Toggle light / dark theme

Toothpaste significantly reduces dental plaque and inflammation throughout the body

Time to get the toothbrush out and brush for longevity!


For decades, research has suggested a link between oral health and inflammatory diseases affecting the entire body — in particular, heart attacks and strokes.

The results released today from a randomized trial of a novel plaque identifying toothpaste, (Plaque HD®), show statistically significant reductions in dental plaque and inflammation throughout the body. Inflammation throughout the body is accurately measured by high sensitivity C-reactive protein (hs-CRP), a sensitive marker for future heart attacks and strokes. These results, published today online ahead of print in the American Journal of Medicine, with an accompanying editorial by the editor-in-chief, show that Plaque HD®, produced statistically significant reductions in dental plaque and inflammation throughout the body as measured by hs-CRP.

In this trial, all randomized subjects were given the same brushing protocol and received a 60-day supply of toothpaste containing either Plaque HD® or an identical non-plaque identifying placebo toothpaste. To assess dental plaque, all subjects utilized a fluorescein mouth rinse, and intraoral photographs were taken under black light imaging. For hs-CRP, levels were measured by an independent laboratory using an enzyme linked immunosorbent assay.

Humanized organs in gene-edited animals

Humanized organs in gene-edited animals is one potential way medicine can deal with the demand for transplant organs.


One potential avenue for research and to help solve the organ shortage is to modify animals to be closer matched to humans in order to have organs capable of being used for transplant. This short paper is an interesting primer into the subject and touches upon the technical and ethical concerns involved here.

It is one possible solution to the problem, however, 3D bioprinting increases in sophistication and other methods are also being developed that would render this approach needless. Still this is an interesting insight into regenerative medicine and one possible path research might take.

#LifespanIO #aging #crowdfundthecure

http://www.futuremedicine.com/doi/10.2217/rme-2016-0096

Biocentrism: Where The SOUL Goes After Death [VIDEO]

Now, from the wild side.


Quantum Theory Proves Consciousness Moves To Another Universe After Death. There is an interesting new theory emerging from a scientist long familiar with physics, quantum mechanics and astrophysics. Biocentrism teaches that life and consciousness are fundamental to the universe. It is consciousness that creates the material universe, not the other way around. At least, the new thinking that has given birth to the new theory of biocentrism, which the professor, Dr. Robert Lanza, freely espouses. Lana has been voted the 3rd most important scientist alive by the NY Times. Lanza is an expert in regenerative medicine and scientific director of Advanced Cell Technology Company. Before he has been known for his extensive research which dealt with stem cells, he was also famous for several successful experiments on cloning endangered animal species. Biocentrism—is a concept proposed in 2007 by American doctor of medicine Robert Lanza, a scientist in the fields of regenerative medicine and biology, which sees biology as the central driving science in the universe, and an understanding of the other sciences as reliant on a deeper understanding of biology. Biocentrism states that life and biology are central to being, reality, and the cosmos—consciousness creates the universe rather than the other way around. It asserts that current theories of the physical world do not work, and can never be made to work, until they fully account for life and consciousness. While physics is considered fundamental to the study of the universe, and chemistry fundamental to the study of life, biocentrism claims that scientists will need to place biology before the other sciences to produce a theory of everything.

Scientists may have identified the genes responsible for ageing

Researchers have discovered a link between a protein and aging

A protein found within the powerhouse of a cell could be the key to holding back the march of time, research by scientists at The University of Nottingham has shown and the discovery could offer a new target for drugs that may help to slow the debilitating effects of ageing on our bodies.

Their research, published in the academic journal Aging, could have special significance for combatting age related decline and halting the progression of neurodegenerative conditions such as Alzheimer’s and Parkinson’s Disease.

Houston establishes itself as a pioneer in regenerative medicine

Inside Doris Taylor’s lab at the Texas Heart Institute are ethereal white pig hearts, stripped of their cells and now a blank slate of an organ.

Removing cells from an organ is fairly simple for scientists like Taylor. Rebuilding the organ by injecting stem cells is the tricky part.

But that’s exactly what Taylor hopes to do: grow a human heart by injecting human stem cells into a “decellularized” organ.

First human clinical trial for nicotinamide riboside

(credit: iStock)

In the first controlled clinical trial of nicotinamide riboside (NR), a newly discovered form of Vitamin B3, researchers have shown that the compound is safe for humans and increases levels of a cell metabolite called NAD+ that is critical for cellular energy production and protection against stress and DNA damage.

