Lifeboat Foundation

Rune Labs, a precision neurology company, has announced its StrivePD software ecosystem for Parkinson’s disease has been granted 510(k) clearance by the US Food and Drug Administration (FDA) to collect patient symptom data through measurements made by Apple Watch.

By combining powerful wearable technology and self-reported symptom information with brain imaging, electrophysiology, genetic and other clinical data, StrivePD enables a data-driven approach to care management and clinical trial design for Parkinson’s.

Longevity. Technology: With this clearance, the Rune Labs’ StrivePD app enables precision clinical care and trial participation for tens of thousands of Parkinson’s patients who already use these devices in their daily lives.

Summary: Using single-cell technology, researchers discover how the social division of labor in an ant colony reflects in the functional specialization of the ant brain at a cellular level.

Source: BGI Group.

International researchers led by China’s BGI-Research used single cell technology to study the brains of ants, explaining for the first time how the social division of labor within ant colonies reflects in the functional specialization of their brains at cellular levels.

Enjoy the talk given by Liz Parrish on June 14, 2022 during the Digital Enterprise Show 2022. The event took place from June 14th to the 16th in Málaga, Spain.

BioViva Science is using bioinformatics to improve gene therapies to enhance healthy human longevity and combat age-related diseases like Alzheimer’s, diabetes, cancer, and heart disease. TimeKeeper™ is an epigenetic clock and the BioViva BioVault™ is a bioinformatics database for researchers and consumers.

Understanding the mind and how thinking occurs has been a challenge for philosophers, scientists, theorists, educators, and artists throughout history. Until recently, ideas about how we learn have been mainly theoretical and intuitive. However, with ongoing advances in neuroscience, considerable progress is occurring. As a result, a paradigm shift is taking hold in human cognition, pointing to a new science-based understanding about the way we think and, ultimately, the way we learn.

This paradigm shift — a move away from traditional notions of the mind to an “embodied cognition” model of human thinking and learning — is the subject of a new book “Movement Matters: How Embodied Cognition Informs Teaching and Learning”. The book is summarised as follows:

Continue reading “Embodied cognition and the future of teaching and learning” »

Scientists have created the first reference charts for the human brain, mapping its growth from infancy to 100 years old. Now, they have to grapple with difficult ethical questions about how they should — and perhaps shouldn’t — be used.

The reference charts are visualizations created from aggregating analyses of over 120,000 brain scans to show ranges in brain size, or gray matter volume, for each age. They also track the human brain’s rapid expansion early in life and its gradual shrinking over time. The researchers primarily developed the charts to provide a standardized measurement that other neuroscientists could use for brain imaging research, with the hope that maybe one day it could lead to a tool used in clinics.

“It’s an absolutely spectacular advancement in neuroscience and neuroimaging,” said Judy Illes, professor of neurology and neuroethics at the University of British Columbia.

Circa 2020

Gene therapy shows promise for clinical benefit in demyelinating, neurodegenerative disease.

Krabbe disease is an aggressive, incurable pediatric neurodegenerative disease caused by mutations in the galactosylceramidase (GALC) gene. Deficiency of the GALC protein activity leads to cytotoxic accumulation of a cellular metabolite called psychosine, which compromises normal turnover of myelin in the central and peripheral nervous system (CNS, PNS). The ensuing damage leads to progressive disease, including paralysis, loss of sensory functions and death, in the developing infant. The incidence of Krabbe disease is estimated at 1 in 100,000 live births.

Continue reading “Krabbe Disease Successfully Treated With Gene Therapy in Preclinical Animal Model” »

With 17.3 million adult Americans affected, depression is one of the most prevalent mental disorders in the country. A gloomy or depressed mood that lasts for two weeks or more is considered major depression.

Depression is distinct from common mood swings and brief emotional reactions to problems in daily life. Depression may develop into a serious medical condition, particularly if it is recurring and of moderate to severe intensity. The afflicted individual may experience severe suffering and perform badly at work, in school, and with family. In the worst cases, depression might result in suicide.

Since its introduction in the late 1980s to prevent heart attack and stroke, statins have been hailed as a wonder drug and prescribed to tens of millions of individuals. However, some research has suggested that the medications may still have other benefits, particularly those for mental health. A recent study investigates the impact of statins on the emotional bias, a risk factor for depression. The study appears in Biological Psychiatry and was published by Elsevier.

Summary: A new, open-source model of synaptic plasticity in the neocortex could propel understanding of how learning occurs in the brain.

Source: University of Montreal.

Everyone knows the human brain is extremely complex—but how does it learn, exactly? Well, the answer may be a lot simpler than commonly believed.