A recent study suggests that circulating glucuronic acid may be a useful predictor of both lifespan and healthspan in humans and mice.
What is glucuronic acid?
Glucuronic acid is a metabolite of glucose and is critical for the detoxification of xenobiotic substances. These are compounds that are not naturally produced, should not normally be in the body, or are present in higher concentrations than normal.
The complex interplay of various processes and mechanisms that contribute to aging means it’s unlikely we’ll discover a single “magic bullet” to prevent age-related diseases. But new research led by University College London and the Max Planck Institute for Biology and Ageing is potentially as close as anything we’ve seen. The scientists have been able to extend the lifespan of fruit flies by 48 percent using a triple drug combination made up of drugs already used in people.
“As life expectancies increase, we are also seeing an increase of age-related diseases so there is an urgent need to find ways to improve health in old age,” says study co-lead author, Dr Jorge Castillo-Quan. “Here, by studying fruit flies which age much more rapidly than people, we have found that a combination drug treatment targeting different cellular processes may be an effective way to slow down the aging process.”
The three drugs making up the combo include lithium, which is used as a mood stabilizer, trametinib, a cancer drug that inhibits MEK1 and MEK2 enzymes, and rapamycin, an immune system regulator produced by bacteria that was first found in a soil sample from Easter Island and has been found to improve learning and memory in mice.
Sajad Zalzala wants to enable off-label uses of common drugs, like Metformin, to slow aging.
Ira Pastor, ideaXme longevity and aging ambassador and founder of Bioquark, interviews Ambassador Juan José Gómez Camacho, Mexico’s current Ambassador to Canada, and for the last 3 years, Mexico’s Permanent Representative of the United Nations in New York City.
Ira Pastor Comments:
Today, we are going to talk about a fascinating series of topics related to global population health, and we will start by citing some staggering data.
The World Health Organization (WHO) estimates that there are around 1 billion migrants in the world today. 258 million of them are international migrants and 763 million are internal migrants, that’s one in seven of the world’s population.
68 million of the world’s internal and international migrants are forcibly displaced. This rapid increase of population movement has important public health implications, and therefore requires an adequate response from the health sector as many refugees and migrants often lack access to health services and financial protection for health.
Additionally, although we are only 20 years into the 21st century, it is a century that has already been marked by many major epidemics. Old diseases, such as cholera, plague and yellow fever, have all made a return, and many new ones have emerged including SARS, pandemic influenza, MERS, Ebola and Zika.
Steven Gundry, MD, author of The Longevity Paradox: How to Die Young at a Ripe Old Age, explains how he boosted patients’ lifespan and healthspan by combining conventional medicine with nutritional therapy.
Researchers are working to get to the bottom of longevity, unlocking the secrets to extending our lifespans well into our 100s… and beyond.
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Harvard Professor David Sinclair thinks longevity, or extending our lifespan, is the “greatest unsolved problem in biology.”
The global life expectancy is currently hovering somewhere around 72 years old and women typically live longer than men and the age tends to be higher in developed countries and lower in impoverished nations.
Some experts argue that the tools we currently have when it comes to extending our lifespans are as simple as diet and exercise, but a healthy diet is only going to get you so far. So scientists are seeking out clues in the natural world that could help us side step growing old, some scientists even think that many of the ailments we refer to as diseases could be thought of as the symptoms of aging.
So, in addition to improving our nutrition, sleep, social life, access to health care, and so on, what else can we do to increase our chances of immortality?
Find out more on this episode of How Close Are We?
My mission is to drastically improve your life by helping you break bad habits, build and keep new healthy habits to make you the best version of yourself. I read the books and do all the research and share my findings with you!
This video is “Day 1” of RAADfest 2019 in Las Vegas. I discuss various products, companies & topics that are on display at RAADfest. I will do my best at RAADfest to interview longevity experts like James Strole, Bernadeane, Liz Parrish, Dr. Aubrey de Grey, Dr. Bill Andrews, Dr. Ed Park, Dr. Duncan Ross, Ben Goertzel, Bill Faloon and hopefully many more. I’ll bring you all the major updates from RAADfest!
I’ll be sharing daily RAADfest Roundups this week on my YouTube channel.
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At the Ending Age-Related Diseases 2019 Conference in New York City, we had the opportunity to interview Dr. Justin Rebo from the drug discovery biotech company BioAge.
BioAge is developing a drug discovery platform that uses machine learning and artificial intelligence to discover targets that have the potential to promote healthy lifespan (healthspan) by slowing down aging and the ill health that it brings.
As the vice president of in-vivo biology at BioAge, Dr. Rebo leads the company’s internal in-vivo platform to find and assess the viability of new druggable targets for aging diseases and biomedical regeneration. With considerable business as well as academic experience in the aging field under his belt, Justin joined the BioAge team in 2018.
Posted in biotech/medical, life extension
A year old, and this video is titled with the “I-word”. But a very interesting talk.
It’s not every day that I get to post a video where I feel like I’m involved with something that may seriously improve and extend lives. I’m so grateful that somehow, I was brought into this process.
The ForbiddenKnowledgeTV newsletter and website attract a large number of physicians and health-practitioner subscribers and it’s been a real joy to make friends with the doctors on my list over the years. One leading physician who first contacted me, way back in August 2011 was Dr. Ron Klatz, Founder-President of the American Academy of Anti-Aging and Regenerative Medicine (A4M).
Last week, he asked me to edit this video of the first round table discussion of the American Association of Stem Cell Physicians, which had been live-streamed on August 11th and which he’d helped to moderate. It was shot completely unstaged and it was very rough-and-tumble and it needed a little cleaning-up. I said sure, without fully realizing what a treat I was in for, with this incredibly dynamic and inspiring group of scientists and physicians; who don’t normally speak to each other – let alone on camera – in a totally live, unscripted setting!
In 1996, Dr. Klatz and the A4M predicted that medical advancements were on pace to achieve life expectancies of 120 years or more, or what they call “Practical Immortality” by 2029. With the latest developments in stem cell technology and nutritional medicine, among others, this prediction is well on track.
