Lifeboat Foundation: Safeguarding Humanity
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Category: life extension – Page 584

I was under the impression that human trials were already underway, but this says they will start in 6 months.

UNSW researchers have made a discovery that could lead to a revolutionary drug that actually reverses ageing, improves DNA repair and could even help NASA get its astronauts to Mars.

In a paper published in Science today, the team identifies a critical step in the molecular process that allows cells to repair damaged DNA.

Their experiments in mice suggest a treatment is possible for DNA damage from ageing and radiation. It is so promising it has attracted the attention of NASA, which believes the treatment can help its Mars mission.

Continue reading “Scientists unveil a giant leap for anti-aging” | >

In a world without ageing, our idea of family will likely change—for the better.

So it would, and I’m looking forward to it.

As things stand, this is what happens to a human family in a nutshell. Two people start dating. If things go well, they may want to live together and have kids. The kids grow up and do the same, eventually, and the original parents become grandparents, generally around the time they start being elderly. Unfortunately, this means they are less and less able to take care of themselves (let alone their grandchildren), and thus are more of a burden than a helping hand. (Talk to people who are around 60 and have kids, and you’ll find out their worst concern is being a burden to their families the moment they’re no longer able to take care of themselves.)

Grandparents eventually die. Repeat the process for enough generations, and eventually the members of the original family will all have died—the family is dismantled. Maybe other families originated from it, but it is irrelevant. The people are what matters to us, not their genes. Genes will be passed on, but all the people in the process will die, and become just a carrier for the genes. Looks like we really should have read the fine print before signing up for life, eh?

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A popular science article discussing the imminent arrival of senescent cell removing therapies.

Imagine a world where you could take just a single pill for the treatment or prevention of several age-related diseases. Although still in the realms of science fiction, accumulating scientific data now suggests that despite their biological differences a variety of these diseases share a common cause: senescent cells. This has led scientists to find drugs that can destroy these cells.

When cells become damaged, they either self-destruct (apoptosis) or they lose their ability to grow and remain stuck within the body. These are the non-growing senescent cells that no longer carry out their tasks properly. They spew out chemicals that cause damage to cells nearby, sometimes turning them into “zombies” – hence why they are sometimes referred to as “zombie cells”. Eventually, the damage builds up so much that the function of bodily organs and tissues, such as skin and muscle, becomes impaired. At this point, we identify the changes as disease.

Depending on where these senescent cells gather within the body will determine which disease will develop. Senescent cells have now been shown to be linked to several diseases, including cardiovascular disease, type 2 diabetes, osteoarthritis and cancer.

Continue reading “Killing ‘zombie’ cells to improve health in old age” | >

A nice long feature on #transhumanism in The Irish Times, one of Ireland’s largest papers. It focuses on the book To Be A Machine: http://www.irishtimes.com/culture/books/who-wants-to-live-fo…-1.3010223 Separately, The New York Times ran a rather somber view of a few transhumanism books, two of the books (The Body Builders & To Be a Machine) which I’m quoted in: https://www.nytimes.com/2017/03/16/books/review/gene-machine.…html?_r=0

Mark O’Connell has spent several years talking to people who want to live through robots and technology, and he admits it stems from his own obsession with death.

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And today a clear lesson in why jumping the gun and not using appropriate engineering safety in regenerative medicine is reckless and dangerous. The steady and scientific path is always the best way when health is on the line. The current system needs streamlining for sure and projects like Lifespan.io are helping to create a progressive environment but ensuring appropriate safety is observed. We must be careful in healthcare and this story reminds us why.

Three women suffered severe eye damage at a Florida clinic, exposing gaps in protections for people seeking unproven treatments.

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