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Category: neuroscience – Page 332

Synaptic Transmission: Not a One-Way Street for Key Brain Synapse in the Hippocampus

Key synapse acts as a “smart teacher,” sending messages against the usual flow of information in the brain.

Information flows in a well-defined direction in the brain: Chemical and electrical signals are passed from one neuron to the other across the synapse, from the pre-synaptic to the post-synaptic neuron. Now, Peter Jonas and his group at the Institute of Science and Technology Austria (IST Austria) show that information also travels in the opposite direction at a key synapse in the hippocampus, the brain region responsible for learning and memory.

At the so-called mossy fiber synapse, the post-synaptic CA3 neuron influences how the pre-synaptic neuron, the so-called mossy fiber neuron, fires. “We have shown, for the first time, that a retrograde information flow is physiologically relevant for pre-synaptic plasticity,” says Yuji Okamoto, a postdoc in the group of Peter Jonas at IST Austria and co-first author of the paper published in Nature Communications.

Chickadees have unique neural ‘barcodes’ for memories of stashing away food

Black-capped chickadees have extraordinary memories that can recall the locations of thousands of morsels of food to help them survive the winter. Now scientists at Columbia’s Zuckerman Institute have discovered how the chickadees can remember so many details: they memorize each food location using brain cell activity akin to a barcode. These new findings may shed light on how the brain creates memories for the events that make up our lives.

Mind Machine Interfaces

The ability to link mind and machine has long been the realm of science fiction, but now improvements in our understanding may allow us to network brain to computer in the near future. Companies like Neurolink have begun to explore how to link our neurons to machine, and we’ll explore now such neural interfaces might function and how they might change our lives.

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Neuropeptide Lacking in Diabetics Promotes Wound Healing

“In adults with diabetes alone—where poor blood flow can lead to quickly worsening wounds that are often very slow or impossible to heal—the lifetime risk of developing a diabetic foot ulcer (DFU), the most common diabetes-related wound, is 20–35 percent and this number is rising with increased longevity and medical complexity of people with diabetes,” stated lead author, Yen-Zhen Lu, PhD, an investigator at ARMI.

Nociceptors— neurons that sense pain, tissue damage, and inflammation, among other functions— respond to wounds by producing a neuropeptide called calcitonin gene-related peptide (CGRP). “Nociceptor endings grow into injured skin and muscle tissues and signal to immune cells through the neuropeptide CGRP during the healing process,” the authors wrote. Immune cell response in neutrophils, monocytes, and macrophages are modified to encourage active repair in the region.

Individuals with diseases like diabetes or elderly people have reduced production of CGRP, leading to poor, inefficient, or incomplete wound healing. The new study explores the impact of CGRP alone by introducing it into diabetic mice as well as mice without nociceptors. “Delivery of an engineered version of CGRP accelerated wound healing and promoted muscle regeneration,” the authors wrote. “Remarkably, this neuropeptide acts on immune cells to control them, facilitating tissue healing after injury,” added co-author Mikaël Martino, PhD, associate professor, ARMI.

Neurological Shadows: The Cognitive Costs of Sleep Apnea Unraveled

A new study indicates a link between sleep apnea and increased memory or thinking problems, based on self-reported data from over 4,000 participants.

People who experience sleep apnea may be more likely to also have memory or thinking problems, according to a preliminary study that will be presented at the American Academy of Neurology’s 76th Annual Meeting taking place April 13–18, 2024, in person in Denver and online. The study shows a positive association but did not determine whether sleep apnea causes cognitive decline.

Sleep apnea is when people stop and restart breathing repeatedly during sleep which can lower oxygen levels in the blood. Symptoms include snorting, gasping, and breathing pauses. People with the disorder may also experience morning headaches or have trouble focusing on tasks.

Chilling Findings: Scientists Shed Light on How the Brain Perceives Temperature

Christian Lemon, Ph.D., an associate professor in the School of Biological Sciences at the University of Oklahoma, often thinks about temperature sensation and the brain when eating a chilled mint cookie. Now, research from his lab examining oral temperature perception has been published in The Journal of Neuroscience.

In their research, Lemon’s team investigates how cold receptors in the mouth are activated by cooling temperatures, how those signals are transmitted to the brain and how those transmissions are generated into a cooling sensation.

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