ROCHESTER — How long can you stand on one leg?
The answer to that question is linked with aging and one’s risk of falling, new research out of Mayo Clinic finds. The paper “Age-related changes in gait, balance, and strength parameters: A cross-sectional study” appears in the journal PLOS ONE today, Oct. 23.
BIOHACKER Bryan Johnson who’s shelling out millions in his quest for immortality has revealed the exact steps he follows to reverse his hair loss and get rid of greys.
The tech-tycoon, 47, claimed he’s been able to grow a full head of hair despite being “genetically bald” through a mix of supplements, red light therapy and customised hair oil.
At one time, Bryan was best known for founding the payments company Braintree — but nowadays he’s making headlines for his very expensive quest to turn back the clock and become 18 again.
In this episode of the Longevity Optimization Podcast, Dr. DeGray discusses groundbreaking research in aging and longevity, focusing on combination therapies, the hallmarks of aging, and the potential of stem cell and gene therapies. He emphasizes the importance of rejuvenation over merely slowing aging and explores the role of the immune system in health. The conversation also touches on biological age testing, lifestyle factors, and the future of gene therapy in enhancing longevity.
Aubrey de Grey is a British biomedical gerontologist and the founder of the SENS Research Foundation. He is a leading advocate for regenerative medicine, focusing on reversing the effects of aging by repairing cellular damage. Known for his bold vision of life extension, de Grey believes that with advanced therapies, humans could significantly extend their lifespan. He is the co-author of Ending Aging, and his work continues to shape the future of longevity science.
Takeaways.
Combination therapies are crucial for understanding aging.
Rejuvenation may be easier than slowing down aging.
Stem cell therapies hold great promise for the future.
The immune system plays a significant role in aging.
Biological age testing can provide insights into health.
Gene therapy is a promising avenue for longevity research.
Lifestyle factors have limited impact on lifespan extension.
Understanding the hallmarks of aging is essential for interventions.
Preventative maintenance is key to longevity.
The future of aging research is bright with new technologies.
Chapters.
00:00 Introduction to Longevity and Aging Research.
The great George Church takes us through the revolutionary journey of DNA sequencing from his early groundbreaking work to the latest advancements. He discusses the evolution of sequencing methods, including molecular multiplexing, and their implications for understanding and combating aging.
We talk about the rise of biotech startups, potential future directions in genome sequencing, the role of precise gene therapies, the ongoing integration of nanotechnology and biology, the potential of biological engineering in accelerating evolution, transhumanism, the Human Genome Project, and the importance of intellectual property in biotechnology.
The episode concludes with reflections on future technologies, the importance of academia in fostering innovation, and the need for scalable developments in biotech.
00:00 Introduction to Longevity and DNA Sequencing.
01:43 George Church’s Early Work in Genomic Sequencing.
02:38 Innovations in DNA Sequencing.
03:15 The Evolution of Sequencing Methods.
07:41 Longevity and Aging Reversal.
12:12 Biotech Startups and Commercial Endeavors.
17:38 Future Directions in Genome Sequencing.
28:10 Humanity’s Role and Transhumanism.
37:23 Exploring the Connectome and Neural Networks.
38:29 The Mystery of Life: From Atoms to Living Systems.
39:35 Accelerating Evolution and Biological Engineering.
41:37 Merging Nanotechnology and Biology.
45:00 The Future of Biotech and Young Innovators.
47:16 The Human Genome Project: Successes and Shortcomings.
01:01:10 Intellectual Property in Biotechnology.
01:06:30 Future Technologies and Final Thoughts.
As Canadians brace for “vitamin D winter”—months when the sun’s angle is too low to produce the vitamin in the skin—a McGill University study explains why vitamin D deficiency early in life is associated with a higher risk of autoimmune diseases.
During childhood, the thymus helps train immune cells to distinguish between the body’s own tissues and harmful invaders. A vitamin D deficiency at that stage of life causes the thymus to age more quickly, the researchers discovered.
The study is published in the journal Science Advances.
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Researchers discovered that PLK1 triggers a process ensuring centromere preservation during cell division by activating the Mis18 complex and controlling CENP-A loading. This finding is key to understanding how cells correctly divide their genetic material, preventing diseases like cancer.
Scientists have resolved a decade-long mystery about the mechanism that maintains the centromere, the crucial region responsible for ensuring accurate DNA division during cell division.
A study revealed that a protein, known as PLK1, triggers a process that coordinates key proteins at the right place and time during cell division – ensuring each new cell has a centromere in the right location.