Lifeboat Foundation

One of the highlights this year was the SENS RB2016 conference which was live streamed and is available to watch right now if you missed if the first time around. Three days of exciting biotechnology smile

Although the event itself was invitation-only, our free live stream allowed viewers from 62 countries to enjoy a broad range of presentations on the emerging rejuvenation biotechnology industry and SRF’s critical role in driving forward the clinical translation of truly effective medicine for age-related disease.

Don’t worry if you missed it, though — the streamed videos remain available here!

Continue reading “Rejuvenation Biotechnology 2016” »

Mitochondria — the structures within cells mostly known for converting nutrients into usable energy — may play a larger and more direct role in the aging process than previously thought, according to USC Leonard Davis School of Gerontology Assistant Professor David Lee.

In addition to powering cells, mitochondria serve important roles in coordinating metabolism, Lee said. And evidence has shown that mitochondria — which have their own smaller genome separate from the larger collection of genes in a cell’s nucleus — lose function and accrue DNA damage during the aging process, reflecting a role in aging.

In trying to determine how the mitochondria are involved in aging, many researchers have studied the signals sent from the nucleus to the mitochondria and how they change with age. However, Lee theorizes that communication between the cell’s powerhouse and its control center may be taking place in both directions, with signaling molecules originally coded in the mitochondrial DNA regulating the nucleus and causing changes that affect key cellular factors of aging, such as metabolism.

Hey folks, great news! The Patrons Challenge is going really well and we have already passed the halfway mark for new Patrons which is superb. Thanks to Reason and Josh Triplett who are doubling all new pledges made this year. So if you are interested in being a Patron this is a great time to join us.

Our Winter fundraiser has also reached almost 25k and is going great guns. The more we can raise the more research we can do and as this year has shown, some truly great results are starting to arrive for the SENS approach to treating age-related diseases.

Our guest for this show is Aubrey de Grey, Ph.D., and he refuses to accept aging as something we can not change. Aubrey is a Biomedical Gerontologist and Chief Scientific Officer of The SENS Research Foundation. I talk more about his background and the SENS Foundation in the interview. Aubrey has put forth a model for aging based on seven types of damage that occur as a product of aging. We discuss this model and the techniques the possibly address each category of damage. This interview is longer than the other thus far but it had me gripped the entire time so enjoy!

MEDIA
Soundcloud :: https://soundcloud.com/humanOSRadio

Continue reading “Aubrey de Grey on living to 150 or beyond using biotechnology” »

While the social media company cooperated with the research, it tracks other findings that social ties are linked to longevity.

“Calorie restriction has been known to extend lifespan for a long time.” said Dr. Kennedy. “The DNA damage response is linked to aging as well. LOS1 may be connecting these different processes.”

A number of the age-extending genes the team identified are also found in C. elegans roundworms, indicating these mechanisms are conserved in higher organisms. In fact, many of the anti-aging pathways associated with yeast genes are maintained all the way to humans.

The research produced another positive result: exposing emerging scientists to advanced lab techniques, many for the first time.

SRF Summer Scholars Program opens December 1st!

The SRF Summer Scholars Program offers undergraduate students the opportunity to conduct biomedical research to combat diseases of aging, such as cancer, Alzheimer’s, and Parkinson’s Disease. Under the guidance of a scientific mentor, each Summer Scholar is responsible for his or her own research project in such areas as genetic engineering and stem cell research. The Summer Scholars Program emphasizes development of both laboratory and communication skills to develop well-rounded future scientists, healthcare professionals, and policy makers. Students participating in the program will hone their writing skills via periodic reports, which are designed to emulate text scientists commonly must produce. At the end of the summer, students will have the opportunity to put all of their newly developed communication skills into practice at a student symposium.

Continue reading “2017 SRF Summer Scholars Program” »

Aubrey de Grey in the British paper “The Express”. Sadly not given the his correct Dr. title and also misquoted once again as saying people will live forever.

HUMANS could potentially live forever, according to a a leading researcher on the subject.

2013 saw the release of one of the most important papers in aging research and one that saw renewed interest and support for the concept of SENS.

Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. Aging research has experienced an unprecedented advance over recent years, particularly with the discovery that the rate of aging is controlled, at least to some extent, by genetic pathways and biochemical processes conserved in evolution. This Review enumerates nine tentative hallmarks that represent common denominators of aging in different organisms, with special emphasis on mammalian aging. These hallmarks are: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. A major challenge is to dissect the interconnectedness between the candidate hallmarks and their relative contributions to aging, with the final goal of identifying pharmaceutical targets to improve human health during aging, with minimal side effects.