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Category: neuroscience – Page 810

How Exercise Creates Super-Brains

We all know that exercise is good for our health. But besides lowering the risk of obesity or type II diabetes, exercise has also been shown to benefit our brain. More precisely, exercise modifies parts of the brain and improves memory, attention and improves mood. Regular exercise further lowers the risk to suffer from dementia or depression. But how does exercise benefit our brains?

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Philosophers have speculated for centuries that exercise promotes our brain functionality but only a few decades ago, scientists uncovered that this is true. Studies have shown that children who are more athletic perform better in creativity, concentration, maths verbal and IQ tests. These children also tend to have a larger hippocampus and basal ganglia both of which are important for memory and attention span. Adults who started to workout regularly also have changes in their brain and perform better in various tests. There are several mechanisms which explain this phenomenon. When we exercise, brain cells release VEGF which helps to supply the brain with oxygen. Moreover, neurotrophins are released when we workout which helps the survival of brain cells. Exercise also seems to improve neuroplasticity through the same pathways. Since exercise leads to the release of neurotransmitters such as serotonin, workouts also have been used to treat mental disorders such as depression. In various studies it was seen exercise helps to alleviate the symptoms of people who suffer from major depression.
The literature suggests roughly 150 minutes of moderate-intensity exercise or 75 minutes of vigorous-intensity exercise per week might be optimal to curb the risk of heart disease and 19 other chronic diseases. Concerning brain health, 120 minutes of moderate exercise a week might be enough to get all the benefits we have seen before. But even if you do less you might see a difference in the long run. In general, aerobic exercise seemed to have the best impacts on your brain. Jogging, running, swimming and all other forms of aerobic sports might give the benefits we have seen in this video!

References:
https://www.nature.com/articles/s41591-018-0275-4
https://www.pnas.org/doi/abs/10.1073/pnas.0905307106
https://pubmed.ncbi.nlm.nih.gov/20693803/
https://www.sciencedirect.com/science/article/abs/pii/S0025619616300477
https://www.frontiersin.org/articles/10.3389/fpsyg.2019.02658/full.
https://ajp.psychiatryonline.org/doi/pdf/10.1176/ajp.2007.164.2.350a.
https://www.health.harvard.edu/blog/regular-exercise-changes
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702700/pdf/nihms117644.pdf.
https://stanford.library.sydney.edu.au/archives/spr2020/entr
stPhilSpor.
https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00762/full.
https://journals.sagepub.com/doi/full/10.1177/23259671211001129
https://www.frontiersin.org/articles/10.3389/fpsyg.2018.00509/full.
https://www.cdc.gov/nccdphp/dnpao/features/physical-activity-brain-health/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943756/pdf/main.pdf.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457513/pdf/ncomms15557.pdf.
https://positivepsychology.com/exercise-neurological-benefits/

00:00–00:53 Intro.

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Scientists discover a rare neurological disease involving cellular recycling

The new disease could provide insights into how the cell’s recycling system contributes to a healthy brain. Researchers at the National Institutes of Health have discovered a new neurological condition characterized by issues with motor coordination and speech. They identified three children with the condition, two siblings and an unrelated child.

Adults, Children Do Not Experience Time in the Same Way; Here’s Why

While time may be a worldwide constant, it can be quite tricky. Several individuals have felt like childhood summers were extremely long in comparison to how they experience the same 3 months as adults. Though individuals can argue about time perception and the factors that dilate and compress time, it is possible to look into it experimentally.

Time Perception Is Different For Adults and Children

A team of researchers proceeded to do just that. According to Neuroscience News, the scientists looked into how eventfulness impacts estimates of duration across various cognitive development milestones.

Fighting brain cancer with bioadhesive nanoparticles

A team of researchers from Yale and the University of Connecticut (UConn) has developed a nanoparticle-based treatment that targets multiple culprits in glioblastoma, a particularly aggressive and deadly form of brain cancer.

The results are published in Science Advances (“Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy”).

A new treatment developed by Yale researchers uses bioadhesive nanoparticles that adhere to the site of the tumor and then slowly release the synthesized peptide nucleic acids that they’re carrying. In this image, the nanoparticles (red) are visible within human glioma tumor cells (green with blue nuclei). (Image: Yale Cancer Center)

Nanotechnology meets Neuroscience — Nicholas Melosh at BrainMind

Dr. Nick Melosh at the BrainMind Summit hosted at Stanford, interviewed by BrainMind member Christian Bailey.

Nick Melosh is a Professor of Materials Science and Engineering, Stanford University. Nick’s research at Stanford focuses on how to design new inorganic structures to seamlessly integrate with biological systems to address problems that are not feasible by other means. This involves both fundamental work such as to deeply understand how lipid membranes interact with inorganic surfaces, electrokinetic phenomena in biologically relevant solutions, and applying this knowledge into new device designs. Examples of this include “nanostraw” drug delivery platforms for direct delivery or extraction of material through the cell wall using a biomimetic gap-junction made using nanoscale semiconductor processing techniques. We also engineer materials and structures for neural interfaces and electronics pertinent to highly parallel data acquisition and recording. For instance, we have created inorganic electrodes that mimic the hydrophobic banding of natural transmembrane proteins, allowing them to ‘fuse’ into the cell wall, providing a tight electrical junction for solid-state patch clamping. In addition to significant efforts at engineering surfaces at the molecular level, we also work on ‘bridge’ projects that span between engineering and biological/clinical needs. My long history with nano-and microfabrication techniques and their interactions with biological constructs provide the skills necessary to fabricate and analyze new bio-electronic systems.”

Learn more about BrainMind: https://brainmind.org/
Apply to BrainMind: https://brainmind.org/application

Scientists Transplant Human Brain Organoids Into Adult Rats — And They Respond to Visual Stimuli

In a study published in the journal Cell Stem Cell on February 2, researchers show that brain organoids—clumps of lab-grown neurons—can integrate with rat brains and respond to visual stimulation like flashing lights.

Decades of research has shown that we can transplant individual human and rodent neurons into rodent brains, and, more recently, it has been demonstrated that human brain organoids can integrate with developing rodent brains. However, whether these organoid grafts can functionally integrate with the visual system of injured adult brains has yet to be explored.

“We focused on not just transplanting individual cells, but actually transplanting tissue,” says senior author H. Isaac Chen, a physician and Assistant Professor of Neurosurgery at the University of Pennsylvania. “Brain organoids have architecture; they have structure that resembles the brain. We were able to look at individual neurons within this structure to gain a deeper understanding of the integration of transplanted organoids.”

Neuroscientist investigates social cognition in biased juries

Bias in juries pose a serious challenge for judges and attorneys to conduct fair, equal and impartial trials. A recent paper published in Social Cognitive and Affective Neuroscience considers the overlap between social cognitive processes such as cultural and racial stereotyping and brain activity associated with bias against defendants accused of severe crimes.

R. McKell Carter, one of the paper’s co-authors, is an assistant professor of psychology and neuroscience at the University of Colorado Boulder. He is an expert on : the processes of the brain that interpret the actions, intentions and expectations of others.

Carter’s study examines the role of social cognition in crime-type , when jurors perceive the prosecutor’s case stronger based on the severity of the charges against the defendant. Using imaging (fMRI) scans on mock jurors, researchers mapped out regions of the brain that activated when jurors were presented with fictional case narratives and evidence.

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