Our eyes are continuously bombarded by an enormous amount of visual information – millions of shapes, colors, and ever-changing motion all around us.
For the brain, this is no easy feat.
On the one hand, the visual world alters continuously because of changes in light, viewpoint, and other factors. On the other, our visual input constantly changes due to blinking and the fact that our eyes, head, and body are frequently in motion.
The Neuro-Network.
𝐇𝐨𝐰 ‘𝐃𝐨𝐫𝐦𝐚𝐧𝐭’ 𝐂𝐞𝐥𝐥𝐬 𝐈𝐧 𝐓𝐡𝐞 𝐀𝐠𝐢𝐧𝐠 𝐁𝐫𝐚𝐢𝐧 𝐂𝐨𝐧𝐭𝐫𝐢𝐛𝐮𝐭𝐞 𝐓𝐨 𝐂𝐨𝐠𝐧𝐢𝐭𝐢𝐯𝐞 𝐃𝐞𝐜𝐥𝐢𝐧𝐞
𝘾𝙤𝙜𝙣𝙞𝙩𝙞𝙫𝙚 𝙙𝙚𝙘𝙡𝙞𝙣𝙚 𝙖𝙣𝙙 𝙛𝙤𝙧𝙜𝙚𝙩𝙩𝙞𝙣𝙜 𝙩𝙝𝙞𝙣𝙜𝙨 𝙖𝙨 𝙬𝙚 𝙜𝙚𝙩 𝙤𝙡𝙙𝙚𝙧 𝙞𝙨 𝙖𝙡𝙢𝙤𝙨𝙩 𝙖 𝙧𝙞𝙜𝙝𝙩 𝙤𝙛 𝙥𝙖𝙨𝙨𝙖𝙜𝙚. 𝘼𝙡𝙡… See more.
Cellular senescence is a state where cells get stuck in a particular phase of their cell cycle, which can affect physiological function. In the brain this effect can block neuroregeneration. Clearing them may reverse certain aspects of cognitive decline associated with aging, including memory loss.
What are biomarkers? They are medical signals that can measure health in an accurate and reproducible way. Common examples include blood pressure readings, heart rate, and even genetic test results.
Modern digital devices measure several health parameters. Fitbit trackers use sensors such as accelerometers to tell how many steps we’ve taken in a day or how fast we’ve been walking. When can such novel health measures function as medical biomarkers?
The measures must be objective, quantifiable, and reproducible. Additionally, scientific evidence needs to show that the health attribute measured by the device maps consistently and accurately to a clinical outcome. For example, voice signals from a smartphone’s microphone can detect mild cognitive impairment due to Alzheimer’s disease. World War II, commanders and troops communicated using hand-sent Morse codes. To avoid capture by enemies, telegraph operators had to remain anonymous. Any clues about operator identity or location could influence battle outcomes.
New research published in Human Brain Mapping provides evidence of a shared neural mechanism that underlies sleep disturbance and mental disorders in preadolescents. The findings indicate that sleep disturbance and mental health problems are both related to the connectivity between and within two important brain networks.
“I noticed the importance of sleep years ago when I read several papers about the immediate amyloid protein deposition in the brain after short-term sleep deprivation. Amyloid is neurotoxic waste in the brain and needs to be transported out by cerebrospinal fluid,” said study author Ze Wang, an associate professor of diagnostic radiology and nuclear medicine at the University of Maryland School of Medicine.
“But cerebrospinal fluid is basically static most of the time. The best time to have more cerebrospinal fluid and increased flow rate is at night when you lay down and fall asleep. It is this time that our cerebral blood flow reduces. Because our brain has a fixed size, the reduction of cerebral blood flow creates space for cerebrospinal fluid and the inhomogeneous change of blood flow creates power for cerebrospinal fluid to flow and then transport the neural waste out. This is why our brain generates two times as much cerebrospinal fluid at night than daytime.”
We might be amidst a chip shortage, but if you enjoy reverse-engineering, there’s never a shortage of intriguing old chips to dig into – and the 2513N 5×7 character ROM is one such chip. Amidst a long thread probing a few of these (Twitter, ThreadReader link), [TubeTime] has realized that two address lines were shorted inside of the package. A Twitter dopamine-fueled quest for truth has led them to try their hand at making the chip work anyway. Trying to clear the short with an external PSU led to a bond wire popping instead, as evidenced by the ESD diode connection disappearing.
