My speech at the Augmented World Expo on the future of politcs was covered by the BBC.
I spend time with a man who wants to live forever and thinks a computer may one day run the US.
Category: life extension – Page 656
Ageing breakthrough: Scientists create “hyper-long” telomeres without gene editing
Scientists have successfully created mice with significantly longer telomeres than normal, resulting in a drop in molecular ageing, without using genetic manipulation.
Telomeres, which are found at the end of all animals’ chromosomes, are thought to be vital to ending ageing, as their shortening as we age is a key factor in cellular ageing and the onset of age-related disease. However, when they are lengthened beyond normal levels in mice, they have the precise opposite effect, protecting against ageing and related diseases, and increasing lifespan.
The mice, which are chimeras carrying both regular and “hyper-long” telomeres, were created using a technique based on epigenic changes, where embryonic stem cells are expanded in vitro, prompting changes to telomeres.
Scientists create mice with hyper-long telomeres without altering the genes
The cells with hyper-long telomeres in these mice appear to be perfectly functional. When the tissues were analysed at various moments (0, 1, 6 and 12 months of life), these cells maintained the additional length scale (they shortened over time but at a normal rhythm), accumulated less DNA damage and had a greater capacity to repair any damage. In addition, the animals presented a lower tumour incidence than normal mice.
These results show that pluripotent stem cells that carry hyper-long telomeres can give rise to organisms with telomeres that remain young at the molecular level for longer. According to the authors, this “proof of concept means that it is possible to generate adult tissue with longer telomeres in the absence of genetic modifications”.
The Telomeres and Telomerase Group at the Spanish National Cancer Research Centre (CNIO), in collaboration with the Centre’s Transgenic Mice Core Unit, has succeeded in creating mice in the laboratory with hyper-long telomeres and with reduced molecular ageing, avoiding the use of what to date has been the standard method: genetic manipulation. This new technique based on epigenetic changes that is described today in the pages of Nature Communications, avoids the manipulation of genes in order to delay molecular ageing. The study also underlines the importance of this new strategy in generating embryonic stem cells and iPS cells with long telomeres for use in regenerative medicine.
Telomeres (the protective structures located at the ends of chromosomes) are essential to the stability of our genetic material and to maintain the “youthful state” of our cells and of our bodies. However, telomeres get shorter as we age. Once they reach a critical length, cells enter a state of senescence or die. This is one of the molecular causes of cellular ageing and of the emergence of ageing-related diseases.
On the other hand, when telomeres are extra-long — as achieved for the first time by the CNIO group headed by Maria A. Blasco using the expression of the telomerase gene — they exert a protective role against ageing and ageing-related diseases, thus significantly extending the lives of the mice.
Vitamin Found To Increase Lifespan and Halt Aging In Muscle Tissues
Scientists have long used NAD+ as a powerful anti-aging tool. While trying to find a cure for aging, scientists increased the levels of NAD+ within the mitochondria. The mitochondria responded by increasing their performance and energy, which effectively neutralizes the effects of aging.
Lead researcher Johan Auwerx explained that “this work could have very important implications in the field of regenerative medicine,” adding that it may one day be possible to bypass surgery and repair the body with a dietary supplement.
Specifically, nicotinamide riboside “effectively delayed early- and late-stage disease progression, by robustly inducing mitochondrial biogenesis in skeletal muscle and brown adipose tissue, preventing mitochondrial ultrastructure abnormalities and [mitochondrial DNA] deletion formation.”
The Sad Tragic Truth About Our Relationships
The Search For Immortality … https://www.facebook.com/jasonlsilva/videos/1627219640875648/
What do we do when we know everything — including our love for one another — will pass?
31 responses to “Neverending Sex”
Let’s formulate the task of life extension slightly differently. Something like this…How can we extend sex appeal?
Gyms and beauty salons are in charge of this question now. There is some success, but it’s mostly superficial. Plastic surgery only masks, but doesn’t delay the processes of aging.
Expanding sex appeal is a complex task. Its aspects include both beauty and the activity of the brain. To be sexually attractive we have to be smart and fun. One cannot solve the problem of dementia with makeup.
We have to be in an excellent physical shape to be sexually attractive, but also things should be running smoothly with our hormonal regulation.
The task of extending the period of sex appeal is extremely science-intensive. It is not only the Viagra, but a complex impact on the whole organism. It is obvious that molecular biology is responsible for sex in the modern world.
Transhumanist visionary Zoltan Istvan believes Donald Trump, Hillary Clinton need him to win
Here’s an article on transhumanism in Oregon’s largest paper, The Oregonian: It highlights something I’m trying to create: the impact of a “longevity vote” in the elections to make a difference for the length of people’s lifespans.
Zoltan Istvan is ready to encourage his supporters to vote for either Hillary Clinton or Donald Trump in November — if one of the major-party candidates agrees to put him to work in the White House.
And they’d better take his offer seriously, because he figures he just might be able to tip the election whichever way he wants.
“If we’re getting down to the end, and it’s close, as expected, this could be appealing to a candidate,” Istvan told The Oregonian this week. He believes he could bring a candidate somewhere between 250,000 and a million votes.
If neither Clinton nor Trump takes him up on his proposed deal, he’ll keep those votes for himself. Istvan, a former journalist, is the presidential candidate for the Transhumanist Party, which he created in 2014.
MMTP — Major Mouse Testing Program — Interview with Daria Khaltourina — ILA
MMTP Campaign update “Aging is a disease”.
Crowdfunding Campaign: https://www.lifespan.io/campaigns/the-major-mouse-testing-program/
We are testing a combination of compounds which clear out dysfunctional cells in the body, called Senolytics, to see if we can extend maximum lifespan and healthspan in mice. Please subscribe, share, and fund our Lifespan.io campaign today!
MMTP — Major Mouse Testing Program.
http://majormouse.org
Is a project by the International Longevity Alliance.
http://longevityalliance.org
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