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After statins, the next leading class of medications for managing cholesterol are PCSK9 inhibitors. These highly effective agents help the body pull excess cholesterol from the blood, but unlike statins, which are available as oral agents, PCSK9 inhibitors can only be administered as injections, creating barriers to their use.

Longevity. Technology: Having high cholesterol can increase the risk of heart and circulatory diseases such as heart attack, stroke and vascular dementia, but a new study from investigators at University Hospitals (UH) and Case Western Reserve University School of Medicine details an orally administered small-molecule drug that reduces PCSK9 levels and lowers cholesterol in animal models by 70%. Published in Cell Reports, the findings represent a previously unrecognised strategy for managing cholesterol and may also impact cancer treatments.

Cardiovascular disease ranking as the world’s number one killer, so it’s no surprise that a significant amount of research into potential therapeutic options is ongoing; just last week we looked at Cyclarity’s rationally-designed cyclodextrin molecules that remove arterial plaque by clearing the non-degradable oxidised cholesterol and which can be used in conjunction with statins for a broad-spectrum approach. Our report into Cyclarity’s new platform comes out next week, so stay tuned!

Research from the Babraham Institute has developed a method to “time jump” human skin cells by 30 years, turning back the aging clock for cells without losing their specialized function. Work by researchers in the Institute’s Epigenetics research program has been able to partly restore the function of older cells, as well as rejuvenating the molecular measures of biological age. The research is published today in the journal eLife, and while this topic is still at an early stage of exploration, it could revolutionize regenerative medicine.

What is regenerative medicine?

As we age, our cells’ ability to function declines and the accumulates marks of aging. Regenerative biology aims to repair or replace cells including old ones. One of the most important tools in regenerative biology is our ability to create “induced” stem cells. The process is a result of several steps, each erasing some of the marks that make cells specialized. In theory, these stem cells have the potential to become any cell type, but scientists aren’t yet able to reliably recreate the conditions to re-differentiate stem cells into all cell types.

Talk kindly contributed by Michael Levin in SEMF’s 2022 Spacious Spatiality.

https://semf.org.es/spatiality.

TALK ABSTRACT
Life was solving problems in metabolic, genetic, physiological, and anatomical spaces long before brains and nervous systems appeared. In this talk, I will describe remarkable capabilities of cell groups as they create, repair, and remodel complex anatomies. Anatomical homeostasis reveals that groups of cells are collective intelligences; their cognitive medium is the same as that of the human mind: electrical signals propagating in cell networks. I will explain non-neural bioelectricity and the tools we use to track the basal cognition of cells and tissues and control their function for applications in regenerative medicine. I will conclude with a discussion of our framework based on evolutionary scaling of intelligence by pivoting conserved mechanisms that allow agents, whether designed or evolved, to navigate complex problem spaces.

TALK MATERIALS
· The Electrical Blueprints that Orchestrate Life (TED Talk): https://www.ted.com/talks/michael_levin_the_electrical_bluep…trate_life.
· Michael Levin’s interviews and presentations: https://ase.tufts.edu/biology/labs/levin/presentations/
· Michael Levin’s publications: https://ase.tufts.edu/biology/labs/levin/publications/
· The Institute for Computationally Designed Organisms (ICDO): https://icdorgs.org/

MICHAEL LEVIN
Department of Biology, Tufts University: https://as.tufts.edu/biology.
Tufts University profile: https://ase.tufts.edu/biology/labs/levin/
Wyss Institute profile: https://wyss.harvard.edu/team/associate-faculty/michael-levin-ph-d/
Wikipedia: https://en.wikipedia.org/wiki/Michael_Levin_(biologist)
Google Scholar: https://scholar.google.com/citations?user=luouyakAAAAJ
Twitter: https://twitter.com/drmichaellevin.
LinkedIn: https://www.linkedin.com/in/michael-levin-b0983a6/

SEMF NETWORKS

Dr. Dobri Kiprov about Therapeutic Plasma Exchange: New video from our 2022 #RejuvenationStartupSummit. Dobri is CSO at Lyfspn and an internationally renowned pioneer and expert in Therapeutic Apheresis, Immunotherapy, and Age-Related Disorders.

Enjoy -> https://lnkd.in/e_PZAsMm.

#plasmapherese #TPE #therapeuticplasmaexchange.

