targeting damaging proteins that build up in the brain.

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Synaptic protein regulates anxiety behaviour

Anxiety disorders are severe mental disorders in which patients suffer from intense fears and anxiety or from sudden, inexplicable panic attacks. In extreme cases, the affected individuals barely leave their homes, which can have serious consequences for their relationships with family and friends as well as for their professional lives. Scientists at the Max Planck Institute for Experimental Medicine in Göttingen have now identified a synaptic protein which, when inactivated, has an anxiolytic effect in mice.

Around 10 percent of the population suffer from , and current treatment options only offer effective help for a proportion of those affected. One of the changes observed in the brains of patients with disorders is an increased neuronal activity in the amygdala, a brain region that plays a key role in processing emotions such as anxiety or fear. An overactivation of the amygdala is thought to be involved in causing exaggerated anxiety. Many anxiolytic medications such as benzodiazepines presumably normalize this overactivation by strengthening the function of inhibitory synapses.

Synapses are connections between nerve cells in the brain, at which information is transmitted from one nerve cell to another. At inhibitory synapses, this transmission results in a reduction in the activity of the neighbouring nerve cells. In the amygdala, for instance, this inhibits the transmission of stimuli that trigger fear and anxiety. Benzodiazepines strengthen this —but unfortunately they affect not only those inhibitory synapses that transmit anxiogenic stimuli but also many other inhibitory synapses in the brain. This can lead to significant side effects such as pronounced sedation and impaired concentration. Accordingly, scientists are searching for new, more specific targets for anxiolytic medications.

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Chinese researchers identify new risk gene for Alzheimer’s disease

BEIJING, Dec. 28 (Xinhua) — A Chinese research group has identified a gene variant that plays a key role in the development of Alzheimer’s disease in Han Chinese, the largest ethnic group in China.

The study was recently published by the National Science Review, an English journal affiliated with the Chinese Academy of Sciences (CAS).

Alzheimer’s disease (AD) is an irreversible, progressive brain disorder that slowly destroys memory, thinking skills and the ability to carry out simple tasks. The disease affects about 48 million people worldwide, and the number is expected to increase with the aging population. There is no effective cure.

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The Surprising Relativism of the Brain’s GPS

Physics grappled with the question of whether space is absolute or relative for centuries, before deciding in favor of relativity. But, it is only in recent years that the brain sciences have begun to discuss a parallel set of questions. For many years now, absolute space has ruled neuroscience. In the visual system, for example, it has long been assumed that there are two channels of information flow.4 The first is the “what” channel, carrying information about the identity of objects that an animal sees. The second is the “where” channel, containing information about the absolute position of these objects. It was believed that the “what” channel contained no positional information at all. However, recent work has shown that while no information about the absolute position of an object is present in this channel, there is relative position information.5,6 This relative positional information is likely to be very important for object recognition.


The first pieces of the brain’s “inner GPS” started coming to light in 1970. In the laboratories of University College London, John O’Keefe and his student Jonathan Dostrovsky recorded the electrical activity of neurons in the hippocampus of freely moving rats. They found a group of neurons that increased their activity only when a rat found itself in a particular location. They called them “place cells.”

Building on these early findings, O’Keefe and his colleague Lynn Nadel proposed that the hippocampus contains an invariant representation of space that does not depend on mood or desire. They called this representation the “cognitive map.” In their view, all of the brain’s place cells together represent the entirety of an animal’s environment, and whichever place cell is active indicates its current location. In other words, the hippocampus is like a GPS. It tells you where you are on a map and that map remains the same whether you are hungry and looking for food or sleepy and looking for a bed. O’Keefe and Nadel suggested that the absolute position represented in the hippocampal place cells provides a mental framework that can be used by an animal to find its way in any situation—be that to find food or a bed.

Over the next 40 years, other researchers—including the husband and wife duo of Edvard and May-Britt Moser—produced support for the idea that the brain’s hippocampal circuitry acts like an inner GPS. In recognition of their pioneering work, O’Keefe and the Mosers were awarded the 2014 Nobel Prize in physiology or medicine. You’d think that this would mean that the role of the hippocampus in guiding an animal through space was solved.


Your Brain Is Constantly Searching for Problems to Fix

Why do many problems in life seem to stubbornly stick around, no matter how hard people work to fix them? It turns out that a quirk in the way human brains process information means that when something becomes rare, we sometimes see it in more places than ever.

Think of a “neighborhood watch” made up of volunteers who call the police when they see anything suspicious. Imagine a new volunteer who joins the watch to help lower crime in the area. When they first start volunteering, they raise the alarm when they see signs of serious crimes, like assault or burglary.

Let’s assume these efforts help and, over time, assaults and burglaries become rarer in the neighborhood. What would the volunteer do next? One possibility is that they would relax and stop calling the police. After all, the serious crimes they used to worry about are a thing of the past.

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Stephen Hawking’s Final Theory About Our Universe Will Melt Your Brain

Nope. Too late already. It’s been molten long ago already ha…


Groundbreaking physicist Stephen Hawking left us one last shimmering piece of brilliance before he died: his final paper, detailing his last theory on the origin of the Universe, co-authored with Thomas Hertog from KU Leuven.

The paper, published in the Journal of High Energy Physics in May, puts forward that the Universe is far less complex than current multiverse theories suggest.

It’s based around a concept called eternal inflation, first introduced in 1979 and published in 1981.

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