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Category: neuroscience – Page 708

Recent therapeutic trials of “classical” psychedelic drugs, such as psilocybin (from magic mushrooms) or LSD, have reported benefits to wellbeing, depression and anxiety. These effects seem to be linked to a sense of “ego dissolution” — a dissolving of the subjective boundaries between the self and the wider world. However, the neurochemistry behind this effect has been unclear. Now a new paper, published in Neuropsychopharmacology, suggests that changes in brain levels of the neurotransmitter glutamate are key to understanding reports of ego dissolution — and perhaps the therapeutic effects of psychedelics.

Natasha Mason at Maastricht University, the Netherlands, and colleagues recruited 60 participants for their study. All had taken a psychedelic drug before, but not in the three months prior to the study. Half received a placebo and the other half were given a low to moderate dose of psilocybin (0.17 mg/kg of body weight).

The team then used a technique called proton magnetic resonance spectroscopy (MRS) to look at concentrations of glutamate (as well as other neurochemicals) in the medial prefrontal cortex (mPFC) and the hippocampus — two regions that have been implicated as key to the psychedelic drug experience. The team also looked at patterns of “functional connectivity” within networks of brain regions, a measure of how closely correlated brain activity is across those regions. Six hours after taking the drug or placebo, the participants reported on their subjective experiences using two surveys: The 5 Dimensions of Altered States of Consciousness and the Ego Dissolution Inventory.

As the researchers expected (based on the findings of earlier research), those given the drug reported increased feelings of ego dissolution, as well as altered states of consciousness. They also showed disruptions in the connectivity of particular networks, including the default mode network, which has also been implicated in past work on the effects of psychedelic drugs…

But, for the first time in humans, the team also observed higher levels of glutamate in the mPFC and lower levels in the hippocampus after taking psilocybin — and they linked these changes to different aspects of ego dissolution. Increases in the mPFC were most strongly linked to unpleasant aspects, such as a loss of control over thoughts and decision-making, and also anxiety. Decreases in the hippocampus, meanwhile, were most strongly linked to more positive aspects, such as feelings of unity with the wider world, and of having undergone a spiritual-type experience.

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She cooked up Italian food to protect her noodle!

A 60-year-old woman from the country’s Marche region prepared dozens of delicious stuffed olives while undergoing brain surgery — to reduce the risk of damaging the vital organ, according to a report Wednesday.

As doctors removed a brain tumor from her left temporal lobe, the unnamed patient whipped up 90 of the breaded-and-fried olives in a makeshift kitchen inside the operating room, according to the BBC.

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Speaking requires both sides of the brain. Each hemisphere takes over a part of the complex task of forming sounds, modulating the voice and monitoring what has been said. However, the distribution of tasks is different than has been thought up to now, as an interdisciplinary team of neuroscientists and phoneticians at Goethe University Frankfurt and the Leibniz-Centre General Linguistics Berlin has discovered: it is not just the right hemisphere that analyzes how we speak—the left hemisphere also plays a role.

Until now, it has been assumed that the spoken word arises in the left side of the brain and is analyzed by the right side. According to accepted doctrine, this means that when we learn to speak English and for example practice the sound equivalent to ‘th,’ the left side of the brain controls the motor function of the articulators like the tongue, while the right side analyzes whether the produced sound actually sounds as we intended.

The division of labor actually follows different principles, as Dr. Christian Kell from the Department of Neurology at Goethe University explains: “While the left side of the brain controls temporal aspects such as the transition between speech sounds, the right is responsible for the control of the sound spectrum. When you say ‘mother,’ for example, the left hemisphere primarily controls the dynamic transitions between ‘th’ and the vowels, while the right hemisphere primarily controls the sounds themselves.”

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Is it possible to rapidly increase (or decrease) the amount of information the brain can store?

A new international study led by the Research Institute of the McGill University Health Centre (RI-MUHC) suggests it may be. Their research has identified a molecule that improves brain function and memory recall is improved. Published in the latest issue of Cell Reports, the study has implications for neurodevelopmental and neurodegenerative diseases, such as autism spectrum disorders and Alzheimer’s disease.

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It has previously been discovered that tanycytes—cells found in part of the brain that controls —detect nutrients in and tell the brain directly about the food we have eaten.

Tanycytes do this by responding to found in foods, via the same receptors that sense the flavor of amino acids (“umami” taste), which are found in the taste buds of the tongue.

In the paper ‘Hypothalamic tanycytes generate acute hyperphagia through activation of the arcuate neuronal network.’ published today, the 8th June, in the journal PNAS, researchers from the School of Life Sciences at the University of Warwick, explain how tanycytes can increase appetite.

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