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Transhumanist FAQ

The Transhumanist FAQ was developed in the mid-1990s and in 1998 became a formal FAQ through the inspirational work of transhumanists, including Alexander Chislenko, Max More, Anders Sandberg, Natasha Vita-More, Eliezer Yudkowsky, Arjen Kamphius, and many others. Greg Burch, David Pearce, and Anders Sandberg kindly offered extensive editorial comments. The presentation in the cryonics section was, and still is, directly inspired by an article by Ralph Merkle. Ideas, criticisms, questions, phrases, and sentences to the original version were contributed by (in alphabetical order): Alex ([email protected]), Brent Allsop, Brian Atkins, Scott Badger, Doug Bailey, Harmony Baldwin, Damien Broderick, Greg Burch, David Cary, John K Clark, Dan Clemensen, Damon Davis, Jeff Dee, Jean-Michel Delhotel, Dylan Evans, [email protected], Daniel Fabulich, Frank Forman, Robin Hanson, Andrew Hennessey, Tony Hollick, Joe Jenkins, William John, Michelle Jones, Arjen Kamphius, Henri Kluytmans, Eugene Leitl, Michael Lorrey, [email protected], Peter C. McCluskey, Erik Moeller, J. R. Molloy, Max More, Bryan Moss, Harvey Newstrom, Michael Nielsen, John S. Novak III, Dalibor van den Otter, David Pearce, [email protected], Thom Quinn, Anders Sandberg, Wesley R. Schwein, [email protected], Allen Smith, Geoff Smith, Randy Smith, Dennis Stevens, Derek Strong, Remi Sussan, Natasha Vita-More, Michael Wiik, Eliezer Yudkowsky, and [email protected].

Over the years, this FAQ has been updated to provide a substantial account of transhumanism. Extropy Institute (ExI) was a source of information for the first version of the Transhumanist FAQ, version 1.0 in the 1990s. The Transhumanist Manifesto, conceived by Natasha Vita-More in 1983 and revised in 1998–2020 to include advances of the growing worldview, was published in the CD placed onboard the Cassini-Huygens spacecraft in its mission to Saturn.

Humanity+, also known as WTA, adopted the FAQ in 2001 and Nick Bostrom added substantial information about future scenarios. With the contributions of close to hundred people from ExI, Aleph, DeTrans, Transcedo, WTA, and the UK Transhumanist Association, new material has been added and many old sections have been substantially reworked. In the preparation of version 2.0, the following people have been especially helpful: Eliezer Yudkowsky, who provided editorial assistance with comments on particular issues of substance; Dale Carrico who proofread the first half of the text; and Michael LaTorra who did the same for the second half; and “Reason” who then went over the whole document again, as did Frank Forman, and Sarah Banks Forman. Useful comments of either substance or form have also been contributed by (in alphabetical order): Michael Anissimov, Samantha Atkins, Milan Cirkovic, José Luis Cordeiro, George Dvorsky, James Hughes, G.E.

Combination of Rapamycin and Acarbose Extends Lifespan

28 to 34% lifespan increase in mice. I wonder if there would be side effects as a recent study showed Rapamycin and Metformin canceled each other’s side effects.


In a new study published in Aging Cell, researchers have tested several individual drugs and a combination of rapamycin plus acarbose as potential life extension agents in genetically heterogeneous mice [1].

Identification of successful anti-aging interventions is arguably one of the most challenging research problems to date. In addition to the complexity of aging, researchers have to deal with the biological heterogeneity of animals even within the same species and research reproducibility issues due to different experimental designs and approaches.

The National Institute on Aging Interventions Testing Program (ITP) was launched in 2004 with these limitations in mind. It is a peer-reviewed multi-institutional study evaluating potential lifespan-extending agents. The experiments are run in parallel at the Jackson Laboratory; the University of Michigan; and the University of Texas Health Science Center at San Antonio on genetically heterogeneous mice of both sexes.

Improve Lung Function, Reduce Blood Pressure, Slow Brain Aging?

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James Kirkland: Senolytics have a 20% chance of success

One of the hallmarks of aging, cellular senescence is what happens when aging cells do not die in the usual way (a process known as apoptosis) and start to accumulate in our bodies. The accumulation of these “senescent” cells is implicated in diseases including dementias, atherosclerosis, cancers, diabetes and arthritis. But senescence is not just part of the aging process – it tends to occur in individuals who develop frailty and multiple illnesses, and this can occur at any point during life.

In 2015, a team of researchers at the Mayo Clinic, led by Dr James L Kirkland, published a seminal paper in Aging Cell that introduced a new class of drugs called senolytics. Based on the idea that removing senescent cells may enhance human healthspan, these drugs were identified based on their ability to selectively target and eliminate those cells.

Longevity. Technology: Since the discovery of the first senolytics, hundreds of others have since been identified or created, and senotherapeutics is now one of the hottest areas in longevity, with a host of clinical trials under way and companies pursuing senolytic therapies for a range of age-related conditions. But what does the man who started it all think about the therapeutic field he helped create? In the first of two articles, we bring you Dr Kirkland’s unique perspective on the world of senolytics.

