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Category: life extension – Page 660

MMTP — Major Mouse Testing Program — Interview with Daria Khaltourina — ILA

MMTP Campaign update “Aging is a disease”.

Crowdfunding Campaign: https://www.lifespan.io/campaigns/the-major-mouse-testing-program/

We are testing a combination of compounds which clear out dysfunctional cells in the body, called Senolytics, to see if we can extend maximum lifespan and healthspan in mice. Please subscribe, share, and fund our Lifespan.io campaign today!

MMTP — Major Mouse Testing Program.
http://majormouse.org

Is a project by the International Longevity Alliance.
http://longevityalliance.org

Subscribe: https://www.youtube.com/user/LifespanIO

Continue reading “MMTP — Major Mouse Testing Program — Interview with Daria Khaltourina — ILA” | >

Tratamento com hormônios sexuais recupera células de doenças genéticas graves

Treatment with sex hormones recovers serious genetic diseases cells, this is the first demonstration that the lengthening of telomeres is possible in humans with the use of a medication,” says the researcher.

Estudo demostrou que há como estimular a enzima telomerase por meio de hormônios sexuais, tanto masculinos quanto femininos.

Por — Editorias: Ciências, Ciências Biológicas, Ciências da Saúde.

Is aging inevitable? Not necessarily for sea urchins

Sea urchins are remarkable organisms. They can quickly regrow damaged spines and feet. Some species also live to extraordinary old ages and—even more remarkably—do so with no signs of poor health, such as a decline in regenerative capacity or an increase in age-related mortality. These ocean Methuselahs even reproduce as if they were still youngsters.

MDI Biological Laboratory Associate Professor James A. Coffman, Ph.D., is studying the of sea urchins in hopes that a deeper understanding of the process of regeneration, which governs the regeneration of aging tissues as well as lost or damaged body parts, will lead to a deeper understanding of the aging process in humans, with whom sea urchins share a close genetic relationship.

In a paper recently published in Aging Cell, a leading journal in the field of aging biology, with Andrea G. Bodnar, Ph.D., of the Bermuda Institute of Ocean Studies, the scientists shed new light on the aging process in sea urchins, raising the prospect that the physical decline that typically accompanies aging is not inevitable.

Majority of Americans dislike both Trump and Clinton as interest in third-party spikes online

I’m excited to see I’m the fourth most searched 3rd party presidential candidate. Thanks for your support of a science, longevity, and technology platform as an alternative to the establishment. If this continues a nonreligious transhumanist could end up #4 or #5 in the final elections, and even get enough votes (maybe a million or more) to push the US election one way or the other if it’s close.

So much about the 2016 presidential election is unprecedented. But perhaps nothing is more unusual than the electorate’s level of dissatisfaction with both major parties’ likely nominees.

An NBC News-SurveyMonkey poll released earlier this week found that, while Democratic front-runner Hillary Clinton maintains her lead in a head-to-head match-up with presumptive Republican nominee Donald Trump, neither candidate is popular with the public at large.

Approximately 60 percent of respondents told pollsters that they either “disliked” or “hated” Clinton, while 63 percent felt the same way about Trump.

Pollster Laura Wronski noted that 23 percent of respondents said they disliked or hated both Trump and Clinton.

Gene helps prevent heart attack, stroke; may also block effects of aging

May turn out to be the “fountain-of-youth gene,” say researchers.

An atherosclerotic lesion. Such lesions can rupture and cause heart attacks and strokes. (credit: UVA School of Medicine)

University of Virginia School of Medicine have discovered that a gene called Oct4 — which scientific dogma insists is inactive in adults — actually plays a vital role in preventing ruptured atherosclerotic plaques inside blood vessels, the underlying cause of most heart attacks and strokes.

The researchers found that Oct4 controls the conversion of smooth muscle cells into protective fibrous “caps” inside plaques, making the plaques less likely to rupture. They also discovered that the gene promotes many changes in gene expression that are beneficial in stabilizing the plaques. In addition, the researchers believe it may be possible to develop drugs or other therapeutic agents that target the Oct4 pathway as a way to reduce the incidence of heart attacks or stroke.

Could impact many human diseases, regenerative medicine

The researchers are also currently testing Oct4′s possible role in repairing cellular damage and healing wounds, which would make it useful for regenerative medicine.

Continue reading “Gene helps prevent heart attack, stroke; may also block effects of aging” | >

Researchers identify genes linked to the effects of mood and stress on longevity

The visible impacts of depression and stress that can be seen in a person’s face—and contribute to shorter lives—can also be found in alterations in genetic activity, according to newly published research.

In a series of studies involving both C. elegans worms and human cohorts, researchers from the Indiana University School of Medicine and the Scripps Research Institute have identified a series of genes that may modulate the effects of good or bad mood and response to stress on lifespan. In particular, the research pointed to a gene known as ANK3 as playing a key role in affecting . The research was published May 24, 2016 in the Nature Publishing Group journal Molecular Psychiatry, the top ranked journal in the field of psychiatry.

“We were looking for genes that might be at the interface between mood, stress and longevity”, said Alexander B. Niculescu III, M.D., Ph.D., professor of psychiatry and medical neuroscience at the IU School of Medicine. “We have found a series of genes involved in mood disorders and stress disorders which also seem to be involved in longevity.

Aging Research Internships Available

Are you an avid supporter of aging research and a keen longevity activist?
The Biogerontology Research Foundation is offering select summer internships for talented individuals. You’d join a passionate and supportive team in researching diagnostic, prognostic, and therapeutic strategies; advising a panel of investors in developing a roadmap to promote longevity science and related technologies across the globe.

The advertised positions are 3 month internships, with the possibility of continuing afterwards. Free accommodation will be provided for in London, alongside a negotiable salary.

The Biogerontology Research Foundation is a UK based think tank dedicated to aging research and accelerating its application worldwide.

Apply to: [email protected]

Are you an avid supporter of aging research and a keen longevity activist?

The Biogerontology Research Foundation is offering select summer internships for talented individuals. You €™d join a passionate and supportive team in researching diagnostic, prognostic, and therapeutic strategies; advising a panel of investors in developing a roadmap to promote longevity science and related technologies across the globe.

Senescent Cells, Cancer, and Aging — Dr. Judith Campisi

Dr. Judith Campisi, a professor at the Buck Institute for Research on Aging, focuses her lecture on senescent cells and their role in cancer and aging. She explains how cancer is an age-related disease by describing the many conditions beyond DNA mutations that must generally be met for a malignant tumor to form. Dr. Campisi acknowledges that while cellular senescence is a powerful anti-cancer mechanism and while senescent cells may even play a key role in wound healing, senescent cells can nonetheless cause inflammation in their local environment and actually support the formation of tumors.

Visit www.sens.org/videos to view the rest of our course lecture videos.