Lifeboat Foundation

A remarkable new study has successfully used the CRISPR-Cas9 gene editing technique to edit a specific gene in mice engineered to have fragile X syndrome (FXS), a single-gene disorder often related to autism. The single gene edit in the live mice resulted in significant improvements in repetitive and obsessive behaviors, making this the first time gene editing has been used to effectively target behavioral symptoms related to autism spectrum disorder (ASD).

FXS is a genetic disorder associated with intellectual disability, seizures and exaggerated repetitive behavior. Previous studies have shown that the repetitive behaviors associated with FXS are related to a specific excitatory receptor in the brain that, when dysregulated, causes exaggerated signaling between cells.

The CRISPR technique homes in on the gene that controls that excitatory receptor, the metabotropic glutamate receptor 5 (mGluR5), and essentially disables it, dampening the excessive signaling the corresponds with repetitive behaviors. In mice treated with the new system, obsessive digging behavior was reduced by 30 percent and repetitive leaping actions dropped by 70 percent.

For the first time ever researchers have had a breakthrough in creating a cocktail of drugs that caused new neurons to grow in the brains of mice.

In my last article I gave a detailed account on the debate of neurogenesis. While some neuroscientists claim that neurogenesis takes place within the adult mammalian human brain other researchers contest that idea claiming that new neurons stop developing at a very young age. Whichever side of the debate you are on one thing remains certain, that there are neurological diseases that leave negative impacts on cognitive function. This has left researchers looking for various ways to treat Alzheimer’s, Parkinson’s, and other brain damage.

Continue reading “Experimental Drug Injection Causes the Brain to Grow New Neurons” »

We have a ‘thirst for knowledge’ but sometime ‘ignorance is bliss’, so how do we choose between these two mind states at any given time?

UCL psychologists have discovered our brains use the same algorithm and neural architecture to evaluate the opportunity to gain information, as it does to evaluate rewards like food or money.

Funded by the Wellcome Trust, the research, published in the Proceedings of the National Academy of Sciences, also finds that people will spend money to both obtain advance knowledge of a good upcoming event and to remain ignorant of an upcoming bad event.

Studies of massive genetic databases may lead to new therapies for mental disorders.

Why do our brains — and the brains of other animals — have so many folds?

Compare an analog and a digital audio recording medium. VHS video tape — an analog medium — stores a continuous curve of modulated audio/visual information. In a digital CD continuous audio is sliced into 44,100 frames a second, and represented by discrete numbers.

On playback the sounds are presented as continuous, much as the individual still frames of a motion picture appear continuous when played back fast enough. Most people can’t hear the difference between digital and analog recordings, me included, but those who say they do may spend thousands on turntables and tube amps to get the full analog experience.

From measurements, we know that neuron currents are continuous, not step functions. The important question is how is the information represented by these signals? Most psychological research assumes continuous or analog representation, but in the lengthy paper Is Information in the Brain Represented in Continuous or Discrete Form? James Tee and Desmond Taylor of the University of Canterbury make a strong theoretical and experimental case for digital data.

Continue reading “Is your brain an analog or digital device? New research surprises” »

Ever watch ‘Your Brain on Blank’? Ever have a question about the brain? Then you’re in the right place. Join us as neuroscience Ph.D. candidate Shannon Odell takes a few minutes to answer some of the write-in questions from our viewers about how different stimuli affect your brain.

Experiments in mice have shown for the first time that bacteria found in the gut of babies and children seem to play a role in brain development.

Scientists used stem cells to grow a miniature model of a Neanderthal’s brain for the first time. The tiny blob of neurons reveals what makes us different.