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The consistency and vulnerability of the brain is demonstrated along with the clear and glistening pia and arachnoid and the tough dura. The cushioning function of the CSF is stressed and the features are pointed out on the ventral surface. The uncus and temporal lobes are normal with arteries free of atherosclerosis.

This is 2 of a series of 26 videos to be viewed in the suggested order or intermixed with other curricular materials. The entire series can be accessed here:
https://neurologicexam.med.utah.edu/adult/html/brain-dissections.html.

The videos may be downloaded in various formats by going here:
https://neurologicexam.med.utah.edu/adult/html/download_instructions.html.

Password Request form for downloadable Neuroanatomy Brain Dissection videos here: https://library.med.utah.edu/neuro-exam/

The motor cortex controls the voluntary movement of muscles. It remains largely unclear why its electrical or magnetic stimulation can alleviate therapy-resistant chronic pain—albeit unreliably. An interdisciplinary research group at the Medical Faculty of Heidelberg (MFHD) has now tracked down the underlying mechanisms and nerve pathways in mice.

The scientists showed that certain nerve pathways of the motor cerebral cortex are indirectly connected to the emotion centers in the brain, process both -related information and emotions by direct activation, and thus reduce the sensation of pain. Consequently, the team not only defines a new brain circuit for neurostimulation in pain therapy, but also brings the brain’s own reward system into focus as a starting point for future treatments. The results are now published in the journal Science.

The research was conducted within the framework of CRC1158 “From Nociception to Chronic Pain,” whose spokesperson is Professor Dr. Rohini Kuner, Director of the Institute of Pharmacology at the MFHD.

Mini brains grown in a lab from stem cells spontaneously developed rudimentary eye structures, scientists reported in a fascinating 2021 paper.

On tiny, human-derived brain organoids grown in dishes, two bilaterally symmetrical optic cups were seen to grow, mirroring the development of eye structures in human embryos. This incredible result could help us to better understand the process of eye differentiation and development, as well as eye diseases.

“Our work highlights the remarkable ability of brain organoids to generate primitive sensory structures that are light sensitive and harbor cell types similar to those found in the body,” said neuroscientist Jay Gopalakrishnan of University Hospital Düsseldorf in Germany in a 2021 statement.

We may have evolved to be “naive realists,” guided by a deep subconscious intuition that we perceive the world as it truly is. In practice, perhaps, our reality could be described as “augmented” with our assumptions about the world. These assumptions are acquired through our limited means of learning, distorted by cognitive and motivational biases. We shouldn’t be too harsh on our brains, though. Just imagine what it must be like for them – confined to Plato’s cave of the skull, tasked with assembling an accurate picture of the outside world from a barrage of noisy electrical signals.

We often mistakenly assume that every child’s mind is a blank slate before they start formal learning. However, current research suggests that we begin to rely on underlying assumptions about the world quickly after we are born. Infants already have basic physical expectations and are surprised when the behavior of objects contradicts them. Implicit assumptions about the world, which develop during infancy and continue into adulthood, direct our basic perceptual and motor activities. You may have experienced them when picking up a milk carton you didn’t know was empty: your hand unexpectedly flew up as your brain overestimated the amount of effort required to lift the carton. Our inability to “unsee” an optical illusion – even after observing it multiple times and clearly understanding its mechanics – also suggests the resiliency of our expectations.

If our beliefs are so unreliable, why do we place so much confidence in them? As it turns out, the feeling of certainty in our convictions is merely a physical sensation akin to hunger. This feeling may have evolved as a “circuit breaker” to help our ancient ancestors with instant life-and-death decisions. Any uncertainty could delay immediate action and spell disaster. As a result, we appear wired to experience discomfort in the face of uncertainty. Our intuition may suggest that our confidence must grow as we gain skills. Yet, in practice, the more we learn, the more we realize how much there is to know. The famous Dunning-Kruger chart illustrates how we start out overconfident in our understanding and then become more humble as our expertise increases. Since we are likely to be unaware of our hubris, we need to learn strategies to avoid overconfidence and identify our misconceptions. As always, it is best to start early.

