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Summary: An estimated 13.6% of deaths in the U.S could be attributed to dementia. The number is 2.7 times higher than the official reported dementia-related deaths. The underestimation varies greatly by race, with 7.1 times more older Black adults, and 4.1 times more Hispanic adults, dying from dementia that public records indicate.

Source: boston university school of medicine.

Dementia may be an underlying cause of nearly three times more deaths in the U.S. than official records show, according to a new Boston University School of Public Health (BUSPH) study.

Summary: Discovery reveals neurons can lose their individuality in some conditions. The findings contradict the conventional belief that neurons always stay separated and never fuse.

Source: University of Queensland

A discovery that could rewrite the textbooks on neurons could also help us understand the basis of some neurological diseases.

Genetic variants may contribute to increased levels of antibodies against proteins of the Epstein-Barr virus — a known environmental risk factor for multiple sclerosis (MS) — in MS patients and their siblings, a study suggests.

The study, “EBNA-1 titer gradient in families with multiple sclerosis indicates a genetic contribution,” was published in the journal Neurology, Neuroimmunology and Neuroinflammation.

The belief or theory that the human race can evolve beyond its current physical and mental limitations,…

Elon Musk’s brain-machine interface company, Neuralink, has an event scheduled for later this week to update the public on its progress since last year’s presentation. While the agenda is speculative for the most part, one expectation is a live demonstration of neuron activity.

“Will show neurons firing in real-time on August 28th. The matrix in the matrix,” Musk tweeted at the end of July.

He also revealed a few other clues about the early fall announcement at the beginning of the year. “Wait until you see the next version vs what was presented last year. It’s *awesome*,” he wrote in February. “The profound impact of high bandwidth, high precision neural interfaces is underappreciated. Neuralink may have this in a human as soon as this year. Just needs to be unequivocally better than Utah Array, which is already in some humans & has severe drawbacks.”

Summary: Researchers explore the close relationship between depression and pain. For some people, unexplained symptoms of pain, such as back or headaches, could be an early indicator of depression before mood changes occur.

Source: Mayo Clinic

Pain and depression are closely related. Depression can cause pain – and pain can cause depression. Sometimes pain and depression create a vicious cycle in which pain worsens symptoms of depression, and then the resulting depression worsens feelings of pain.

Anacardic acid, a compound found in cashew nuts, promoted myelin regeneration and eased neuronal damage and disability in two mouse models of multiple sclerosis (MS).

These protective effects were associated with maturation of myelin-producing cells and production of IL-33, an immune-related molecule with a neuroreparative role in the central nervous system (CNS, the brain and spinal cord).

How we adapt to aging late in life may be genetically influenced, according to a study led by a psychologist at the University of California, Riverside.

The research, published in Aging Cell, has implications for how epigenetic factors relate to aging. Epigenesis is a process in which chemicals attached to DNA control its activity. Epigenetic changes, which can be passed on to offspring, may be critical to accelerated aging as well as declines in cognitive and physical functioning that often accompany aging. Epigenetic modifications resulting in altered gene expression may occur due to a number of biological processes, including one the researchers focused on: DNA methylation.

In DNA methylation, methyl groups are added to the DNA molecule. DNA has four different types of nucleotides: A, T, G, and C. DNA methylation occurs at the C bases of eukaryotic DNA. Changes in DNA methylation correlate strongly with aging.

Summary: Researchers identified a group of closely related genes that capture molecular links between Alzheimer’s and LATE, a common brain disorder that mimics Alzheimer’s symptoms.

Source: Brigham and Women’s Hospital

Alzheimer’s disease is one of the most common causes of dementia, and while most people might know someone who is affected by it, the genetic factors behind the disease are less known. A new study by investigators from Brigham and Women’s Hospital uncovered a group of closely related genes that may capture molecular links between Alzheimer’s disease and Limbic-predominant Age-related TDP-43 Encephalopathy, or LATE, a recently recognized common brain disorder that can mimic Alzheimer’s symptoms. LATE is often combined with Alzheimer’s disease to cause a more rapid cognitive decline. The study’s results are published in Neuron.