Menu

Blog

Archive for the ‘neuroscience’ category: Page 336

Aug 15, 2022

Neuroscience research suggests LSD might enhance learning and memory

Posted by in categories: biotech/medical, neuroscience

New research published in Experimental Neurology provides some initial evidence that the psychedelic substance known as LSD has nootropic properties. The study found that LSD increased markers of neuroplasticity in human brain organoids, increased novelty preference in rats, and improved memory performance in humans.

When combined with psychotherapy, psychedelic drugs have shown promise in the treatment of psychiatric conditions such as depression, PTSD, and addiction. But the cellular and molecular mechanisms involved in the therapeutic effects of psychedelics remains unclear.

Some research has indicated that psychedelic substances produce positive impacts, in part, because they promote neurogenesis and neuroplasticity. The authors of the new study were interested in better understanding whether the neuroplasticity induced by psychedelics could be harnessed to enhance learning and memory.

Aug 15, 2022

Donald Hoffman Λ Joscha Bach on Consciousness, Free Will, and Gödel [Theolocution]

Posted by in categories: computing, education, information science, neuroscience

Deep dive into the nature of consciousness and reality.

Sponsors: https://brilliant.org/TOE for 20% off. For Algo’s podcast https://www.youtube.com/channel/UC9IfRw1QaTglRoX0sN11AQQ and website https://www.algo.com/.

Continue reading “Donald Hoffman Λ Joscha Bach on Consciousness, Free Will, and Gödel [Theolocution]” »

Aug 15, 2022

Researchers discover new molecules with longevity boosting potential

Posted by in categories: biotech/medical, life extension, neuroscience

Researchers at the Hebrew University of Jerusalem have discovered a new family of molecules that enable cells to repair damaged components, making it possible for those tissues to retain proper function. The efficacy of the molecules was demonstrated on a model organism – the C. elegans roundworm. The research team examined the effect of various therapies on longevity and quality of life, and successfully showed they can protect the worm and human cells from damage.

The researchers, led by Professors Einav Gross and Shmuel Ben-Sasson, have founded a company called Vitalunga to advance the research and translate it into therapeutics.

Longevity. Technology: A major factor in aging tissues is the reduced effectiveness of our cell’s quality-control mechanism, which leads to the accumulation of defective mitochondria – the cellular ‘power plants’ responsible for energy production. Mitochondria can be compared to tiny electric batteries that help cells function properly. Although these ‘batteries’ wear out constantly, our cells have a sophisticated mechanism called mitophagy that removes defective mitochondria and replaces them with new ones. However, this mechanism declines with age, leading to cell dysfunction and deterioration in tissue activity, and is implicated in many age-related diseases, such as Alzheimer’s disease, Parkinson’s disease, heart failure and sarcopenia.

Aug 15, 2022

New Alzheimer’s Drug Avoids Inflammatory Side Effects

Posted by in categories: biotech/medical, neuroscience

Aug 15, 2022

Want to protect your brain from aging? Learn another language

Posted by in categories: biotech/medical, life extension, neuroscience

Being bilingual slows down the negative effects of aging on the brain.

Our brains start slowing down in their once-magical abilities after a certain age.

Scientists have been finding out is that there are methods that can slow down the aging of the brain.

Continue reading “Want to protect your brain from aging? Learn another language” »

Aug 15, 2022

Physicist Claims To Have Solved the Mystery of Consciousness

Posted by in category: neuroscience

According to the theory, all that’s needed to solve the hard problem of consciousness is to change our assumptions about it. When we realize that consciousness is a physical, relativistic phenomenon, the mystery of consciousness naturally dissolves.

How do 3 pounds of brain tissue create thoughts, feelings, mental images, and a detailed inner world?

The ability of the brain to create consciousness has baffled people for millennia. The mystery of consciousness lies in the fact that each of us has subjectivity, with the ability to sense, feel, and think. In contrast to being under anesthesia or in a dreamless deep sleep, while we’re awake we don’t “live in the dark” — we experience the world and ourselves. However, it remains a mystery how the brain creates the conscious experience and what area of the brain is responsible.

