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Category: neuroscience – Page 339

Toxic RNAs: The Hidden Cause of Neuron Death in Alzheimer’s Uncovered

A new Northwestern Medicine study shows that RNA interference may play a key role in Alzheimer’s. For the first time, scientists have identified short strands of toxic RNAs that contribute to brain cell death and DNA damage in Alzheimer’s and aged brains. Short strands of protective RNAs are decreased during aging, the scientists report, which may allow Alzheimer’s to develop.

The study also found that older individuals with a superior memory capacity (known as SuperAgers) have higher amounts of protective short RNA strands in their brain cells. SuperAgers are individuals aged 80 and older with a memory capacity of individuals 20 to 30 years younger.

“Nobody has ever connected the activities of RNAs to Alzheimer’s,” said corresponding study author Marcus Peter, the Tom D. Spies Professor of Cancer Metabolism at Northwestern University Feinberg School of Medicine. “We found that in aging brain cells, the balance between toxic and protective sRNAs shifts toward toxic ones.”

Rhythms of the Mind: MIT Neuroscientists Reveal Universal Brain Wave Patterns

Across mammalian species, brain waves are slower in deep cortical layers, while superficial layers generate faster rhythms.

Throughout the brain’s cortex, neurons are arranged in six distinctive layers, which can be readily seen with a microscope. A team of MIT neuroscientists has now found that these layers also show distinct patterns of electrical activity, which are consistent over many brain regions and across several animal species, including humans.

The researchers found that in the topmost layers, neuron activity is dominated by rapid oscillations known as gamma waves. In the deeper layers, slower oscillations called alpha and beta waves predominate. The universality of these patterns suggests that these oscillations are likely playing an important role across the brain, the researchers say.

Unveiling Evolution’s Secrets: Scientists Discover Mathematical Connection Between Chickens, Frogs, and Fish

One of the fundamental and timeless questions of life concerns the mechanics of its inception. Take human development, for example: how do individual cells come together to form complex structures like skin, muscles, bones, or even a brain, a finger, or a spine?

Although the answers to such questions remain unknown, one line of scientific inquiry lies in understanding gastrulation — the stage at which embryo cells develop from a single layer to a multidimensional structure with a main body axis. In humans, gastrulation happens around 14 days after conception.

It’s not possible to study human embryos at this stage, so researchers at the University of California San Diego, the University of Dundee (UK), and Harvard University were able to study gastrulation in chick embryos, which have many similarities to human embryos at this stage.

These 3 Personality Traits Are Linked to a Lower Risk of Dementia

Individuals with personality traits such as conscientiousness, extraversion, and positive affect are less likely to be diagnosed with dementia than those with neuroticism and negative affect, according to a new analysis by researchers at the University of California, Davis, and Northwestern University. The difference was not linked to physical damage to brain tissue found in dementia patients, but more likely to how certain personality traits help people navigate dementia-related impairments.

The work was recently published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.

Previous studies have tried to establish links between personality traits and dementia, but these were mostly small and represented only specific populations, said Emorie Beck, assistant professor of psychology at UC Davis and first author on the paper.

Neural Connectivity: A Universal Network Phenomenon

Summary: A groundbreaking study by physicists and neuroscientists reveals that the connectivity among neurons stems from universal networking principles, not just biological specifics.

Analyzing various model organisms, researchers found a consistent “heavy-tailed” distribution of neural connections, guided by Hebbian dynamics, indicating that neuron connectivity relies on general network organization.

This discovery, transcending biology, potentially applies to non-biological networks like social interactions, offering insights into the fundamental nature of networking.

New gut-brain circuits found for sugar and fat cravings

Understanding why we overeat unhealthy foods has been a long-standing mystery. While we know food’s strong power influences our choices, the precise circuitry in our brains behind this is unclear. The vagus nerve sends internal sensory information from the gut to the brain about the nutritional value of food. But, the molecular basis of the reward in the brain associated with what we eat has been incompletely understood.

A study published in Cell Metabolism, by a team from the Monell Chemical Senses Center, unravels the internal neural wiring, revealing separate fat and sugar craving pathways, as well as a concerning result: Combining these pathways overly triggers our desire to eat more than usual.

“Food is nature’s ultimate reinforcer,” said Monell scientist Guillaume de Lartigue, Ph.D., lead author of the study. “But why fats and sugars are particularly appealing has been a puzzle. We’ve now identified in the gut rather than taste cells in the mouth are a key driver. We found that distinct gut– pathways are recruited by fats and sugars, explaining why that donut can be so irresistible.”

Chinese lab crafts mutant COVID-19 strain with 100% kill rate in ‘humanized’ mice: ‘Surprisingly’ rapid death

Factor in along w/ weird stories of secret labs in places like California.

GX_P2V had infected the lungs, bones, eyes, tracheas and brains of the dead mice, the last of which was severe enough to ultimately cause the death of the animals.

In the days before their deaths, the mice had quickly lost weight, exhibited a hunched posture, and moved extremely sluggishly.

Most eerie of all, their eyes turned completely white the day before they died.