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Category: neuroscience – Page 929

Perhaps you read the stories last week (including the NYT piece linked to below) about the researchers at Johns Hopkins, led by Gul Dolen, who gave ecstasy (MDMA) to octopuses and found that they, like humans, became more social on the drug. Dr. Dolen talked about using the octopus as a model organism in neuroscience research during last Friday’s day-long workshop hosted by the NIH BRAIN 2.0 working group.

By dosing the tentacled creatures with MDMA, researchers found they share parts of an ancient messaging system involved in social behaviors with humans.

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Searching for a more direct connection between the gut and the brain, researchers were shocked to see that distance spanned by a single synapse, relaying the signal in less than 100 milliseconds, less than the blink of an eye. The finding has profound implications for the understanding of appetite and appetite suppressants, most of which target slow-acting hormones rather than fast-acting synapses.

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DeepMind is providing more research to show how neuroscience can inspire more sophisticated AI.

There’s a cognitive quirk humans have that seems deceptively elementary. For example: every morning, you see a man in his 30s walking a boisterous collie. Then one day, a white-haired lady with striking resemblance comes down the street with the same dog.

Subconsciously we immediately make a series of deductions: the man and woman might be from the same household. The lady may be the man’s mother, or some other close relative. Perhaps she’s taking over his role because he’s sick, or busy. We weave an intricate story of those strangers, pulling material from our memories to make it coherent.

This ability—to link one past memory with another—is nothing but pure genius, and scientists don’t yet understand how we do it. It’s not just an academic curiosity: our ability to integrate multiple memories is the first cognitive step that lets us gain new insight into experiences, and generalize patterns across those encounters. Without this step, we’d forever live in a disjointed world.

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Physicists face the same hard problem as neuroscientists do: the problem of bridging objective description and subjective experience. Physics has encountered consciousness. Quantum theory says an object remains in a superposition of possibilities until observed. We can consider a quantum state as being about our knowledge rather than a direct description of physical reality. The physics of information just may be that bridging of quantum-to-digital reality of subjective experience. We are now at the historic juncture when quantum computing could reveal quantum information processing underpinnings of subjectivity. Quantum mechanics is a spectacularly successful theory of fundamental physics that allows us to make probabilistic predictions derived from its mathematical formalism, but the theory doesn’t tell us precisely how these probabilities should be interpreted in regards to phenomenology, i.e. our experiential reality. There are basically three main interpretive camps within quantum mechanics from which stem at least a dozen further interpretations.

By Alex Vikoulov.

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“A quantum possibility is more real than a classical possibility, but less real than a classical reality.” –Boris Tsirelson.

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Highly specialized cartilage is characteristically avascular and non-neural in composition with low cell numbers in an aliphatic environment. Despite its apparent simplicity, bioengineering regenerative hyaline cartilage in a form effective for implantation remains challenging in musculoskeletal tissue engineering. Existing surgical techniques including autologous chondrocyte implantation (ACI) and matrix-induced autologous chondrocyte implantation (MACI) are considered superior to self-repair induction techniques. However, both MACI and ACI are complex, multistage procedures that require a double operation; first for surgical excision of native cartilage, followed by expansion of adult chondrocytes in vitro prior to implantation by a second operation.

Regenerating robust articular hyaline-like cartilage is a key priority in musculoskeletal tissue engineering to prevent cost-intensive degenerative osteoarthritis that limits the quality of life in global healthcare. Integrating mesenchymal stem cells and 3D printing technologies has shown significant promise in bone tissue engineering– although the key challenge remains in transferring the bench-based technology to the operating room for real-time applications. To tackle this, a team of Australian orthopedic surgeons and bioengineers collaboratively proposed an in situ additive manufacturing technique for effective cartilage regeneration. The handheld engineered extrusion device known as the BioPen offers an advanced, co-axial extrusion strategy to deposit cells embedded in a hydrogel material within a surgical setting.

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