Mental health has become a widespread topic nowadays.

In the past, discussions concerning mental health were often hushed up or altogether swept under the rug. A gradual cultural change has led to openly considering mental health issues and eased qualms about doing so in publicly acknowledged ways.

You might give some of the credit for this change in overarching societal attitudes as an outcome of the advent of easily accessed smartphone apps that aid your personal mindfulness and presumably spur you toward mental well-being. There are apps for mindfulness, ones for meditation, ones for diagnosing your mental health status, ones for doing mental health screening, and so on.


People on social media are touting the use of generative AI such as ChatGPT as handy for interactively providing mental health advice. This is a worrisome trend. AI Ethics and AI Law are stressed out and cautioning that this is not a sound idea.

𝐒𝐭𝐚𝐧𝐟𝐨𝐫𝐝 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡𝐞𝐫𝐬 𝐭𝐡𝐢𝐧𝐤 𝐚 𝐰𝐢𝐫𝐞𝐥𝐞𝐬𝐬 𝐛𝐫𝐚𝐢𝐧 𝐢𝐦𝐩𝐥𝐚𝐧𝐭 𝐜𝐨𝐮𝐥𝐝 𝐫𝐞𝐦𝐨𝐯𝐞 𝐭𝐮𝐦𝐨𝐫𝐬

𝙍𝙚𝙨𝙚𝙖𝙧𝙘𝙝𝙚𝙧𝙨 𝙖𝙩 𝙎𝙩𝙖𝙣𝙛𝙤𝙧𝙙 𝙈𝙚𝙙𝙞𝙘𝙞𝙣𝙚 𝙝𝙖𝙫𝙚 𝙙𝙚𝙫𝙚𝙡𝙤𝙥𝙚𝙙 𝙖 𝙨𝙢𝙖𝙡𝙡 𝙬𝙞𝙧𝙚𝙡𝙚𝙨𝙨 𝙙𝙚𝙫𝙞𝙘𝙚 𝙩𝙝𝙖𝙩 𝙘𝙤𝙪𝙡𝙙 𝙬𝙞𝙧𝙚𝙡𝙚𝙨𝙨𝙡𝙮 𝙧𝙚𝙢𝙤𝙫𝙚 𝙙𝙚𝙖𝙙𝙡𝙮 𝙗𝙧𝙖𝙞𝙣 𝙩𝙪𝙢𝙤𝙧𝙨.


Researchers think a wireless implant to treat brain tumors could eliminate hospital visits for cancer treatment. [Image courtesy of Stanford Medicine]

According to the researchers, brain tumors are some of the most deadly and difficult-to-treat cancers. Glioblastoma, an aggressive form of brain tumor, kills more than 10,000 Americans a year.

To learn to socialize, zebrafish need to trust their gut.

Gut microbes encourage specialized cells to prune back extra connections in brain circuits that control social behavior, new University of Oregon research in zebrafish shows. The pruning is essential for the development of normal social behavior.

The researchers also found that these ‘social’ neurons are similar in zebrafish and mice. That suggests the findings might translate between species — and could possibly point the way to treatments for a range of neurodevelopmental conditions.

Summary: By inhibiting NMDA receptors, ketamine increases noise to gamma frequencies in one layer of the thalamic nucleus and one lay of the somatosensory cortex. Findings suggest psychosis may be triggered by an increase in background noise impairing thalamocortical neurons which may be caused by a malfunction in NMDA receptors affecting the balance of inhibition and excitation in the brain.

Source: HSE

An international team of researchers including Sofya Kulikova, Senior Research Fellow at the HSE University-Perm, found that ketamine, being an NMDA receptor inhibitor, increases the brain’s background noise, causing higher entropy of incoming sensory signals and disrupting their transmission between the thalamus and the cortex.