Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: neuroscience – Page 401

Have you ever made a great catch—like saving a phone from dropping into a toilet or catching an indoor cat from running outside? Those skills—the ability to grab a moving object—takes precise interactions within and between our visual and motor systems. Researchers at the Del Monte Institute for Neuroscience at the University of Rochester have found that the ability to visually predict movement may be an important part of the ability to make a great catch—or grab a moving object.

“We were able to develop a method that allowed us to analyze behaviors in a natural environment with high precision, which is important because, as we showed, differ in a controlled setting,” said Kuan Hong Wang, Ph.D., a Dean’s Professor of Neuroscience at the University of Rochester Medical Center.

Wang led the study out today in Current Biology in collaboration with Jude Mitchell, Ph.D., assistant professor of Brain and Cognitive Sciences at the University of Rochester, and Luke Shaw, a graduate student in the Neuroscience Graduate Program at the School of Medicine & Dentistry at the University of Rochester. “Understanding how natural behaviors work will give us better insight into what is going awry in an array of neurological disorders.”

Read more | >

BOCA RATON, Fla. (AP) — Before Fred Kalfon began exercising at the Grey Team veterans center a couple months ago, the 81-year-old rarely left his Florida home.

Parkinson’s disease, an inner ear disorder and other neurological problems, all likely caused by the Vietnam vet’s exposure to the infamous defoliant Agent Orange, made it difficult for him to move. His post-traumatic stress disorder, centering on the execution of a woman who helped his platoon, was at its worst.

Read more | >

Switching to a diet full of fresh veggies and low in processed foods could do wonders for your brain’s biological age, new research shows.

According to the international team of researchers who ran the study, eating a Mediterranean diet rich in vegetables, seafood, and whole grains appears to slow the signs of accelerated brain aging typically seen in obesity with as little as 1 percent loss in body weight.

Brain scans taken after 18 months showed the participants’ brain age appearing almost 9 months younger than expected, compared to estimates of their brain’s chronological age.

Read more | >

The ability of the phenomenon of criticality to explain the sudden emergence of new properties in complex systems has fascinated scientists in recent decades. When systems are balanced at their “critical point,” small changes in individual units can trigger outsized events, just as falling pebbles can start an avalanche. That abrupt shift in behavior describes the phase changes of water from ice to liquid to gas, but it’s also relevant to many other situations, from flocks of starlings on the wing to stock market crashes. In the 1990s, the physicist Per Bak and other scientists suggested that the brain might be operating near its own critical point. Ever since then, neuroscientists have been searching for evidence of fractal patterns and power laws at work in the brain’s networks of neurons. What was once a fringe theory has begun to attract more mainstream attention, with researchers now hunting for mechanisms capable of tuning brains toward criticality.

Learn more about the critical brain hypothesis: https://www.quantamagazine.org/a-physical-theory-for-when-th…-20230131/

- VISIT our Website: https://www.quantamagazine.org.
- LIKE us on Facebook: https://www.facebook.com/QuantaNews.
- FOLLOW us Twitter: https://twitter.com/QuantaMagazine.

Quanta Magazine is an editorially independent publication supported by the Simons Foundation https://www.simonsfoundation.org/

Read more | >

Northwestern Medicine investigators have developed a novel nanoparticle treatment for glioblastoma, according to a study published in Nature Communications.

Glioblastoma, the most common type of primary brain cancer, is one of the most complex, deadly and treatment-resistant cancers, according to the National Brain Tumor Society. The five-year survival rate for patients hovers near 7% and has remained unchanged for decades.

Previous Northwestern Medicine research has shown that glioblastoma tumors accumulate large numbers of immunosuppressive tumor-associated (TAMCs), which impairs the immune system’s ability to fight the tumor and reduces the effectiveness of radiation and chemotherapy.

Read more | >

Why does all of this matter? The unfortunate truth is that each of us will experience plenty of mental pain, misery, and frustration in our lifetimes. Mistaking the voice in our head for a thing and labeling it “me” brings us into conflict with the neuropsychological evidence that shows there is no such thing. This mistake — this illusory sense of self — is the primary cause of our mental suffering. When you can’t sleep at night, is it because you are worried about a stranger’s problems, or is it your problems that keep you up? For most of us, we worry about my work problems, my money problems, and my relationship problems. What would happen if we removed the “self” from these problems?

