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First gene therapy for Tay-Sachs disease successfully given to two children

About 1 in 300 people in the general population carry the Tay-Sachs disease gene. Ray Kachatorian/Stone via Getty ImagesTwo babies have received the first-ever gene therapy for Tay-Sachs disease after over 14 years of development. Tay-Sachs is a severe neurological disease caused by a deficiency in an enzyme called HexA. This enzyme breaks down a fatlike substance that normally exists in very small, harmless amounts in the brain. Without HexA, however, this fatlike substance can accumulate to toxic levels that damage and kill neurons.

In the Process of Solving a Decades-Long Mystery, Scientists Discover Where Schizophrenia May Originate in the Brain

Researchers studying a protein that is strongly linked to the psychiatric disorder are the first to determine the protein’s function, tracing it to a structure in the hippocampus called the dentate gyrus.

In the process of solving a decades-long mystery about a particular protein, scientists have identified a specific location in the brain where schizophrenia may originate.

The news: Despite the identification of many genes that show some link to schizophrenia, identifying a part of the brain that is likely responsible for the disorder with a high level of certainty has proven to be extremely difficult — until now.

We Just Got Closer to Finding a Link Between Alzheimer’s And Circadian Rhythms

Long before Alzheimer’s disease is diagnosed, once-trusty proteins start to knot together in the brain in a process that may be hastened by poor sleep.

Now, scientists have uncovered a possible mechanism linking disruptions in circadian rhythms and the build-up of proteins associated with Alzheimer’s disease, by studying the rhythmic operation of immune cells and finding the molecular ‘timers’ that control them.

Circadian rhythms are the daily rhythms of bodily functions which are tied to our natural body clock, respond to light exposure, and govern our sleep-wake cycles.

Out of a total of 23 monkeys implanted with Elon Musk’s Neuralink brain chips at the University of California Davis between 2017 and 2020, at least 15 reportedly died

Via Business Insider and the New York Post, the news comes from the Physicians Committee for Responsible Medicine, an animal-rights group that viewed over 700 pages of documents, veterinary records, and necropsy reports through a public records request at the university.

-Wren Graves.

How Remote Workers Are Secretly Juggling Two Full-Time Jobs

Work remotely, work more jobs.


With the pandemic’s turbocharged acceleration of remote work options, many employees have sought to capitalize on the lack of personal supervision by secretly working two (or more) full-time jobs at once. But while there’s more money to be made, the strategy brings with it significant tradeoffs, namely mental health.

#Jobs #FutureofWork #BloombergQuicktake.

“The Future of Work” explores how work has changed during the Covid-19 pandemic, and which of these changes are likely here to stay — looking at office spaces, the shift in work culture, managers, & their employees from both a macro & micro level. Check out the rest of the series here: https://youtube.com/playlist?list=PLqq4LnWs3olXfYle__avndejcvzm-hDGA
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This bizarre looking helmet can create better brain scans

It may look like a bizarre bike helmet, or a piece of equipment found in Doc Brown’s lab in Back to the Future, yet this gadget made of plastic and copper wire is a technological breakthrough with the potential to revolutionize medical imaging. Despite its playful look, the device is actually a metamaterial, packing in a ton of physics, engineering, and mathematical know-how.

It was developed by Xin Zhang, a College of Engineering professor of mechanical engineering, and her team of scientists at BU’s Photonics Center. They’re experts in , a type of engineered structure created from small unit cells that might be unspectacular alone, but when grouped together in a precise way, get new superpowers not found in nature. Metamaterials, for instance, can bend, absorb, or manipulate waves—such as electromagnetic waves, , or radio waves. Each unit cell, also called a resonator, is typically arranged in a in rows and columns; they can be designed in different sizes and shapes, and placed at different orientations, depending on which waves they’re designed to influence.

Metamaterials can have many novel functions. Zhang, who is also a professor of electrical and computer engineering, , and and engineering, has designed an acoustic metamaterial that blocks sound without stopping airflow (imagine quieter jet engines and air conditioners) and a magnetic metamaterial that can improve the quality of magnetic resonance imaging (MRI) machines used for medical diagnosis.

Researchers introduce into human cells a genetic mutation that protects against Alzheimer’s disease

𝐌𝐞𝐝𝐢𝐜𝐚𝐥𝐗𝐩𝐫𝐞𝐬𝐬:

The Neuro-Network.

𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡𝐞𝐫𝐬 𝐢𝐧𝐭𝐫𝐨𝐝𝐮𝐜𝐞 𝐢𝐧𝐭𝐨 𝐡𝐮𝐦𝐚𝐧 𝐜𝐞𝐥𝐥𝐬 𝐚 𝐠𝐞𝐧𝐞𝐭𝐢𝐜 𝐦𝐮𝐭𝐚𝐭𝐢𝐨𝐧 𝐭𝐡𝐚𝐭 𝐩𝐫𝐨𝐭𝐞𝐜𝐭𝐬 𝐚𝐠𝐚𝐢𝐧𝐬𝐭 𝐀𝐥𝐳𝐡𝐞𝐢𝐦𝐞𝐫’𝐬 𝐝𝐢𝐬𝐞𝐚𝐬𝐞

𝙍𝙚𝙨𝙚𝙖𝙧𝙘𝙝𝙚𝙧𝙨 𝙛𝙧𝙤𝙢 𝙩𝙝𝙚 𝙐𝙣𝙞𝙫𝙚𝙧𝙨𝙞𝙩𝙚́ 𝙇𝙖𝙫𝙖𝙡 𝙁𝙖𝙘𝙪𝙡𝙩𝙮 𝙤𝙛 𝙈𝙚𝙙𝙞𝙘𝙞𝙣𝙚 𝙖… See more.


Researchers from the Université Laval Faculty of Medicine and CHU de Québec–Université Laval Research Center have successfully edited the genome of human cells grown in vitro to introduce a mutation providing protection against Alzheimer’s disease. The details of this breakthrough were recently published in The CRISPR Journal.

“Some increase the risk of developing Alzheimer’s disease, but there is a mutation that reduces this risk,” says lead author Professor Jacques-P. Tremblay. “This is a rare mutation identified in 2012 in the Icelandic population. The mutation has no known disadvantage for those who carry it and reduces the risk of developing Alzheimer’s disease. Using an improved version of the CRISPR gene editing tool, we have been able to edit the genome of human cells to insert this mutation.”

How Left and Right Hippocampal CA1 Regions in the Mouse Brain Talk With Each Other

Researchers have uncovered neural circuitry that allows the CA1 region of th… See more.


Summary: Researchers have uncovered neural circuitry that allows the CA1 region of the hippocampus to communicate with its counterpart in the opposite hemisphere despite there being no connection between them.

Source: RIKEN

RIKEN neuroscientists have uncovered the neural circuitry that permits a subregion in the hippocampus to communicate with its counterpart in the opposite hemisphere despite there being no direct connection between them. While not directly applicable to people, this finding is important for informing future studies of the mouse brain.

The hippocampus is well known for its role in learning and memory. Vertebrates have two hippocampi: one on the left side of the brain and the other on the right. Each hippocampus has various subregions, including the CA1 and CA3 areas.