Wyler, S.C. et al. identify a critical neuronal population that is required for GPR75 to exert its obesogenic effects using targeted deletion and reactivation of Gpr75 in glutamatergic neurons.
Category: neuroscience – Page 54
Clarifying the conceptual dimensions of representation in neuroscience
Appeals to representation are widespread, despite neuroscientists’ uncertainty about what kind of findings count as evidence for such claims. In this Perspective, Pohl and colleagues develop a unified framework that distinguishes four conceptual dimensions relevant to representation, illustrating them in information-theoretic terms to explicitly characterize representation in neuroscience.
Potential Risks of Blocking GDF15‐Based Brain Energy Sensing
GDF15 signals energetic stress to the brain, leading to unpleasant symptoms as the body conserves and reallocates energy. In conditions such as frailty and cancer, suppression of GDF15 signaling is expected to lead to an improvement in symptoms, but potentially at the cost of long-term health and survival.
Working memory may rely on calcium-tuned synaptic boosts, study suggests
Working memory is a cognitive function that is essential for carrying out everyday activities and temporarily retaining information. This process enables us to understand information, learn and manage responses in a controlled manner—abilities that are often impaired in certain neurodegenerative diseases. Now, a study published in Cell Reports has identified a molecular pathway in the brain that is crucial for the proper functioning of working memory.
The study, conducted using animal models, is led by Francisco José López-Murcia, a professor at the Faculty of Medicine and Health Sciences and the Institute of Neurosciences of the University of Barcelona (UBneuro), and a member of the Bellvitge Biomedical Research Institute (IDIBELL). The team led by Professor Nils Brose at the Max Planck Institute for Multidisciplinary Sciences (MPI-NAT, Göttingen, Germany) is also participating in the project.
In utero exposure to NMDA receptor autoantibodies disrupts hippocampal circuit maturation
Majoros, Zhang, and Rahmati et al. identify a link between maternal autoimmunity and disrupted neuronal network development in the hippocampus of mice. In utero exposure to NMDA receptor autoantibodies impairs GABAergic signaling and early network synchrony in neonates, hindering the emergence of continuous hippocampal activity around eye opening.
Blood-brain barrier disruption, traumatic encephalopathy, and cognitive decline in retired athletes
Traumatic head injuries from collision and combat sports disrupt the blood-brain barrier and trigger inflammation for years after retirement, shows a new MRI and transcriptomic analysis of retired athletes.
Find out more in Science TranslationalMedicine.
Sci. Transl. Med. 18, eadu6037 (2026). DOI:10.1126/scitranslmed.adu6037
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