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Category: life extension – Page 638

A new algorithm has been developed that will drastically reduce the time and effort needed to create induced pluripotent stem cells (iPSCs). As a result of this breakthrough, we can expect a dramatic revolution in regenerative medicine in the near future.

What if you could directly reprogram cells to develop into whatever you wished? What if you could take an undifferentiated, incipient cell, full of the unrealized potential to become any one of the many specialized cells in the human body, and nudge it into becoming ocular tissue, or neural cells, even a new heart to replace an old or damaged one?

This is the promise afforded by Mogrify, the result of the application of computational and mathematical science to the problems of medicine and biology. It was developed by an international collaboration of researchers from the Duke-NUS Medical School in Singapore, the University of Bristol in the United Kingdom, Monash University in Australia, and RIKEN in Japan. The new research was published online in the journal Nature Genetics.

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Stanford used modified messenger RNA to extend the telomeres so the whole process if it translates effectively into humans — and the evidence is suggesting it will — would be pretty straightforward especially when you consider the degree of extension which is 1000 nucleotides and the fact that the telomerase which lengthens the telomeres is only active in the body for 48 hours which means there is no significant risk of cancer due to the limited time during which proliferation of the cells could take place.

It’s true that Lobsters defy the normal aging process which in humans increases the risk of heart disease, stroke, cancer, Alzheimer’s and diabetes in humans but not only that they actually become stronger and bigger with age each time they shed their shell whereas humans and other mammals are completely the opposite suffering muscle loss, stiffness and elevated risk of fractures etc. Lobsters just keep growing and can grow to a colossal size over the years there is information on a 95 year old 23 pounder (10.5kg) here http://www.cbsnews.com/news/95-year-old-lobster-featured-at-…estaurant/

Normally a lobster dies because it is eaten by a predator I.e us!, suffers an injury or gets a disease. we know the reason they remain fit and strong and it lies in their use of telomerase to protect their DNA and prevent their telomeres shortening and as a result protecting their cells from dying they also have a vast supply of stem cells which can turn into any into any type body of tissue and this will be one of our main tools for biomedical repairs in the future along with telomere lengthening as explained below because if we can extend our telomeres we will also hold one of the keys to life extension.

Based on current research it is technically possible and highly probable work on telomere lengthening at Stanford university will translate into humans giving us the health benefits currently confined to lobsters and the hydra. The primary concern with the lengthening of telomeres used to lie in the theoretically elevated risk of cancer but this problem does not apply based on the current research which you can see on the Stanford University website here https://med.stanford.edu/news/all-news/2015/01/telomere-exte…cells.html as a researcher in aging I consider this research and some supporting and complementary research which has taken place at Harvard coupled with a additional research relating to a compounds that is related to Rapamycin tends to indicate that we are finally making significant progress in addressing the diseases of aging. Interestingly shortening of telomeres was until recently perceived by many as being a result of aging and not causal but the research at Stanford clearly repudiates this and suggests that Dr Bill Andrews the leading researcher into telomeres was correct all the way along.

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The real opportunities of our future is when we truly integrate technology and genetics/ healthcare together to the point that technology benefits from learning and evolving from what we do in genetics/ healthcare; and genetics/ healthcare truly evolve through technology discoveries and evolution. Does this sound like singularity? Yes; however, this is when we truly see some amazing advancements in both fields. And, several investors (even in Silicon Valley) are investing in technology that is positioned to focus on evolving technology through healthcare.

Scientists have been quietly working for decades to crack the genetic codes that allow humans to live forever, or at least significantly longer.

And judging by the bits of information on this research that is beginning to leak into the mainstream of human discourse, the idea may no longer be far-fetched.

Stuart Kim, a genetics professor at Stanford University, recently appeared on Fox Business News speaking about his work in the field of “gene therapy.”

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Life extension story in Financial Times:

People have long dreamt of extending the human lifespan from the biblical “three score years and 10” (70) to reach Methuselah’s 969 and beyond.

Demographic statistics show remarkable progress in fending off death, at least in the developed world. In reality, average life expectancy in biblical times was not 70 but about 35 years. In Britain this rose to about 50 in 1900, 76 in 1990 and 82 today.

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Canada’s federal government believes that ‘regenerative medicine is the future,’ and they’re ready to put money behind this statement.

Stem cells are remarkable. They have the ability to grow into a plethora of different kinds of cells. As the National Institute of Health notes, they are capable of “dividing essentially without limit to replenish other cells as long as the person or animal is still alive.” And it is precisely this ability to grow and develop into different cell types that makes stem cells so useful in the fight again a host of diseases and ailments.

Now, Canada’s newly appointed Prime Minister, Justin Trudeau, has just announced that the federal government is set to put in $20 million towards the development of the Centre for Commercialization of Regenerative Medicine. The move is set to support the establishment of a stem-cell therapy development facility in Toronto.

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Was hit by a car when I was younger and broke my leg. This would have been better then a metal rod. Fascinating.

A team of researchers from the University of Michigan has developed a new technique to aid bone repair, using polymer nano-shells to deliver microRNA molecules. The method could one day have a big impact on regenerative medicine, directing cells already present at injury sites to aid healing.

The new study builds on previous research conducted back in 2011, where nanofiber microspheres were used to carry cells to injury sites to help the wounding process. The new work uses the same idea, but rather than transporting foreign cells, focuses on making better use of the cells already at the wound site.

The team developed tiny polymer spheres that are able to easily breach cell walls, carrying microRNA molecules to cells at bone wound sites. The spheres are designed to protect the molecules during transit, degrading once in place in cells at the site of the wound.

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