Lifeboat Foundation: Safeguarding Humanity
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Category: life extension – Page 477

I know 100 leaders in longevity area. All of them will be invited to the Longevity Impact Forum, to create sort of Alibaba of longevity. We can beat government agencies and big companies because of our spirit!

“Underdog” entrepreneur Jack Ma is now famous for his record setting IPO when he took his e-commerce company, Alibaba, public. But not many people know he started Alibaba in his one-room apartment with 17 friends. Watch where all the magic of Alibaba started and be sure to check out Jack Ma’s amazing life.

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David Gobel was the first to put forward the concept of longevity escape velocity, or LEV. How far are we from LEV, assuming the current pace of research and no serious showstoppers?

Twelve years, or 2030, is David’s best guess based on what is known today.

David Gobel cofounded the Methuselah Foundation with Aubrey de Grey and continues to run the Methuselah Foundation today.

Methuselah Foundation has given millions of dollars to regenerative medicine research, backing ventures such as Organovo, Oisin Biotechnologies, and SENS Research Foundation.

Continue reading “Methuselah Foundation Cofounder thinks Longevity Escape Velocity could be here by 2030” | >

What does it feel like when you know your doctor can’t really help you?

Some time ago, I noticed a stock photo of an old lady seeing her geriatrician, who was a much younger woman. Nothing special was happening in the picture, which showed just two people talking; however, it made me wonder what it must feel like to be an elderly person consulting a geriatrician.

One initial assumption could be that it isn’t much different than seeing a GP, but that seems unlikely. If you are seeing a GP, the odds are your disease or ailment is not debilitating, let alone life-threatening. Whatever it might be, you went to see your doctor knowing that, most likely, he or she would be able to cure you; especially if you are young, it’s probable that just taking a medicine for some time, or doing physical therapy, will make you better. You know that you will recover, and the discomfort or the suffering you’re going through is destined to go away. You will get back to your life as it used to be, healthy as ever.

Things are rather different when you are seeing a geriatrician. A geriatrician is a specialist who takes care of the needs of elderly patients, an activity that can be summarized as ensuring the highest possible life quality of a patient in spite of his or her failing body, which becomes increasingly less resilient and less able to respond to treatment with the passing of time. Existing drugs and exercise programs, for example, can ameliorate the symptoms that an elderly person experiences and improve his or her life quality, but the vast majority of age-related diseases simply cannot be cured right now.

Continue reading “From Within Your Own Failing Shell” | >

Lowell interviews the always fascinating Professor George Church in this new podcast series about aging research. Lifespan.io will be appearing on the show soon too so watch this space bigsmile

Harvard & MIT Professor, author of Regenesis, methods for 1st genome sequence (1994) & 10M-fold improvements (NGS, nanopore), genome editing, writing and recording. In this episode, we get to talk about Genghis Khan, Woolly Mammoth, storing data in DNA, advice for people getting started, and more all in under one hour!

George is one of the most interesting and down to earth people you’ll read about (might be from the future or an alien, but cannot confirm). He is always working to make all of our lives better. Anytime you are looking for inspiration, do what I do, and learn about what he and his team are working on. I always feel like I can do anything after reading or listening to the current things he is working on. I hope to one day contribute like he does! As a side note: I am working on something that was inspired from our discussion, so we shall see how that goes. If anyone is inspired after listening to him talk, please email me and let me know. We can start a fan group around George and scientists in general. Scientists are the unsung superheros of our society! Also, scroll down to the bottom to see the breadth of his work. I felt like it should be put here in it’s entirety. Hyperlinked show notes will go up tonight for this episode and the previous ones that are lacking them!

“George Church, professor at Harvard & MIT, co-author of 480 papers, 130 patent publications & the book ”Regenesis”, developed methods used for the first genome sequence (1994) & million-fold cost reductions since (via NGS and nanopores), plus barcoding, DNA assembly from chips, genome editing, writing & recoding. He co-initiated the BRAIN Initiative (2011) & Genome Projects (1984, 2005) to provide & interpret the world’s only open-access personal precision medicine datasets.

Continue reading “Dr. George Church and I Discuss the Woolly Mammoth, Human Aging, DNA Data Storage, and Other Amazing Projects Coming Out of His Lab with Advice for People Getting Started” | >

Today, we want to point out a new publication that dives into the world of senolytics, which are drugs or therapies that seek and destroy harmful non-dividing cells that resist the programmed cell death known as apoptosis.

These cells linger in the body, and, as we age, more and more of them accumulate and contribute to the chronic age-related inflammation known as “inflammaging” while reducing tissue regeneration and repair and contributing to the development of various age-related diseases.

One approach to dealing with these problem cells is to tip them over the edge and cause them to self-destruct, thus removing them and the inflammation they cause. A new class of drugs known as senolytics was discovered a few years ago, and the interest in developing them to potentially combat age-related diseases has been growing rapidly.

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An in depth print cover story out on life extension by Forbes Africa—probably destined to become one of the main go-to articles for people on the continent seeking info on the topic. Myself, Aubrey de Grey, and others are featured in it. Excited to see #Africa join the race to overcome death and disease:

Science is pumping in billions searching for solutions that will help humans live longer – and better – and one day even indefinitely.

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Los Angeles County officials launched a program Wednesday to help locate people with autism, Alzheimer’s disease or dementia who may wander off and go missing.

The program, called L.A. Found, will make use of bracelets that can be tracked through radio frequency by sheriff’s deputies. It will also create a new office, housed within the department of Workforce Development, Aging and Community Services, to coordinate a countywide response when somebody goes missing.

“If you get lost, we will help find you,” county Supervisor Janice Hahn, who championed the initiative, said at a news conference.

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An interview with Methuselah Foundation’s founder David Gobel.

David Gobel is an inventor, philanthropist, futurist, and passionate rejuvenation advocate and supporter; he’s known for co-founding Methuselah Foundation with Dr. Aubrey de Grey and for proposing the intriguing concept of “longevity escape velocity”, but his achievements and successes extend far beyond that. David has kindly granted LEAF a most interesting and detailed interview.

If you’re not familiar with the Methuselah Foundation, it is possibly the oldest organization active in the field of rejuvenation advocacy and support; it also works as an incubator for startups working in rejuvenation research and has helped kickstart many of the projects we talk so much about on our website. If you like, you can find more information on Methuselah Foundation in our older article.

We hope you enjoy Dave’s replies as much as we did!

Continue reading “An Interview With David Gobel” | >

Science is advancing rapidly, and the field of aging research is no exception. Our understanding of aging has grown a great deal in the last decade, and we are now reaching the point at which the first therapies that target aging are starting to arrive. Unlike the snake oil of previous years, some of these might actually work; today, we are going to have a look at NAD+ repletion, one such promising therapy.

In the near term, nicotinamide adenine dinucleotide (NAD+) is showing potential for addressing some of the aging processes. NAD+ levels decline significantly during aging in both humans and animals, and studies on old mice have shown that restoring NAD+ levels causes them to look and act like younger mice while increasing their lifespan.

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As technology advances, prospects for increasing the human life span are seemingly everywhere.

But is there a limit to how long humans can live? According to a new study, published today (June 28) in the journal Science, the answer to that question is no. What’s more, the researchers argue that after age 105, the risk of dying each year remains the same.

In 1825, British actuary Benjamin Gompertz proposed that the risk of dying exponentially increases by age, such that a person at age 70 would be at a much higher risk of dying than a 30-year-old. [Extending Life: 7 Ways to Live Past 100].

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