Biodegradable devices that generate energy from the same effect behind most static electricity could help power transient electronic implants that dissolve in the body, researchers say.
However, when standard electronic implants run out of power, they need to be removed lest they eventually become sites of infection. But their surgical removal can result in potentially dangerous complications. Scientists are developing transient implantable electronics that dissolve once they are no longer needed, but these mostly rely on external sources of power, limiting their applications.
A study published in the journal Stem Cell Reports on March 23, led by Dr. Ryosuke Tsuchimochi and Professor Jun Takahashi, examined the effects of combining cell transplantation and gene therapy for axonal outgrowth in the central nervous system. The authors demonstrated the potential of this combinatorial therapy for promoting axonal regeneration in patients with central nervous system injuries.
Stroke and traumatic brain/spinal cord injuries often damage the corticospinal tract (CST), composed of descending axonal tracts from the motor cortex down the spinal cord, that innervates motor neurons to activate skeletal muscles for controlling voluntary movements. Pharmacological and surgical interventions, in conjunction with rehabilitation, can maintain some lost motor functions, but patients with such acute neural injuries often suffer from lifelong severe motor impairment.
Cell replacement therapy—the implantation of new neurons into damaged brain regions —is viewed as a last hope that could help patients recover sufficient motor functions to live a normal life. The research team previously demonstrated that brain tissues transplanted into injured mouse brains could find their way to the CST and spinal cord but believed that further optimization of the host environment was necessary to promote CST reconstruction and functional recovery.
Help us welcome Anders Sandberg to the Foresight family! As a Senior Research Fellow in Philosophy, we are proud that he will be joining a fantastic group of Foresight Senior Research Fellows: https://foresight.org/about-us/senior-research-fellows/
Anders will present a cherry-picked selection of his epic Grand Futures book project: What is available in the “nearer-term” for life if our immature civilization can make it past the tech/insight/coordination hurdles? We’ll focus on post-scarcity civilizations to get a sense of what is possible just past current human horizons in the hope it may inspire us to double down on solving humanity’s current challenges to unlock this next level.
Based on our Zoom polls, cognitive enhancement features as high interest for many of you and is also one of Anders’ main research interests. Let’s add a brief tour through different cognitive enhancement scenarios, their ethical considerations, and how to make progress in the right directions. Join us with your questions and comments and let’s give Anders a warm welcome into the Foresight community!
About Anders: Anders Sandberg is a Foresight Senior Fellow and a Research Associate at the Future of Humanity Institute from the University of Oxford. Anders Sandberg’s research at FHI centers on management of low-probability high-impact risks, estimating the capabilities of future technologies, and very long-range futures. Topics of particular interest include global catastrophic risk, cognitive biases, cognitive enhancement, collective intelligence, neuroethics, and public policy.
Anders is a Senior Research Fellow on the ERC UnPrEDICT Programme. He is a research associate to the Oxford Uehiro Centre for Practical Ethics, and the Oxford Centre for Neuroethics. He is on the advisory boards of a number of organizations and often debates science and ethics in international media.
A new publication released today in The EMBO Journal identified a key protein in the molecular mechanism triggering neurogenesis in the hippocampus. They found that tight regulation of Yap1 activity is essential as dysregulation can cause tissue disruption seen in the early stages of brain cancer.
Neurogenesis is the process by which new neurons are produced by neural stem cells (NSCs) in the brain. Neurogenesis is a crucial process in embryo development, but it also continues in some brain regions after birth and all throughout adulthood. In adulthood, neurogenesis is mainly responsible for brain plasticity.
In the adult hippocampus, a brain area responsible for memory and learning, most stem cells are held at quiescence. This reversible pause protects stem cells against damage and controls the rate of neurogenesis. When necessary, the stem cells can be taken off this pause to undergo activation. The mechanisms controlling quiescence and activation are still not fully understood.
Deep brain stimulation (DBS) is an experimental treatment strategy which uses an implanted device to help patients with severe depression who have reached a point where no other treatment works.
