Lifeboat Foundation

In this podcast, Aubrey de Grey, Ph.D., and the Chief Science Officer/Co-founder of SENS Research Foundation discusses his fascination with aging and his ongoing efforts to change the way we think about, and treat, age-related conditions. Dr. de Grey is a biomedical gerontologist and the innovative developer of the SENS platform. He is a Fellow of the Gerontological Society of America and the American Aging Association. He received a Ph.D. in Biology from the prestigious University of Cambridge. Dr. de Grey states that aging is the greatest medical problem we face as it causes the most suffering. He discusses the various excuses that are given as reason to simply disregard aging as a field in need of greater research, from the standard, ‘everything ages, just accept it,’ to the more philosophical—‘death, by its existence, gives meaning to life,’ and the social excuse—‘treating aging in a new way would only create new problems that could be much worse.’ But according to Dr. de Gray, not a single excuse holds up, all fall to the slightest scrutiny when really considered. Dr. de Grey explains that in order to design and implement therapies that will prevent the health problems of an aging population, we need to learn from what has already been proven and acknowledged in the past. SENS Research Foundation seeks to develop and promote access to innovative new therapies that can cure or possibly even prevent the diseases and difficult, troubling disabilities of aging by repairing built-up damage in our bodies. Wrapping up, Dr. de Grey explains cell therapy and damage, loss of cells, and the processes needed to bring about the repair. And the doctor goes into detail regarding the injection of stem cells to repair the damage, replace lost cells, etc.

Urolithin A, a metabolite of biomolecules found in pomegranates and other fruits, could help slow certain aging processes. EPFL spin-off Amazentis, in conjunction with EPFL and the Swiss Institute of Bioinformatics, has published a paper Metabolism outlining the results of their clinical trial.

It is a fact of life that skeletal muscles begin to lose strength and mass once a person reaches the age of 50. A recent clinical trial involving two EPFL entities — spin-off Amazentis and the Laboratory of Integrative Systems Physiology (LISP) — showed that urolithin A, a compound derived from biomolecules found in fruits such as pomegranates, could slow down this process by improving the functioning of mitochondria — the cells’ powerhouses. A joint paper presenting the results of the trial also demonstrates that ingesting the compound poses no risk to human health.

Slowing mitochondrial aging.

Liz Parrish, BioViva Sciences Inc CEO, chats with James Strole, Director of the Coalition for Radical Life Extension, about what she’s bringing to RAADfest 2019: gene therapies as regenerative treatments on human patients.

Hear what she has to share, and meet her at RAADfest 2019, October 3–6, Las Vegas, NV.

For more info and to register: http://www.raadfest.com/

https://www.prweb.com/releases/regenerage_international_iime…449142.htm

In a recent study, a group of researchers from Hebrew University-Hadassah Medical School, Feinberg School of Medicine, and Tel Aviv University examined astrocytes in mice and found that these cells exhibited a senescent phenotype that led to neurodegeneration and neurotoxicity [1].

Age-dependent increase in senescent astrocytes adjacent to Aβ plaques

Cellular senescence, discovered in 1961 by Leonard Hayflick and Paul Moorhead, is a state in which cells no longer perform their functions, instead emitting harmful chemicals that turn other cells senescent… These cells are caused primarily by telomere shortening and DNA damage, they are known to contribute to many diseases, and this is not the first study that links them to neurodegeneration.

The three-hour event was part marketing spectacle and part dry technical explainer. Musk and his team members described the brain-machine interface design they’re betting on, which will employ dozens of thin wires to collect signals in the brain, and which they want to try out on paralyzed people soon, so they can type with their minds. Their eventual aim is to connect those wires to a thought transmitter which tucks behind your ear like a hearing aid.

Well, it’s pretty cool. It seemed like maybe it will work the way they want down the road, but it probably doesn’t work that way now. A couple of years ago, when I heard he was working with a neural interface, I said I would be there in a heartbeat. I was joking, but it’s interesting to think about what I am going to do when I get explanted. I am coming up on my five years. Then the FDA says my implants may have to come out. Neuralink talked about longevity of the implant and also a large number of electrodes. I always say I wish they had put more electrodes into me.

Basically, the more electrodes you have, the more neurons you record from, so I would imagine higher-degree tasks would be easier. I am limited to thinking about my right arm and hand. I thought it would be good to have more control. I always want to play more video games.

Continue reading “Man with brain implant on Musk’s Neuralink: ‘I would play video games’” »

My mission is to drastically improve your life by helping you break bad habits, build and keep new healthy habits to make you the best version of yourself. I read the books and do all the research and share my findings with you!

This video is an interview of Dr. Aubrey de Grey @ SENS on July 17, 2019. My wife, Lauren Nally, was our camerawoman.

Continue reading “Brent Nally interviews Dr. Aubrey de Grey @ SENS on July 17, 2019” »

People with bones damaged by accidents, cancer or aging could one day benefit from bone grafts strengthened with chicken eggshells.

Researchers from Johns Hopkins University have published a new study that sheds light on skin rejuvenation, and it shares a link with what some cosmetic companies are doing using laser therapy.

A link between cosmetics and regeneration

During their study, the researchers found that the laser treatments used by cosmetic companies and retinoic acid, which is produced by the skin and sold commercially to treat wrinkles and sun damage, also target the same pathway. In addition, they also found that the activity of this pathway is increased in mice when they regenerate their hair follicles [1].