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Unlocking immortality: the science of reversing aging

When it comes to human longevity, you might envision nanobots helping our bodies operate more efficiently. But our bodies are biological machines in their own right, evolved to handle any situation in the real world from illness to cold to hunger. Our bodies heal themselves, and they can be programmed to do so if we understood that language better.

This video talks about DNA and genes, and the epigenetic mechanisms that read that information. The epigenetic clock is one way to measure the age of cells, and this can be reversed with current technologies. We discuss experiments by David Sinclair, which made blind mice see again, and experiments by Greg Fahy, which regenerated the immune system of humans and reset their cellular age by 2 years.

Asking our bodies to heal themselves could be one of the largest medical breakthroughs ever, instead of trying mainly chemical means of medication. And it has significant implications for whether or not we can achieve longevity escape velocity and continue to live more or less indefinitely. This promises to be a very interesting topic.

#aging #longevity #science.

The science of super longevity | Dr. Morgan Levine.
https://www.youtube.com/watch?v=B_CqKVU19ec.

Groundbreaking Research on Anti-Aging: Unlock the Secrets to Longevity | David Sinclair.

Flexible sensors made of nanomaterials—and the metaverse—will redefine how people live in the future

Researchers from Changchun University of Science and Technology (CUST) and City University of Hong Kong (CityU) have conducted a survey on the fabrication of flexible sensors using nanomaterials of different dimensions and the triggering methods of interaction between these sensors and virtual reality applications.

The review, published in the International Journal of Extreme Manufacturing (IJEM), highlights the recent advancements in -based flexible sensors (NMFSs) involving various nanomaterial frameworks such as nanoparticles, nanowires, and nanofilms.

Different triggering mechanisms for interaction between NMFSs and metaverse/virtual reality applications are discussed, e.g., skin-mechanics-triggered, temperature-triggered, magnetically triggered, and neural-triggered interfaces.

Free-space nanoprinting beyond optical limits to create 4D functional structures

Two-photon polymerization is a potential method for nanofabrication to integrate nanomaterials based on femtosecond laser-based methods. Challenges in the field of 3D nanoprinting include slow layer-by-layer printing and limited material options as a result of laser-matter interactions.

In a new report now on Science Advances, Chenqi Yi and a team of scientists in Technology Sciences, Medicine, and Industrial Engineering at the Wuhan University China and the Purdue University U.S., showed a new 3D nanoprinting approach known as free-space nanoprinting by using an optical brush.

This concept allowed them to develop precise and spatial writing paths beyond optical limits to form 4D functional structures. The method facilitated the rapid aggregation and solidification of radicals to facilitate polymerization with increased sensitivity to , to provide high accuracy, free-space painting much like Chinese brush painting on paper.

Pig plasma to live longer?

A quickie about E5.


Hello, i am back! Blood, sweat and tears have been shed these past months of absence. But enough sweating was done during the summer, tears have already been shed, so that just leaves me with blood. And whether taking a part of blood (plasma) and injecting it into old animals is enough for rejuvenation. That’s right, many of you may remember, earlier this year i made a video on the oldest living rat.- and now we have some updates: in particular, (i) what actually were the rats given, and (ii) what changes were seen, showing both some DNAm and glycan age data.

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TIMESTAMPS:

Scientists create a novel quantum platform using atoms

The method is still at its basic stage but multiple such microscopes could be pooled up to build a larger quantum computer.

Researchers at the IBS Center for Quantum Nanoscience (QNS) in Seoul, South Korea, have successfully demonstrated using a scanning tunneling microscope (STM) to perform quantum computation using electrons as qubits, a press release said.

Quantum computing is usually associated with terms such as atom traps or superconductors that aid in isolating quantum states or qubits that serve as a basic unit of information. In many ways, everything in nature is quantum and can be used to perform quantum computations as long as we can isolate its quantum states.

New Ukrainian nanotech ‘cloak’ can hide people from drones

An unnamed Ukrainian scientist has allegedly developed a new material that can mask heat signatures of troops and gear from Russian drones.

“Necessity is the mother of all inventions,” as the saying goes, and this saying has never been more accurate than when applied to wargear. The latest exemplar of this is a new “invisibility cloak” developed by a Ukrainian material scientist to help protect Ukrainians from Russian drones. As reported by inews.


