Lifeboat Foundation

Targeting calcium signaling in neurons represents a promising therapeutic approach for treating a rare form of schizophrenia, according to a Northwestern Medicine study published in Biological Psychiatry.

“This is the first time that human neurons are made and characterized from schizophrenia patients with the 16p11.2 duplication, one of the most prominent genetic risk factors in schizophrenia, and the first time that calcium signaling is found as a central abnormality in schizophrenia neurons,” said Peter Penzes, Ph.D., the Ruth and Evelyn Dunbar Professor of Psychiatry and Behavioral Sciences and senior author of the study.

Schizophrenia is characterized by auditory and visual hallucinations, delusions, and trouble with forming and sorting thoughts, which severely impacts productivity and overall quality of life. The disease, which affects roughly one percent of the general population, has strong genetic associations, however the exact genes involved are unknown.

So you have that to look forward to.

A Quebec hospital adopts a novel use of VR to help patients with anxiety, phobias and pain.

In a newswire release today, the Fondation de l’Hôtel-Dieu d’Alma (the Alma Hospital Foundation) announced the launch of a virtual reality (VR) project aimed at improving the mental health of those experiencing increasing anxiety. The Alma Hospital is a regional health centre for the area of Lac St. Jean and the Saguenay River valley to the north of Quebec City.

Jean Lamoureux, the hospital’s Executive Director states, “The number of requests for mental-health consultations is estimated to have increased by 30 to 40 percent during the pandemic. These needs are urgent…and, thanks to the innovation of Paperplane Therapeutics and TELUS, we will transform the way health services are delivered, while having a significant positive impact on patient well-being through technology.”

Continue reading “Quebec Hospital Using Virtual Reality to Address Increasing Mental Health Issues from the Pandemic” »

Very old brain, some ancient philosophy maybe…

A fossilised fish originally dug up more than a century ago in an English coal mine has been shown to hold the world’s oldest brain in a vertebrate animal.

CT scans revealed the new internal features including a brain and cranial nerves about 2 centimetres long.

Continue reading “Oldest brain in a backboned animal found in fish fossil” »

Advancing Geroscience & Gerotherapeutics — Dr. Nir Barzilai, MD, Albert Einstein College of Medicine.

Dr. Nir Barzilai, MD (https://www.einsteinmed.edu/faculty/484/nir-barzilai/) is the Director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. He is the Ingeborg and Ira Leon Rennert Chair of Aging Research, professor in the Departments of Medicine and Genetics, and member of the Diabetes Research Center and of the Divisions of Endocrinology & Diabetes and Geriatrics.

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Researchers at Eötvös Loránd University have investigated whether the perception of time changes with age, and if so, how, and why we perceive the passage of time differently. Their study was published in Scientific Reports.

Time can play tricks on us. Many of us experienced the illusion that those long summers during childhood felt so much longer than the same 3 months feel like now as an adult. While we can argue why one summer may appear longer than the other and how the perception of time can compress and dilate durations depending on various factors, we can easily set up an experiment to gain more insights.

The researchers just did that. They asked how eventfulness affects our duration estimates when probing at different milestones during our cognitive development. They set aside three age groups, 4–5, 9–10, and 18 years and older, and made them watch two videos, 1 minute each. The two videos were extracted from a popular animated series, balanced in visual and acoustic features, except for one feature: eventfulness.

Summary: Using advanced neuroimaging techniques, researchers discovered distant brain regions oscillate together in time.

Source: champalimaud centre for the unknown.

It’s been over 20 years since neuroimaging studies – using functional magnetic resonance imaging (fMRI), a widely-used technology to capture live videos of brain activity – have been detecting brain-wide complex patterns of correlated brain activity that appear disrupted in a wide range of neurological and psychiatric disorders.

𝐏𝐫𝐨𝐥𝐢𝐟𝐢𝐜 𝐚𝐮𝐭𝐢𝐬𝐦 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡𝐞𝐫 𝐡𝐚𝐬 𝐭𝐰𝐨 𝐝𝐨𝐳𝐞𝐧 𝐩𝐚𝐩𝐞𝐫𝐬 𝐫𝐞𝐭𝐫𝐚𝐜𝐭𝐞𝐝

An autism researcher lost two dozen papers to retraction in January, eight years after the publisher was made aware of potentially troubling editorial practices. Elsevier, the publisher, cited undisclosed conflicts of interest, duplicated methodology and a “compromised” peer-review process as reasons for the retractions.

The papers were published in Research in Developmental Disabilities and Research in Autism Spectrum Disorders between 2013 and 2014 — a period when Johnny Matson, then professor of psychology at Louisiana State University (LSU) in Baton Rouge and an author on all of the papers, was editor-in-chief of both journals.

Continue reading “Prolific autism researcher has two dozen papers retracted” »

Rejuvenating an older person’s blood may now be within reach, based on recent findings from Passegué’s lab published in Nature Cell Biology(link is external and opens in a new window).

Passegué, with her graduate student Carl Mitchell, found that an anti-inflammatory drug, already approved for use in rheumatoid arthritis, can turn back time in mice and reverse some of the effects of age on the hematopoietic system.

Nature article:

Continue reading “Will Revitalizing Old Blood Slow Aging?” »