But despite her involvement in the DBS collaboration, which involves neuroscientists, neurosurgeons, electrophysiologists, engineers and computer scientists, neurologist Helen Mayberg does not see it as a long-term solution.
“I hope I live long enough to see that people won’t require a hole in their brain and a device implanted in this way,” she says. “I often have a nightmare with my tombstone that kind of reads like, what did she think she was doing?”
In a resort in Jamaica, athletes are finding solutions that Western medicine has missed.
A new report published Friday on ESPN
The mushrooms and therapy sessions are provided in Jamaica in the Good Hope Estate, a sugar plantation turned exclusive resort that claims to help those that prescription medication cannot.
Donald Hoffman interview on spacetime, consciousness, and how biological fitness conceals reality. We discuss Nima Arkani-Hamed’s Amplituhedron, decorated permutations, evolution, and the unlimited intelligence.
The Amplituhedron is a static, monolithic, geometric object with many dimensions. Its volume codes for amplitudes of particle interactions & its structure codes for locality and unitarity. Decorated permutations are the deepest core from which the Amplituhedron gets its structure. There are no dynamics, they are monoliths as in 2001: A Space Odyssey.
Background. 0:00 Highlights. 6:55 The specific limits of evolution by natural selection. 10:50 Don’s born in a San Antonio Army hospital in 1955 (and his parents’ background) 14:44 As a teenager big question he wanted answered, “Are we just machines?“ 17:23 Don’s early work as a vision researcher; visual systems construct. 20:43 Carlos’s 3-part series on Fitness-Beats-Truth Theorem.
Fitness-Beats-Truth Theorem. 22:29 Clarifications on FBT: Game theory simulations & math proofs. 24:20 What does he mean I can’t see reality? Fitness payoff functions don’t know about the truth… 28:23 Evolution shapes sensory systems to guide adaptive behavior… consider the virtual reality headset 32:45 FBT doesn’t include costs for extra bits of information processing 34:40 Joscha Bach’s “There are no colors in the universe”… though even light itself isn’t fundamental! 36:36 Map-territory relationship 40:27 Infinite regress, Godel’s Incompleteness Theorem 42:27 Erik Hoel’s causal emergence theory 45:40 Don’s take on causality: there are no causal powers within spacetime What’s Beyond Spacetime? 50:50 Nima Arkani-Hamed’s Amplituhedron 53:00 What percentage of physicists would agree spacetime is doomed? 56:00 Amplituhedron a static, monolithic, geometric object with many dimensions… 59:23 Ties to holographic principle, Ads-CFT correspondence 1:03:13 Quantum error correction 1:05:23 James Gates’ adinkra animations linking electromagnetism & electron-like objects The Unlimited Intelligence 1:08:30 Does Don still meditate 3 hours every day? 1:11:30 “We’re here for the ride…” 1:12:27 All my theories are trivial, there’s an unlimited intelligence that transcends 1:14:00 Carlos meanders on meditation 1:15:50 “You can’t know the truth, but you can be the truth” 1:17:43 Explore-Exploit Tradeoff (foraging strategy) 1:19:15 “You’re absolutely knocking on the right doors here”… our 4D spacetime for some reason essential for consciousness 1:21:10 Why this world, with these symbols, this interface? 1:22:20 “My guess, one of the cheaper headsets” Conscious Realism 1:24:40 Precise, mathematical model of consciousness… the end of Cantor’s infinities 1:28:30 Fusions of Consciousness paper… bridges between interactions of conscious agents/Markovian dynamics → decorated permutations → the Amplituhedron → spacetime 1:35:20 In a meta way, did Don choose the highest fitness path for his career? 1:39:10 “Don’t believe my theory, not the final word” 1:41:00 Where to find more of Don’s work 🚩Links to Donald Hoffman & More 🚩 “Do we see reality as it is?” (Ted Talk 2015) • Do we see reality…
“Symmetry Does Not Entail Veridicality” lecture (Hoffman 2017) • Don Hoffman — “Sy…
