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Category: life extension – Page 772

Hacking sleep: Meet the transhumanists making sleep obsolete

Not everyone wants to sleep in. A growing transhumanism community wants to sleep less, and better, and they’re going to great lengths to make it happen.

For those unaware, transhumanism is an intellectual and cultural movement that aims to improve the human condition, to push beyond our biological limitations, largely through technological advancements. They’re particularly focused on extreme longevity. But with treatments for an extended healthy life still works in progress (and playing out on a very long timeline), some transhumanists have turned their attention to sleep.

The average well-rested person sleeps eight hours a day. The average American lives 79 years. That’s a little more than just 50 years being awake. Life is much shorter than you realized — at least if you agree with your typical sleep-hacker that sleeping is wasted downtime.

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Alzheimer’s: One Disease? « Michael Fossel

Another excellent blog by Dr Michael fossel PhD, md. Alzheimer’s, Parkinson’s and other related diseases could be treated potentially using telomerase.

Alzheimer’s: One Disease?

Date posted: 25.08.2015.

Most of us have wondered about what causes Alzheimer’s. As commonly happens, we stumble badly when we make assumptions, even in asking questions, let alone in trying to answer those questions. The question “what causes Alzheimer’s?” presupposes that there is a single such disease (Alzheimer’s) and that we can define it well enough to ask about “its” cause. Neither of these is probably an accurate assumption. The reality is that there is considerable difficulty in agreeing on the “hallmarks” (the pathognomonic characteristics that define AD) and the “boundaries” between AD and other somewhat similar diseases on the differential diagnosis. Comparing Alzheimer’s to many other age-related neurological diseases can be humbling – and it should be. Small wonder we have so much trouble understanding the cause, let alone finding a cure when we don’t really know what we’re looking at.

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In The Genes: Longevity Secrets From Long-Lived Smokers

If you want to increase your risk of multiple diseases, then smoking is one of surest ways to do it; it can even accelerate aging. So how do some long-term smokers beat the odds?

Long-lived smokers are fascinating. Not only do they live a long time, but they also appear unaffected by their habit. For most of us, smoking has been confirmed to be ‘toxic’, but these outliers somehow overcome this. So how can these people reach old age despite having smoked most of their life? Scientists predicted they must have some unusual genes, and they were right.

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Filling a void in stem cell therapy

Stem cells coming along nicely, Stanford demonstrate how creating artificial stem cell niches improve grafting and regeneration of bone and it should have a broad application for other tissues. Properly developed we could regenerate organs and tissues by injecting enough stem cells in these manufactured protective niches.

One could potentially take it a stage further and modify the stem cells with genes of interest to make them more robust. Ex-vivo cell manipulation is also considerably cheaper than in-vivo therapy.

New porous hydrogel could boost success of some stem cell-based tissue regeneration, researchers say.

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Can A Healthy Gut Help You Live Longer?

Our gut and the microbiome play a crucial role in our health, but could better understanding of that role help us avoid disease and live longer?

The microbiome weighs 2–3 pounds and contains 10 times more cells than our own, but we’ve neglected our microbial tenants for a long time. These little denizens help us break down food, provide key nutrients and even play a role in inflammation and the integrity of our intestinal tract. It’s no surprise then that fermented foods and probiotics are gaining popularity as we become more aware of how important our gut is. Recent evidence even links poor digestive health to chronic inflammation and Parkinson’s disease.

New research suggests that both gut integrity, and the amount and type of bacteria that reside within it, can actually predict an individual’s health. They may even quicken or slow the pace of aging.

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Curing Alzheimer’s

Dr Michael Fossel is a PhD and MD heading up telomerase research and therapy and has kindly written a blog article for Bioviva detailing the work both they and his company Telocyte are doing to fight back against Alzheimer’s.

How Alzheimer’s Can Be Prevented and Cured…

Michael Fossel, MD, PhD

As I said in my medical textbook on aging, “If age is a thief, then the greatest treasure we lose is ourselves.” We fear Alzheimer’s not simply because it takes away our health, but because it steals our souls.

Once, we thought it was simply “old age” that gradually killed the cells that carry information and memory. These are brain cells that make us who we are and define our consciousness.

Only in the past two decades, have we gradually come to realize that it’s not the neurons, which are merely the innocent bystanders in the tragedy,

but the microglial cells that cause the disease. It’s our microglia, not our neurons that steal our very souls.

Alzheimer’s disease begins in our glial cells. These cells together form.

90% of our brains, while neurons are only a small minority in the nervous system.

Continue reading “Curing Alzheimer’s” | >

Scientists Hope To Resurrect A Dead Girl Who Wanted To Live Inside A Computer

Kim Suozzi died at age 23 from glioblastoma — a deadly brain tumour.

When she died in 2013, she made sure her fight for survival, albeit an unusual one, would not be forgotten.

She wanted to live forever through a computer and chose to have her brain frozen in the hopes that it may one day be resurrected and transformed into digital code.

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Aging Causes Muscle Weakness And Atrophy, But Can We Treat It?

Everything starts to go downhill as we get older and muscle is no exception; even simple tasks become challenging as we lose bone and muscle. Now research has identified a protein behind this age-related decline and therapeutic molecules that can fight it, helping individuals stay healthy and strong for longer.

A team at the Univesity of Iowa has discovered that a protein called ATF4 might be behind muscular decline. ATF 4 is a transcription factor, which means it tells the body to activate or regulate certain genes. ATF4 seems to change skeletal muscle with age, reducing protein synthesis and overall mass.

”Many of us know from our own experiences that muscle weakness and atrophy are big problems as we become older”

What can we do about it?

Researchers also identified two molecules that dramatically reduce this age-related decline in mice: ursolic acid from apple peels, and tomatidine, present in green tomatoes. When elderly mice were fed either of these compounds, muscle mass was increased by 10% and muscle strength by 30% — essentially restoring their muscles to a youthful state.

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Scientists discover cause of and potential treatment for muscle weakness and loss due to aging

As we grow older, we lose strength and muscle mass. However, the cause of age-related muscle weakness and atrophy has remained a mystery.

Scientists at the University of Iowa have discovered the first example of a protein that causes and loss during aging. The protein, ATF4, is a transcription factor that alters gene expression in , causing reduction of , strength, and mass. The UI study also identifies two natural compounds, one found in apples and one found in green tomatoes, which reduce ATF4 activity in aged skeletal muscle. The findings, which were published online Sept. 3 in the Journal of Biological Chemistry, could lead to new therapies for age-related muscle weakness and atrophy.

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