Ignoring notifications reshapes dopamine signaling and strengthens the prefrontal cortex, improving focus, impulse control, and long-term brain health.
Kali Linux has released version 2025.4, its final update of the year, introducing three new hacking tools, desktop environment improvements, the preview of Wifipumpkin3 in NetHunter, and enhanced Wayland support.
Kali Linux is a distribution designed for cybersecurity professionals and ethical hackers to perform red-teaming, penetration testing, security assessments, and network research.
The distribution is available as an installable operating system or a live environment and supports a wide range of hardware, including Raspberry Pi devices and compatible Android phones through Kali NetHunter.
This issue’s cover features work by Alberto Siddu & team on the promotion of synapse formation in human neurons by free amyloid-beta peptides, in contrast to aggregated forms that are synaptotoxic:
The image shows a human induced neuron exposed to a nontoxic concentration of amyloid-beta42 peptide, revealing enhanced synaptogenesis, visible as synaptic puncta along the dendritic arbor.
Address correspondence to: Alberto Siddu, Lorry Lokey Stem Cell Building, 265 Campus Dr., Room G1015, Stanford, California 94,305, USA. Phone: 650.721.1418; Email: [email protected]. Or to: Thomas C. Südhof, Lorry Lokey Stem Cell Building, 265 Campus Dr., Room G1021, Stanford, California 94,305, USA. Phone: 650.721.1418; Email: [email protected].
Last year, a research team led by UCLA achieved a milestone scientists had pursued for half a century. They succeeded in making radioactive thorium nuclei interact with light by absorbing and emitting photons, similar to how electrons behave inside atoms. First envisioned by the group in 2008, the breakthrough is expected to transform precision timekeeping and could significantly improve navigation systems, while also opening the door to discoveries that challenge some of the most basic constants in physics.
The advance comes with a major limitation. The required isotope, thorium-229, exists only as a byproduct of weapons-grade uranium, making it extremely rare. Researchers estimate that just 40 grams of this material are currently available worldwide for use in nuclear clock research.
A new study now shows a way around this obstacle. An international collaboration led by UCLA physicist Eric Hudson has developed an approach that uses only a small fraction of the thorium needed in earlier experiments, while delivering the same results previously achieved with specialized crystals. Described in Nature, the technique is both straightforward and low cost, raising the possibility that nuclear clocks could one day be small and affordable enough to fit into everyday devices like phones or wristwatches. Beyond consumer electronics, the clocks could replace existing systems used in power grids, cell phone towers, and GPS satellites, and may even support navigation where GPS is unavailable, such as in deep space or underwater.
This Commentary by Md Saidur Rahman, Kyeong A. So & Jae-Wook Jeong discusses Sylvia C. Hewitt et al.: https://doi.org/10.1172/JCI193212
1Department of Obstetrics, Gynecology & Women’s Health, University of Missouri School of Medicine, Columbia, Missouri, USA.
2Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, Republic of Korea.
Address correspondence to: Jae-Wook Jeong, 1,030 Hitt Street, NextGen Precision Health Building, Columbia, Missouri 65,211, USA. Phone: 573.884.1882; Email: [email protected].
Researchers have made a major advance in quantum computing with a new device that is nearly 100 times smaller than the diameter of a human hair.
Published in the journal Nature Communications, the breakthrough optical phase modulators could help unlock much larger quantum computers by enabling efficient control of lasers required to operate thousands or even millions of qubits—the basic units of quantum information.
Critically, the team of scientists have developed these devices using scalable manufacturing, avoiding complex, custom builds in favor of those used to make the same technology behind processors already found in computers, phones, vehicles, home appliances—virtually everything powered by electricity (even toasters).
Here, Conny Gysemans & team find variable patient responses align with specific immune gene signatures, offering a tool to predict treatment success or resistance.
Address correspondence to: Conny Gysemans, Leuven Diabetes Lab, Clinical and Experimental Endocrinology (CEE), CHROMETA, KU Leuven, Leuven, Belgium. Phone: 32.16.377454; Email: [email protected].
Harmeet Malhi & team discover ER-stress mediated S100A11 upregulation drives progression of fatty liver disease, revealing a new target for future treatments:
The figure shows reduction within the high-fat,-fructose, and-cholesterol,-lipotoxicity-influenced enhancer (FFC-LIE) mouse groups compared with FFC-scramble controls.
Address correspondence to: Harmeet Malhi, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55,905, USA. Phone: 507.284.0686; Email: [email protected].
Boyle, 85 Commercial Road, Melbourne, Victoria, Australia. Phone: 61.3.9282.2111; Email: [email protected].
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1Burnet Institute, Melbourne, Victoria, Australia.