Aug 15, 2022

Neuromorphic Chip Gets $1 Million in Pre-Orders

Posted by in categories: computing, neuroscience

“We are aiming to provide capabilities in the tens to hundreds of milliwatts range, depending on the use case,” Makhijani said.

Compared to the first–gen chip GrAI One, the third–gen GrAI VIP is slightly physically smaller at 7.6 × 7.6 mm, but the company has skipped a process node and migrated to TSMC 12 nm. The chip has slightly fewer neuron cores, 144 compared to 196, but each core is bigger. The result is a jump from 200,000 neuron cores (250,000 parameters) to around 18 million neurons for a total of 48 million parameters. On–chip memory has jumped from 4 MB to 36 MB.

An M.2 hardware development kit featuring GrAI VIP is available now, shipping with GrAI Matter’s GrAI Flow software stack and model zoo for image classification, object detection, and image segmentation.

Aug 15, 2022

How researchers use new tools to map the structure and function of the brain

Posted by in categories: health, neuroscience

Comotion_design/iStock.

The U.S. Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative is a collaboration among the National Institutes of Health, Defense Advanced Research Projects Agency, National Science Foundation, Food and Drug Administration, Intelligence Advanced Research Projects Activity, and others. Since its inception in 2013, its goal has been to develop and use new technologies to examine how each neuron and neural circuit come together to “record, process, utilize, store, and retrieve vast quantities of information, all at the speed of thought.”

Aug 15, 2022

HUMAN AUGMENTATION EXAMPLES — Webinar at Brave New World | Peter Joosten MSc

Posted by in categories: biotech/medical, genetics, neuroscience

Human Augmentation Examples. What are examples of augmentations to the human body? Should we allow such augmentation methods and technologies? What are dangers, and risks involved? How can society benefit from these developments?

On Brave New World conference 2020 I gave this webinar with the title: ‘The Human Body. The Next Frontier’.

Continue reading “HUMAN AUGMENTATION EXAMPLES — Webinar at Brave New World | Peter Joosten MSc” »

Aug 14, 2022

Human cognition-enhancing CORD7 mutation increases active zone number and synaptic release

Posted by in categories: biotech/medical, engineering, neuroscience, singularity

This article tells of possible way to increase brain intelligence through a certain mutation which in theory could be altered for biological singularity like effects in the future.


Humans carrying the CORD7 (cone-rod dystrophy 7) mutation possess increased verbal IQ and working memory. This autosomal dominant syndrome is caused by the single-amino acid R844H exchange (human numbering) located in the 310 helix of the C2A domain of RIMS1/RIM1 (Rab3-interacting molecule 1). RIM is an evolutionarily conserved multi-domain protein and essential component of presynaptic active zones, which is centrally involved in fast, Ca2+-triggered neurotransmitter release. How the CORD7 mutation affects synaptic function has remained unclear thus far. Here, we established Drosophila melanogaster as a disease model for clarifying the effects of the CORD7 mutation on RIM function and synaptic vesicle release.

To this end, using protein expression and X-ray crystallography, we solved the molecular structure of the Drosophila C2A domain at 1.92 Å resolution and by comparison to its mammalian homolog ascertained that the location of the CORD7 mutation is structurally conserved in fly RIM. Further, CRISPR/Cas9-assisted genomic engineering was employed for the generation of rim alleles encoding the R915H CORD7 exchange or R915E, R916E substitutions (fly numbering) to effect local charge reversal at the 310 helix. Through electrophysiological characterization by two-electrode voltage clamp and focal recordings we determined that the CORD7 mutation exerts a semi-dominant rather than a dominant effect on synaptic transmission resulting in faster, more efficient synaptic release and increased size of the readily releasable pool but decreased sensitivity for the fast calcium chelator BAPTA.

Continue reading “Human cognition-enhancing CORD7 mutation increases active zone number and synaptic release” »