Aurumarcus/iStock.

Hidden in plain sight.

Beyond Treatment: FendX Nanotechnology as the Future of Preventative Biotech

Contrary to existing antimicrobial coatings, which function by eliminating microorganisms upon contact over some adequate duration of time, the technology developed by FendX takes a preventative approach. Utilizing nanotechnology to develop film and spray protective coatings that prevent microbial adherence to surfaces, thereby minimizing the potential for transmission. This is a significant departure from reactive coating surfaces in the market, offering a proactive method for reducing the occurrence and spread of HAIs.

REPELWRAP™ film, is FendX’s lead product in development and is with their manufacturer who is gearing up to conduct pilot runs on their commercial manufacturing line to create intermediate films for testing. FendX is also developing a spray-based product using their patent-pending nanotechnology. This spray offers the same preventative measures against microbial adherence and has the potential to be more versatile and easier-to-apply to surfaces. It not only demonstrates the same repelling properties but also effectively inactivates any residual microorganisms on the coated surface.

FendX is focused on healthcare settings, but is also exploring potential applications in other multiple billion high-traffic industries. It is anticipated that FendX’s future protective coatings can be applied to various high-touch surfaces: from bed rails and IV poles in healthcare to potential handrails in public transport systems to door handles in restaurants and public bathrooms. Given that the technology inhibits microbial adherence, it has the potential to significantly reduce the spread of pathogens in virtually any setting where human interaction with surfaces occurs. This broad applicability signifies that the market opportunity could be vastly larger than the projected $7.6 billion for antimicrobial coatings by 2025, opening doors to various industries and settings.

New research may make future design of nanotechnology safer with fewer side effects

A new study, published in Nature Nanotechnology, may offer a strategy that mitigates negative side effects associated with intravenous injection of nanoparticles commonly used in medicine.

“Nanotechnology’s main advantage over conventional medical treatments is its ability to more precisely target tissues, such as targeted by chemotherapy. However, when nanoparticles are injected, they can activate part of the called complement,” said senior author Dmitri Simberg, Ph.D., professor of Nanomedicine and Nanosafety at the University of Colorado Skaggs School of Pharmacy on the University of Colorado Anschutz Medical Campus.

Complement is a group of proteins in the immune system that recognize and neutralize bacteria and viruses, including nanoparticles which are foreign to the body. As a result, nanoparticles are attacked by triggering side effects that include shortness of breath, elevated heart rate, fever, hypotension, and, in rare cases, anaphylactic shock.

Biocompatible focused ultrasound delivers cancer drugs on target

Remote control of chemical reactions in biological environments could enable a diverse range of medical applications. The ability to release chemotherapy drugs on target in the body, for example, could help bypass the damaging side effects associated with these toxic compounds. With this aim, researchers at California Institute of Technology (Caltech) have created an entirely new drug-delivery system that uses ultrasound to release diagnostic or therapeutic compounds precisely when and where they are needed.

The platform, developed in the labs of Maxwell Robb and Mikhail Shapiro, is based around force-sensitive molecules known as mechanophores that undergo chemical changes when subjected to physical force and release smaller cargo molecules. The mechanical stimulus can be provided via focused ultrasound (FUS), which penetrates deep into biological tissues and can be applied with submillimetre precision. Earlier studies on this method, however, required high acoustic intensities that cause heating and could damage nearby tissue.

To enable the use of lower – and safer – ultrasound intensities, the researchers turned to gas vesicles (GVs), air-filled protein nanostructures that can be used as ultrasound contrast agents. They hypothesized that the GVs could function as acousto-mechanical transducers to focus the ultrasound energy: when exposed to FUS, the GVs undergo cavitation with the resulting energy activating the mechanophore.

Chemistry Nobel Prize goes to quantum dots that guide surgeons

From LED lights to medical imaging, quantum dots have many varied applications.

The creation of quantum dots earned its developers the Nobel Prize in Chemistry 2023, an invention that could have also been a contender for the Physics Prize. These tiny elements of nanotechnology, which are so miniature that their size dictates their properties, are today used in many useful and practical applications and have even been reported to direct surgeons as they tackle tricky tumor tissue.


Nobel Prize/Twitter.

Governed by quantum phenomena.