A dozen minutes of sandpaper work resulted in the bare die exposed, making quick work of the bond wires as a side effect. Apparently, having the bond pads a bit too close has resulted in a factory defect where two of the pads merged together. No wonder the PSU wouldn’t take that on! Some X-acto work later, the short was cleared. But without the bond wires, how would [TubeTime] connect to it? This is where the work pictured comes in. Soldering to the remains of the bond wires has proven to be fruitful, reviving the chip enough to continue investigating, even if, it appears, it was never functional to begin with. The thread continued on with comparing ROMs from a few different chips [TubeTime] had on hand and inferences on what could’ve happened that led to this IC going out in the wild.
Such soldering experiments are always fun to try and pull off! We rarely see soldering on such a small scale, as thankfully, it’s not always needed, but it’s a joy to witness when someone does IC or PCB microsurgery to fix factory defects that render our devices inoperable before they were even shipped. Each time that a fellow hacker dares to grind the IC epoxy layers down and save a game console or an unidentified complex board, the world gets a little brighter. And if you aren’t forced to do it for repair reasons, you can always try it in an attempt to build the smallest NES in existence!
𝙎𝙡𝙚𝙚𝙥 𝙢𝙖𝙮 𝙗𝙚 𝙤𝙣𝙚 𝙤𝙛 𝙩𝙝𝙚 𝙢𝙤𝙨𝙩 𝙥𝙤𝙩𝙚𝙣𝙩 𝙢𝙚𝙙𝙞𝙘𝙞𝙣𝙚𝙨 𝙛𝙤𝙧 𝙩𝙝𝙚 𝙗𝙧𝙖𝙞𝙣, 𝙨𝙘𝙞𝙚𝙣𝙩𝙞𝙨𝙩𝙨 𝙖𝙧𝙚 𝙙𝙞𝙨𝙘𝙤𝙫𝙚𝙧𝙞𝙣𝙜, 𝙖𝙨 𝙩𝙝𝙚𝙮 𝙚𝙭𝙥𝙡𝙤𝙧𝙚 𝙩𝙝𝙚 𝙞𝙣𝙣𝙚𝙧 𝙡𝙖𝙗𝙮𝙧𝙞𝙣𝙩𝙝𝙨 𝙤𝙛 𝙩𝙝𝙚 𝙩𝙝𝙧𝙚𝙚-𝙥𝙤𝙪𝙣𝙙 𝙤𝙧𝙜𝙖𝙣 𝙙𝙪𝙧𝙞𝙣𝙜 𝙙𝙚𝙚𝙥 𝙨𝙡𝙚𝙚𝙥 𝙖𝙣𝙙 𝙙𝙧𝙚𝙖𝙢 𝙘𝙮𝙘𝙡𝙚𝙨 𝙞𝙣 𝙗𝙤𝙩𝙝 𝙝𝙚𝙖𝙡𝙩𝙝 𝙖𝙣𝙙 𝙙𝙞𝙨𝙚𝙖𝙨𝙚.
The Neuro-Network.
𝐂𝐚𝐧 𝐝𝐞𝐞𝐩 𝐬𝐥𝐞𝐞𝐩 𝐡𝐞𝐥𝐩 𝐝𝐞𝐯𝐚𝐬𝐭𝐚𝐭𝐢𝐧𝐠 𝐛𝐫𝐚𝐢𝐧 𝐝𝐢𝐬𝐨𝐫𝐝𝐞𝐫𝐬? 𝐒𝐜𝐢𝐞𝐧𝐭𝐢𝐬𝐭𝐬 𝐬𝐭𝐮𝐝𝐲𝐢𝐧𝐠 𝐏𝐚𝐫𝐤𝐢𝐧𝐬𝐨𝐧’𝐬 𝐰𝐚𝐧𝐭 𝐭𝐨 𝐟𝐢𝐧𝐝 𝐨𝐮𝐭
𝙈𝙚𝙙𝙞𝙘𝙖𝙓𝙥𝙧𝙚𝙨𝙨:
Sleep may be one of the most potent medicines for the brain, scientists are discovering, as they explore the inner labyrinths of the three-pound organ during deep sleep and dream cycles in both health and disease.