Aging is a complex, multidimensional, non-linear and widely misunderstood reversible process

This video is the 1st of a series of “What is Aging” webinars that aims to unravel what aging is, how we age, why we age, and how to reverse it.

We welcome Jason C. Mercurio, MFE, Dr. Jose Cordeiro, and Dr. Ian Hale to discuss the topic.

Thanks to our transhumanist influencers including:
@G. Stolyarov II @Ray Kurzweil 2017 @The Singularity is Near.
#ageless #agelesspartners #agereveal #longevity #biohacking #biotechnology #agingbackwards.

Book a coaching session with an Ageless Coach today:
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Live long and age less!

7 Lessons on Aging

“The idea was to build a society like we have for all the other disciplines in medicine,” says Evelyne Bischof, a professor of medicine at Shanghai University of Medicine and Health Sciences and the inaugural vice president of the society. She has previously spearheaded educational efforts with Zhavoronkov and others, co-developing a formal course on longevity medicine for doctors. At the ARDD meeting, Bischof announced their course had just received continuing medical education (CME) accreditation from the American Medical Association.

“Longevity medicine is crystallizing as a discipline,” says Andrea Maier, an internal medicine specialist and geriatrician at National University of Singapore who is serving as the society’s inaugural president. One thing that’s not yet clear, several experts told me, is whether longevity will come to be established as a sub-discipline of geriatrics or internal medicine or whether it will become a separate medical specialty unto itself.

“Whichever way it goes,” Maier says, “it’s happening.”

Prof. Dr. Andrea B. Maier, MD, PhD — Building A Clinically Credible Platform For Longevity Medicine

Building A Clinically Credible Platform For Longevity Medicine — Prof. Dr. Andrea Maier MD, PhD, National University of Singapore, Centre for Healthy Longevity.


Professor Dr. Andrea B. Maier, MD, Ph.D., is the Oon Chiew Seng Professor in Medicine, Healthy Ageing and Dementia Research, and Co-Director of the Centre for Healthy Longevity, at the National University Of Singapore (https://discovery.nus.edu.sg/19564-andrea-britta-maier).

Professor Maier also holds professorship appointments at VU University Medical Centre — https://research.vu.nl/en/persons/andrea-maier, Amsterdam, Netherlands, and University of Melbourne (https://findanexpert.unimelb.edu.au/profile/773728-andrea-maier), Australia, as well as is Director of Medicine and Community Care at the Royal Melbourne Hospital, Australia.

Professor Maier is also the President of the Australia and New Zealand Society for Sarcopenia and Frailty Research, as well as Founding President of the Healthy Longevity Medicine Society — https://hlms.co/.

A Fellow of the Royal Australasian College of Physicians (FRACP), Professor Maier graduated in Medicine (MD) 2003 from the University of Lübeck (Germany), was registered 2009 in The Netherlands as Specialist in Internal Medicine-Geriatrics and was appointed Full Professor of Gerontology at Vrije Universiteit Amsterdam (The Netherlands) in 2013 where she was the head of Geriatrics at the Vrije Universiteit Medical Center from 2012 to 2016.

The Aging Process Is Unstoppable, Or Is It…?

Just a matter of time for people.


Anti-Aging interview with David Sinclair by Mr. Myllet.

BY THE WAY…, I recently signed up for Dr. David Sinclair’s new test that will tell me how fast I’m aging — I thought you would want to know too!
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BI 103 Randal Koene and Ken Hayworth: The Road to Mind Uploading

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Free Video Series: Open Questions in AI and Neuroscience:

BI Workshop- Open Questions Ever

Show notes: https://braininspired.co/podcast/103/

Randal, Ken, and I discuss a host of topics around the future goal of uploading our minds into non-brain systems, to continue our mental lives and expand our range of experiences. The basic requirement for such a subtrate-independent mind is to implement whole brain emulation. We discuss two basic approaches to whole brain emulation. The “scan and copy” approach proposes we somehow scan the entire structure of our brains (at whatever scale is necessary) and store that scan until some future date when we have figured out how to us that information to build a substrate that can house your mind. The “gradual replacement” approach proposes we slowly replace parts of the brain with functioning alternative machines, eventually replacing the entire brain with non-biological material and yet retaining a functioning mind.
Randal and Ken are neuroscientists who understand the magnitude and challenges of a massive project like mind uploading, who also understand what we can do right now, with current technology, to advance toward that lofty goal, and who are thoughtful about what steps we need to take to enable further advancements.

Timestamps.
0:00 — Intro.
6:14 — What Ken wants.
11:22 — What Randal wants.
22:29 — Brain preservation.
27:18 — Aldehyde stabilized cryopreservation.
31:51 — Scan and copy vs. gradual replacement.
38:25 — Building a roadmap.
49:45 — Limits of current experimental paradigms.
53:51 — Our evolved brains.
1:06:58 — Counterarguments.
1:10:31 — Animal models for whole brain emulation.
1:15:01 — Understanding vs. emulating brains.
1:22:37 — Current challenges.

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