It has recently been suggested that humans could live to 150 by 2020 simply by taking a certain supplement.
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Category: life extension – Page 476
Here in beautiful Basel, Switzerland we open the section Aging and Drug Discovery, actually an intersection of AI, longevity and drug discovery in the Innovation Forums of Basel Life Conference 2018. Dr Alex Zhavoronkov (InSilico Medicine) and Dr Morten Scheibye-Knudsen (University Copenhagen) welcomed us. Dr Jay Olshansky (University of Illinois at Chicago) gave the first lecture. Some examples for age face recognition were shown, emphasising the importance of wrinkles from smoking or others and suggesting that looking younger means living longer! After the wonderful lecture I immediately went to correct my make-up!
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Β-hydroxybutyrate seems to prevent senescence of vascular tissue.
According to a study by Georgia State University scientists, a molecule called β-hydroxybutyrate has anti-aging effects on the vascular system; more specifically, the molecule appears to prevent senescence of vascular cells by promoting cellular quiescence instead [1].
Study abstract
β-hydroxybutyrate (β-HB) elevation during fasting or caloric restriction is believed to induce anti-aging effects and alleviate aging-related neurodegeneration. However, whether β-HB alters the senescence pathway in vascular cells remains unknown. Here we report that β-HB promotes vascular cell quiescence, which significantly inhibits both stress-induced premature senescence and replicative senescence through p53-independent mechanisms. Further, we identify heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) as a direct binding target of β-HB binding to hnRNP A1 markedly enhances hnRNP A1 binding with Octamer-binding transcriptional factor Oct4 mRNA, which stabilizes Oct4 mRNA and Oct4 expression. Oct4 increases Lamin B1, a key factor against DNA damage-induced senescence. Finally, fasting and intraperitoneal injection of β-HB upregulate Oct4 and Lamin B1 in both vascular smooth muscle and endothelial cells in mice in vivo.
https://paper.li/e-1437691924#/
Descartes once described the human body as a “fleshy machine” and today’s transhumanists would likely agree.
Philosopher Nick Bostrom writes that as we seek to peer farther into posthumanity our ability to concretely imagine what it might be like trails offend that the very essence of posthumanity is to be able to have thoughts and experiences that we cannot readily think or experience with our current capacities.
Today’s advances in science and technology will profoundly change what we understand as human. According to transhumanist philosophy humanity until this point has been a story of development for the survival and reproduction, but today thanks to advances in science we are entering a new phase where human beings are masters of their destiny. Therefore the Transhumanist movement envisions a future full of possibilities by broadening our potential as species by overcoming aging, cognitive shortcomings, involuntary suffering, and our confinement to planet Earth.
ATLANTA—A molecule produced during fasting or calorie restriction has anti-aging effects on the vascular system, which could reduce the occurrence and severity of human diseases related to blood vessels, such as cardiovascular disease, according to a study led by Georgia State University.
“As people become older, they are more susceptible to disease, like cancer, cardiovascular disease and Alzheimer’s disease,” said Dr. Ming-Hui Zou, senior author of the study, director of the Center for Molecular and Translational Medicine at Georgia State and a Georgia Research Alliance Eminent Scholar in Molecular Medicine. “Age is the most important so-called risk factor for human disease. How to actually delay aging is a major pathway to reducing the incident and severity of human disease.
”The most important part of aging is vascular aging. When people become older, the vessels that supply different organs are the most sensitive and more subject to aging damage, so studying vascular aging is very important. This study is focused on vascular aging, and in old age, what kind of changes happen and how to prevent vascular aging.”
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From the perspective of critics, there are many reasons to be concerned about the rise of artificial intelligence.
Billionaire inventor Elon Musk — perhaps the world’s most vocal AI antagonist — has warned that the technology could become “an immortal dictator from which we would never escape.”
Several years before his death, Stephen Hawking, the renowned theoretical physicist, said artificial intelligence could bypass biological evolution, leaving humans unable to compete.
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Today, we are going to take a look at the topic of NAD+, its precursor, nicotinamide mononucleotide, and the debate surrounding the ability of these molecules to pass through the cell membrane.
NAD+ is critical for cellular function
Nicotinamide adenine dinucleotide (NAD+) is a redox cofactor, but it is also a critical signaling molecule that regulates cell function and survival in response to environmental changes such as nutrient intake and cellular damage. Age-related changes to the level of NAD+ in the cell impacts mitochondrial function, nutrient sensing and metabolism, redox reactions, circadian rhythm, immune and inflammatory responses, DNA repair, cell division, protein-to-protein signaling, chromatin, and epigenetics.
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An interesting article in Forbes on GDF11, anti-aging drugs and companies:
For an example of how hard it is to develop an anti-aging medicine, check this out. It’s some of the coolest and creepiest science to have been published in major academic journals. But is it ready to form the basis of a pharmaceutical company?
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