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Detecting the body’s magnetic fields with a low-power Ramsey-based magnetometer

Our bodies generate extremely weak magnetic fields as electric currents flow through the heart, brain and other tissues. These signals are used in magnetocardiography and magnetoencephalography to assess heart function and brain activity, respectively. These fields can be detected at room temperature using diamond sensors containing nitrogen-vacancy (NV) centers, in which a carbon atom is replaced by a nitrogen atom adjacent to an empty lattice site.

However, conventional NV-center sensors typically require watt-level lasers to detect the extremely weak biomagnetic fields, which are usually below the picotesla level. These high-power lasers generate significant heat, limiting how close the sensor can be placed to biological tissue. Since biomagnetic fields rapidly weaken with distance, overcoming thermal and close-proximity challenges is essential for practical biomagnetic sensing.

A research team led by Professor Takayuki Iwasaki from the Department of Electrical and Electronic Engineering, School of Engineering, Institute of Science Tokyo, Japan, has developed a diamond quantum magnetometer using a low-power laser of just 210 mW, a light-trapping diamond waveguide and a compact microwave antenna. The new sensor limits its temperature rise to only 13 K while allowing it to be placed just 2 mm (0.08 inches) from the sample, enabling close-proximity biomagnetic measurements without compromising thermal safety.

Brain-penetrating nanoparticles, ultrasound and microbubbles show promise in treating glioblastoma

University of Virginia Comprehensive Cancer Center scientists have developed a promising new experimental approach to targeting glioblastoma, the most common and deadliest brain cancer. The approach could overcome many of the limitations of treatments using existing drugs.

UVA’s Roger Abounader, MD, Ph.D., and colleagues have identified “microRNAs” that can simultaneously suppress multiple malfunctioning genes responsible for glioblastoma’s formation and growth. The scientists use a combination of brain-penetrating nanoparticles, focused ultrasound waves and microbubbles to deliver the miRNAs through the brain’s natural protective barrier—a barrier that typically blocks treatments for tumors and neurodegenerative diseases. The study is published in the Journal of Clinical Investigation.

“This new approach could help target numerous molecules that promote cancer growth, including those for which no drugs exist, at the same time to achieve better therapies,” said Abounader, a professor at UVA’s School of Medicine, Department of Microbiology, Immunology and Cancer Biology, Comprehensive Cancer Center and Center for RNA Science and Medicine. “We are hoping to translate our findings into future clinical trials for patients with glioblastoma and other brain tumors.”

Gut microbial metabolites may shape vulnerability to stress-related mental disorders

Gut microbiome-derived metabolites may influence stress-related mental disorders through neural, immune, endocrine, and epigenetic pathways. Evidence is strongest for depression and preclinical models, while larger longitudinal human studies are needed to establish causality and clinical value.

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