Levels of NAD+ (first discovered by biochemists in 1906) diminish with age, and it has been suggested that loss of this metabolite may play a role in age-related health decline.

Brexit for Transhumanists: A Parable of Getting What You Wish For

For the past two years, Zoltan Istvan has been campaigning for the US presidency on the Transhumanist Party, a largely one-man show which nevertheless remains faithful to the basic tenets of transhumanism. Now suppose he won. Top of his policy agenda had been to ensure the immortality of all Americans. But even Zoltan realized that this would entail quite big changes in how the state and society function. So, shortly after being elected president, he decides to hold a national referendum on the matter.

The question on the ballot is one that makes the stakes crystal clear: ‘The government shall endeavour to release all Americans from the constraints of mortality’. Zoltan liked this way of putting things because were he to lose to the referendum, which he half-presumed, the opportunity to air publicly the relevant issues would continue to shift naysayers in Congress to increase funding for broadly anti-death research and treatments — a step in the right direction, as far as he’s concerned.

Zoltan also liked the idea that the referendum effectively ‘rotated the political axis’, from left-right to up-down, a turn of phrase he picked up from some philosopher whose name he couldn’t remember. But this also meant that the ensuing campaign, which was fierce, attracted a motley crew of supporters on both sides.

The ‘Remainers’ (as the anti-immortalists call themselves) were composed of a mix of traditional religious believers, environmental activists and hard-headed sceptics who distrust all transcendental hype, whether it comes from religion or science. In other words, those who wanted us to remain in our normal bodies held that our fate either is confined to our current circumstances or requires that we remain in those circumstances in order for something better to happen post mortem. The stakes were so high that even the Pope was called out to argue the case, which of course he was more than happy to do, Obama-style.

On the other hand, the ‘Leavers’ who espouse immortality were an even more mixed bag. Some on the ‘soft’ side of the argument wanted us to remain in our biological bodies, but in a fortified form that makes us forever resistant to foreign agents. Thus, the prospect of reversing the ageing process got sold as an indefinite productivity booster, allowing us to do what we already do but without the constraints imposed by age and death. In contrast, the ‘hard’ side wanted us to leave our biological bodies altogether and enter into the relatively unregulated realm of ‘digital immortality’, which was sold as enabling us to interact with a broader range of agents than we could otherwise do, both on Earth and maybe even in the cosmos. Indeed, various interfaces were being developed that would enable us to exchange data easily with all sorts of non-human beings to mutual benefit. And matters could go much further – even towards a ‘Singularity’, a universal free trade data zone! However, none of this could be brought to fruition unless we first release ourselves from various codes and norms that inhibit their development and use.

It turns out that the Leavers managed to suppress their differences during the campaign and surprisingly eked out a narrow win. But what was President Zoltan to do? Understandably he wanted to keep his options open with regard to how immortality is implemented. So the first thing he did was to appoint a cabinet with a broad church of Leavers on board, and so both Aubrey de Grey and Ray Kurzweil figured prominently. But these guys pulled the implementation of Leave in opposing directions. De Grey wanted to focus on a radical extension of conventional medical research. Indeed, when de Grey first heard that President Zoltan was holding a referendum, he was concerned that ‘immortality’ might mean only the digital immortality favoured by Kurzweil, which de Grey regards as a complete fantasy.

By the time the referendum campaign began, Zoltan had managed to get Congressional approval to increase funding and loosen regulation in ways that enabled various pro-immortality research projects to move forward at an unprecedented pace. However, as the campaign progressed, it became clear that the soft immortalist side was lagging: There appeared to be much greater cellular complexity to the reversal of ageing than de Grey and his colleagues had imagined.

Meanwhile a clever tech entrepreneur, inspired by the economist Robin Hanson, had figured out a way to scan living brains for purposes of uploading them into machines capable of enhancing their computational power indefinitely. These brain emulations (or ‘ems’) are indeed at least in principle immortal, but at the cost of leaving the original human in a state of disorganized mush, which is to say, biologically ‘dead’. Because Zoltan had already de-regulated all transhumanist-related industries, the ‘ems’ end up dominating the market, with large public relations firms emerging to persuade people that they will live better lives by abandoning their biological bodies and uploading into what some liken to Star Trek’s Borg.

After a few generations, Earth had earned a reputation as the most rational death cult in the cosmos.

And they all ‘lived’ happily ever after…

/* */