Researchers developed seven MRI-based biological age clocks across major organs using UK Biobank imaging, linking each to proteins, metabolites, genetics, disease risks, mortality, and cognitive decline. These organ-specific age gaps reveal how uneven aging shapes vulnerability to conditions such as diabetes, hypertension, and dementia, opening new paths for precision prevention and clinical trial stratification
Because of the “all-or-none” character of nervous activity, neural events and the relations among them can be treated by means of propositional logic. It is found that the behavior of every net can be described in these terms, with the addition of more complicated logical means for nets containing circles; and that for any logical expression satisfying certain conditions, one can find a net behaving in the fashion it describes. It is shown that many particular choices among possible neurophysiological assumptions are equivalent, in the sense that for every net behaving under one assumption, there exists another net which behaves under the other and gives the same results, although perhaps not in the same time. Various applications of the calculus are discussed.
Babies born too soon seem to have stronger connections in one of the major brain areas that supports language processing if they regularly heard their mother read them a story while in intensive care
The gang catches up with Emil Kendziorra after the Biostasis 2025 conference at the European Biostasis Foundation. Watch it on YouTube here. Topics covered include:
• How to get a Tomorrow Bio ambulance in your hometown.
• Tomorrow Bio’s plan to collect brain samples to check ultra-structure preservation in its cryonics patients — and how it will respond to what it finds.
• What’s new and what’s next for Tomorrow Bio.
• Our near death experiences.
Links:
• Cryosphere Discord Server: / discord.
• Cryonics Subreddit: / cryonics.
As Parkinson’s disease progresses, harmful protein clumps build up in the brain, blocking communications between neurons and killing them off – but what if we could prevent these clusters from forming?
Researchers led by a team from the University of Bath in the UK have achieved just that in a basic worm model of Parkinson’s. They engineered a peptide, a small amino acid chain, to essentially keep a protein called alpha-synuclein locked in its healthy shape. This prevented the misfolding that leads to clumps.
The potential treatment checks several important boxes: it’s durable, and it can survive inside cells without causing any toxic side effects.
What if the universe is a machine, and every moment in our past, present, and future is already encoded in the positions of its particles?
Physicist Sean Carroll explores the unsettling implications of classical mechanics, from Newton’s laws to Laplace’s thought experiment, showing how determinism challenges the very idea of free will.