I am distinguishing mental suffering from physical pain. Pain occurs in the body and is a physical reaction—like when you stub your toe or break an arm. The suffering I speak of occurs in the mind only and describes things such as worry, anger, anxiety, regret, jealousy, shame, and a host of other negative mental states. I know it’s a big claim to say that all these kinds of suffering are the result of a fictitious sense of self. For now, the essence of this idea is captured brilliantly by Taoist philosopher and author Wei Wu Wei when he writes, “Why are you unhappy? Because 99.9 percent of everything you think, and of everything you do, is for yourself — and there isn’t one.”

Read more | >

Multiple sclerosis (MS) affects roughly 2.5 million people worldwide and is a neurological disease affecting the brain and spinal cord. More specifically, MS is when the immune system attacks the body’s protective layer around nerve fibers known as myelin sheaths. The breakdown of myelin sheath leads to a disconnect between your brain and body. The immune cells responsible for myelin sheath deterioration include CD4+ T cells, or effector cells, which are part of the body’s first line of defense. In MS, the effector cells do not recognize that the myelin sheath is a normal part of the body. Therefore, the effector cells become the dominant cell type, trying to kill and get rid of the myelin sheath. The immune response will generate inflammation which destroys the myelin sheath leading to a disruption of signals along the nerves from the brain to the body.

A group of researchers at Johns Hopkins University School of Medicine recently published a therapy that controls the symptoms of MS. The goal of the therapy was to stop effector cells from attacking the myelin sheath and to promote the production of T regulatory cells-or T regs-which have been demonstrated to reduce autoimmune effects.

Dr. Giorgio Raimondi, PhD, MSc, Jordan Green, and others used three therapeutic agents to control MS symptoms. Researchers used microparticles, which are small, bioengineered spheres to deliver the agents. The first agent is a combination of two proteins which include Interleukin-2 (IL2) and an antibody that promotes T reg production. IL2 stimulates T cell expansion, while the antibody blocks specific parts of IL2 to specifically expand T regs compared to effector cells. The second agent includes a molecule that presents a protein specific to myelin so that the immune response will generate T regs specifically designed to protect the myelin sheath. Finally, the third agent is rapamycin, which is an immunosuppressant drug designed to reduce effector T cells.

Read more | >

We’ve been waxing lyrical (and critical) about Apple’s Vision Pro here at TechCrunch this week – but, of course, there are other things happening in the world of wearable tech, as well. Sol Reader raised a $5 million seed round with a headset that doesn’t promise to do more. In fact, it is trying to do just the opposite: Focus your attention on just the book at hand. Or book on the face, as it were.

“I’m excited to see Apple’s demonstration of the future of general AR/VR for the masses. However, even if it’s eventually affordable and in a much smaller form factor, we’re still left with the haunting question: Do I really need more time with my smart devices,” said Ben Chelf, CEO at Sol. “At Sol, we’re less concerned with spatial computing or augmented and virtual realities and more interested in how our personal devices can encourage us to spend our time wisely. We are building the Sol Reader specifically for a single important use case — reading. And while Big Tech surely will improve specs and reduce cost over time, we can now provide a time-well-spent option at 10% of the cost of Apple’s Vision.”

The device is simple: It slips over your eyes like a pair of glasses and blocks all distractions while reading. Even as I’m typing that, I’m sensing some sadness: I have wanted this product to exist for many years – I was basically raised by books, and lost my ability to focus on reading over the past few years. Something broke in me during the pandemic – I was checking my phone every 10 seconds to see what Trump had done now and how close we were to a COVID-19-powered abyss. Suffice it to say, my mental health wasn’t at its finest – and I can’t praise the idea of Sol Reader enough. The idea of being able to set a timer and put a book on my face is extremely attractive to me.

Read more | >

Worth a listen to understand the current reality and the future potential:

Go to https://ground.news/sabine to stay fully informed on breaking news, compare coverage and avoid media bias. Subscribe using my link to get 30% off the Vantage plan for unlimited access.

Technological enhancements and implants are becoming more popular amongst a group of transhumanists who call themselves “grinders”. Are we coming closer to an age of cyborgs? Is genetic screening and editing ethical? Has biohacking lost all meaning? What are nootropics? That’s what we’ll talk about today.

💌 Support us on Donatebox ➜ https://donorbox.org/swtg.
👉 Transcript with links to references on Patreon ➜ https://www.patreon.com/Sabine.
📩 Sign up for my weekly science newsletter. It’s free! ➜ https://sabinehossenfelder.com/newsletter/
🔗 Join this channel to get access to perks ➜
https://www.youtube.com/channel/UC1yNl2E66ZzKApQdRuTQ4tw/join.
🖼️ On instagram ➜ https://www.instagram.com/sciencewtg/

The four examples from the introduction are here:

Continue reading “Should we take evolution into our own hands and become transhuman?” | >