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Category: life extension – Page 393

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We’ve been raised with the belief that death is inevitable, and so during our lives we consider the legacy of what each of us leaves behind. But what if you had unlimited time to pursue your life’s work, your hobbies, and your dreams.

What if you didn’t have to die? As science and medicine advances, the average human lifespan continues to increase from better care and medicines that treat diseases. Some scientists say that in the near future, perhaps within the next 50 years, immortality might be within our grasp.

To begin to understand the aging process, we have to look at the laws of physics. There are four laws of thermodynamics, and the second law of thermodynamics basically implies that everything made up of atoms rusts, falls apart and disintegrates. We are all made of atoms, and those atoms must obey the second law of thermodynamics.

Currently there are drugs based on small molecules called senolytics which are designed to eliminate these zombie cells which refuse to die. This is a good thing, because such defective senescent cells persist to emit harmful chemicals that damage other healthy cells, and cause inflammation; a process that is one of the basic mechanisms of aging. But this is only a small part of the process.

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What if you could cheat death and live forever? To people in the radical life extension movement, immortality is a real possibility. Leah Green spends a long weekend at RAADfest, a meeting of scientists, activists and ordinary people who want to extend the human lifespan. So is reversing your age a real possibility? And what’s behind this wish to live forever?
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On this episode of Anti-Aging Hacks show, we get into the following topics:

1. What is Gene Therapy and how Practical is it?

2. How Gene Therapies or Gene Editing help you Stop Aging, Build Muscle and Fight Disease?

3. Could you take your body back to your much younger self?

My guest is Liz Parrish, and Liz is a humanitarian, entrepreneur, innovator, and a leading voice for genetic cures. As a strong proponent of progress and education for the advancement of regenerative medicine modalities, she serves as a motivational speaker to the public at large for the life sciences. She is actively involved in international educational media outreach and is a founding member of the International Longevity Alliance (ILA).

Here are the highlights from our conversation:

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Death means an end, but one recent research challenges the idea and fuels the possibility of reviving the brain. And it has plunged the scientific community into an ethical debate.

Physical movements, thoughts, and actions are traits that define how we know the difference between what’s alive and what’s lifeless i.e. death. But beyond that, we hardly understand what death means. We’ve known that death is an eventuality and irreversible. But recent research done back in April 2019 changed all that. Consequently, science is making us rethink the definition of death and the sheer fact that it is permanent.

A neuroscientist Christof Koch recently pondered over death in an article in the Scientific American. Koch wrote, “Death, this looming presence just over the horizon, is quite ill-defined from both a scientific as well as a medical point of view.”

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Albert Einstein’s famous expression “spooky action at a distance” refers to quantum entanglement, a phenomenon seen on the most micro of scales. But machine learning seems to grow more mysterious and powerful every day, and scientists don’t always understand how it works. The spookiest action yet is a new study of heart patients where a machine-learning algorithm decided who was most likely to die within a year based on echocardiogram (ECG) results, reported by New Scientist. The algorithm performed better than the traditional measures used by cardiologists. The study was done by researchers in Pennsylvania’s Geisinger regional healthcare group, a low-cost and not-for-profit provider.

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The tiny hydra, a freshwater invertebrate related to jellyfish and corals, has an amazing ability to renew its cells and regenerate damaged tissue. Cut a hydra in half, and it will regenerate its body and nervous system in a couple of days. Researchers at the University of California, Davis have now traced the fate of hydra’s cells, revealing how three lines of stem cells become nerves, muscles or other tissues.

Celina Juliano, assistant professor in the UC Davis Department of Molecular and Cellular Biology, project scientist Stefan Siebert and colleagues including Jeff Farrell, a postdoctoral researcher at Harvard University, sequenced the RNA transcripts of 25,000 single hydra cells to follow the genetic trajectory of nearly all differentiated cell types.

“The beauty of single-cell sequencing and why this is such a big deal for developmental biologists is that we can actually capture the genes that are expressed as cells differentiate from stem cells into their different cell types,” Juliano said.

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