For more summit videos and regular updates, visit: https://lnkd.in/e-wSTtca


Dr. Dobri Kiprov, CSO at Lyfspn and internationally renowned pioneer and expert in Therapeutic Apheresis, Immunotherapy, and Age Related Disorders at Rejuvenation Startup Summit 2022.

The event, which was held at a luxury resort in the Swiss Alps last week, drew some of the world’s richest people along with some of its most controversial scientists.

Harvard Medical School genetics professor George Church, SENS Research Foundation chief of science offices Aubrey de Grey, Buck Institute for Research on Aging president and CEO Eric Verdin, Institute for Ageing Research at Albert Einstein College of Medicine director Nir Barzilai, Forever Healthy Foundation founder Michael Greve, Human Longevity Inc. associate professor, internal medicine Evelyne Yehudit Bischof, founder and CEO of Insilico Medicine Alex Zhavoronkov, creator of First Longevity and Longevity. Technology editor-in-chief Phil Newman, and Wei-Wu He, executive chairman of Human Longevity Inc., CEO and chairman of Casi Pharmaceuticals Inc., and founder and chairman of Genetron Health.

According to MIT Technology Review, Mega-Rich investors met with scientists and biotech founders in a swanky resort town of Gstaad, Switzerland, to advance the “longevity science,” which is a new field that could extend human life spans. The conference included some of the richest investors and entrepreneurs on earth.

Join us on Patreon!
https://www.patreon.com/MichaelLustgartenPhD

TruDiagnostic Discount Link (Epigenetic Testing)
CONQUERAGING!
https://bit.ly/3Rken0n.

Bristle Discount Link (Oral Microbiome Quantification):
ConquerAging15
https://www.bmq30trk.com/4FL3LK/GTSC3/

Quantify Discount Link (At-Home Blood Testing)
https://getquantify.io/mlustgarten.

Cronometer Discount Link (Daily Diet Tracking):
https://shareasale.com/r.cfm?b=1390137&u=3266601&m=61121&urllink=&afftrack=

If you’d like to support the channel, you can do that with the website.

Researchers at Harvard University are investigating whether human genes could reverse the effects of aging. NBC Medical Fellow Dr. Akshay Syal got exclusive access to their lab to discuss the future of how to defy aging.

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#NBCNews #Aging #Science

No questions concerning plasma dilution or E5, but a good interview with chapters.


Professor Matt Kaeberlein discusses the Dog Aging Project, longevity, Rapamycin, mTOR, and if we can ‘solve aging’

Timestamps:
0:00 Dog Aging Project.
4:18 Intermittent fasting.
10:23 Best longevity lifestyle.
16:25 Rapamycin & mTOR
23:27 Rapamycin human study.
30:18 Protein restriction diets.
39:46 Combination longevity therapies.
45:38 SGLT2i therapies.
47:23 Metformin & longevity.
52:50 Navigating misinformation.
55:28 Creatine.
59:00 Best exercises for longevity.
01:03:00 Can we solve aging?
01:09:45 Epigenetic reprogramming.
1:16:50 Supplements Dr Kaeberlein takes.

Donate towards our Rapamycin & Exercise clinical study: https://bit.ly/3QwugRx.

My full supplement stack: https://drstanfield.com/my-supplements/

Today we have the impression that our planet is a stable place, in exception of some natural disasters. But there was times earth was not a live-friendly place. A important condition for life is the presence of liquid water (maybe not everywhere). Land was inhabitated till the Ordovizium because of air Oxygen poverty.

Many Factors are changing the state of our planet. For first the sun which is increasing their radiation by ageing. This is evident because it shifts the inner bounder of the habitable zone away from sun. Another Problem is the ageing of earth and the decreasing of geological activities. This will reduce the exhaust of greenhouse gasses and so the outer border of habitable zone will shrink. Maybe after 500 Million years life on earth is no more possible, but just Pangea Ultimo will be a very hostile, deserted World. Later Water will evaporate, combinated with volcanic gases Earth will get a very dense athmosphere very Venus-like. This state will Keep for billions of year — a very sad end for our planet before Sun, after the collapse of hydrogen burning and a instable phase will finally inflate to a red giant. It’s not sure if earth will be absorbed but otherwise it would be a devastated, lonely planet travelling through space… Have you ideas for another Video — write it in the coments — best ideas will be realized… I also make gaming-Videos about Amazing-Frog and Minecraft, my Server https://minewind.com

Have you ideas for another Video — write it in the coments — best ideas will be realized…

I also make gaming-Videos about Amazing-Frog and Minecraft, my Server.

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