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Dr. Sandra Kaufmann
The Author of the book, The Kaufmann Protocol: Why we age and how to stop it.
Category: life extension – Page 425
The colorful Clownfish lives longer than 20 years in the aquarium. Researchers of the Scuola Normale Superiore in Pisa, Italy, in collaboration with the Leibniz Institute on Aging (FLI) in Jena, Germany, have investigated the genetics behind the longevity of clownfish. By sequencing the genome and comparing the sequences with other species, they were able to show, that the secret of this longevity lies in the mitochondria and lysosomes of the clownfish. Because it is uncomplicated to keep and breed clownfish, they represent an interesting new animal model for research on longevity. The results are now published in the journal BMC Evolutionary Biology.
Clownfish, famous because of the Disney movie “Finding Nemo,” are a bright orange-white-black colored fish with three vertical stripes, which occur in the western Pacific and Indian Oceans. Clownfish live in symbiotic relationship with sea anemone. They are reliant on sea anemone for shelter in their natural habitat, which offer protection for the fish with its tentacles. The Clownfish’s mucus protection prevents it from being stung by the tentacles of the sea anemone. Thanks to this survival strategy, clownfish have a lower mortality rate than other fishes and can grow quite old. Until now there was not much known about the lifespan of this interesting sea dweller.
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Sirtuins have long been implicated in playing a role in the longevity of various species, including our own, and researchers at the University of Rochester have now discovered more supporting evidence that they do.
What are sirtuins?
Sirtuins are a family of proteins that facilitate cellular function and have long been known to play a role in aging. In particular, they are responsible for functions such as gene expression and are involved in DNA repair. It has long been understood that sirtuins played a role in aging, but the key factor in how well they function is the presence of nicotinamide adenine dinucleotide (NAD+), a coenzyme found in all living cells. NAD+ biology is central to deregulated nutrient sensing and a reason why we age, and sirtuins play a key role in this biology.
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Keith Comito, interviewed by Adam Ford at the Undoing Aging 2019 conference in Berlin, discusses why solving the diseases of old age is a powerful cause.
How can solving aging reduce suffering? What are some common objections to the ideas of solving aging? How does Anti-Aging stack up against other cause…
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AI Overlords
Musk has repeatedly warned of evil AI overlords in the past, saying that AI could become “an immortal dictator from which we could never escape” in a 2018 documentary called “Do You Trust This Computer?”
Most of what Neuralink is working on, including any plans for a brain computer interface, are still tightly under wraps. In one tantalizing clue, Bloomberg recently reported on a still unpublished academic paper by five authors who have been employed by or associated with Neuralink — though it’s unclear whether Musk’s tweet referred to their work.
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Mesenchymal stem cells (MSCs) have been a topic of great interest in the last decade or so due to their ability to improve tissue regeneration merely by their presence and the secreted signals they give out.
Adult MSCs have traditionally been used for regenerative medicine with hit-and-miss results, depending on the quality and age of the harvested MSCs. It has been discovered in recent years that the efficacy of these cells greatly depends on how damaged by aging they are, which explains why MSC therapy sometimes works very well in one person but not so much in another.
However, what about aged cells that are reprogrammed back to pluripotency then guided into becoming mesenchymal stem cells through cellular reprogramming?
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Earlier this year, we launched a new webinar series where our monthly patrons, the Lifespan Heroes, are given the opportunity to join live discussion panels with the researchers who are working on solving aging.
Our April 8th, 2019 episode saw Dr. Mike Lustgarten, Dr. Amy Proal, and Dr. Cosmo Mielke join hosts Dr. Oliver Medvedik and Steve Hill for a discussion about the microbiome and how it relates to aging.
The webinar discusses gut flora and the pro-aging effects of immune system burden, the link between bacterial burden and inflammation, and exercise and nutrition. There was also plenty of discussion about the immediately available practical measures that can improve the gut microbiome and thus control weight and promote health.
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