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What Does GABA Do in the Brain?

Despite the fact that sex is a basic instinct and a near-universal experience, we know remarkably little about it. And so, this week, we’re teaming up with our friends at Futurism, oracles of all things science, technology and medicine, to look at the past, present and future of pleasure from a completely scientific perspective.

For a while now, the neurotransmitter dopamine has been seen as the conductor of good feelings. It’s the subject of love songs, the seductress of biohackers and the ostensible “pleasure chemical.” But as research continues to uncover more about our brain’s reward system, dopamine is beginning to look less like the maestro and more like a member of the band.

Say Goodbye to Binge Eating: Signal Pathway in Brain That Controls Food Intake Discovered

A group of scientists has developed an entirely new approach to treating eating disorders.

They showed that a group of nerve cells (so-called AgRP, agouti-related peptide neurons) in the hypothalamus control the release of endogenous lysophospholipids, which in turn control the excitability of nerve cells in the cerebral cortex, which stimulates food intake.

In this process, the crucial step of the signaling pathway is controlled by autotaxin, an enzyme that is responsible for the production of lysophosphatidic acid.

Neuroscientists Built an Ultra Detailed Map of the Brain Motor Cortex, From Mice to Monkeys to Humans

Hundreds of neuroscientists built a ‘parts list’ of the motor cortex, laying groundwork to map the whole brain and better understand brain diseases.

Before you read any further, bring your hand to your forehead.

It probably didn’t feel like much, but that simple kind of motion required the concerted effort of millions of different neurons in several regions of your brain, followed by signals sent at 200 mph from your brain to your spinal cord and then to the muscles that contracted to move your arm.

Stanford Biochemists Successfully Change How the Brain Communicates With Itself

While you read this sentence, the neurons in your brain are communicating with one another by firing off quick electrical signals. They communicate with one another via synapses, which are tiny, specialized junctions.

There are many various kinds of synapses that develop between neurons, including “excitatory” and “inhibitory,” and scientists are still unsure of the specific methods by which these structures are formed. A biochemistry team has provided significant insight into this topic by demonstrating that the types of chemicals produced from synapses ultimately determine which types of synapses occur between neurons.

The impact of digital media on children’s intelligence while controlling for genetic differences in cognition and socioeconomic background

Video games seem to be a unique type of digital activity. Empirically, the cognitive benefits of video games have support from multiple observational and experimental studies23,24,25. Their benefits to intelligence and school performance make intuitive sense and are aligned with theories of active learning and the power of deliberate practice26,27. There is also a parallel line of evidence from the literature on cognitive training intervention apps28,29, which can be considered a special (lab developed) category of video games and seem to challenge some of the same cognitive processes. Though, like for other digital activities, there are contradictory findings for video games, some with no effects30,31 and negative effects32,33.

The contradictions among studies on screen time and cognition are likely due to limitations of cross-sectional designs, relatively small sample sizes, and, most critically, failures to control for genetic predispositions and socio-economic context10. Although studies account for some confounding effects, very few have accounted for socioeconomic status and none have accounted for genetic effects. This matters because intelligence, educational attainment, and other cognitive abilities are all highly heritable9,34. If these genetic predispositions are not accounted for, they will confound the potential impact of screen time on the intelligence of children. For example, children with a certain genetic background might be more prone to watch TV and, independently, have learning issues. Their genetic background might also modify the impact over time of watching TV. Genetic differences are a major confounder in many psychological and social phenomena35,36, but until recently this has been hard to account for because single genetic variants have very small effects. Socioeconomic status (SES) could also be a strong moderator of screen time in children37. For example, children in lower SES might be in a less functional home environment that makes them more prone to watch TV as an escape strategy, and, independently, the less functional home environment creates learning issues. Although SES is commonly assumed to represent a purely environmental factor, half of the effect of SES on educational achievement is probably genetically mediated38,39—which emphasizes the need for genetically informed studies on screen time.

Here, we estimated the impact of different types of screen time on the change in the intelligence of children in a large, longitudinal sample, while accounting for the critical confounding influences of genetic and socioeconomic backgrounds. In specific, we had a strong expectation that time spent playing video games would have a positive effect on intelligence, and were interested in contrasting it against other screen time types. Our sample came from the ABCD study (http://abcdstudy.org) and consisted of 9,855 participants aged 9–10 years old at baseline and 5,169 of these followed up two years later.

Antidepressant-like effects of transcorneal electrical stimulation in rat models

Given that visual impairment is bi-directionally associated with depression, we examined whether transcorneal electrical stimulation (TES), a non-invasive treatment for visual disorders, can ameliorate depressive symptoms.

The putative antidepressant-like effects of TES and the underlying mechanisms were investigated in an S334ter-line-3 rat model of retinal degeneration and a rat model of chronic unpredictable stress (CUS).

TES was administered daily for 1 week in S334ter-line-3 and CUS rats. The effects of TES on behavioral parameters, plasma corticosterone levels, and different aspects of neuroplasticity, including neurogenesis, synaptic plasticity, and apoptosis, were examined.

Can minds persist when they are cut off from the world?

Could a brain ever exist on its own, divorced from or independent of a body? For a long time, philosophers have pondered such “brain-in-a-vat” scenarios, asking whether isolated brains could maintain consciousness when separated from their bodies and senses. Typically, a person’s experiences are characterized by a web of interactions between the human brain, body and environment. But recent developments in neuroscience mean this conversation has moved from the realm of hypothetical speculation and science fiction, to isolated examples where consciousness could be sealed off from the rest of the world.


It may sound like science fiction, but can actual science keep a brain alive in a vat?