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A lot of anti-ageing vids lately. Good. This concerns Turn.bio. Though not in this vid, MH does have a habit of asking ‘When?” at some point. Previously Turn.bio said they have a first working treatment in just a few years so we’ll see what happens in vids to come of this interview.


In this video Professor Sebastiano introduces ERA, Epigenetic Reprogramming of Age technology and talks about his thoughts on some of the causes of aging.

Professor Vittorio Sebastiano manages a lab in Stanford University which developed and patented technology for partial cellular reprogramming. He co-founded Turn Bio, where he is now Head of research, to translate this technology into clinical applications. And with that, let me start the interview.

Turn Bio website.
https://www.turn.bio/
Professor Sebastiano’s lab at Stanford.
https://med.stanford.edu/stemcell/institutefaculty/sebastiano.html.
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells.
https://pubmed.ncbi.nlm.nih.gov/32210226/

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Patrick Burgermeister of KIZOO Technology Ventures presents at Investing in the Age of Longevity 2022. In his talk, Patrick gives an overview of KIZOO Technology Ventures’ investment strategy, with a particular focus on misson-driven investments in early stage companies that open new categories of treatment. Patrick showcases six biotech startups that form part of the company’s key investments: Cellvie, Revel, Cyclarity, LIfT BioSciences, Elastrin, and Mogling Bio.

Download the presentation slides: https://bit.ly/IAL22-Patrick-Burgermeister.

Investing in the Age of Longevity 2022 was held in London on 17 November 2022. The one-day masterclass featured presentations from scientists and business leaders at the cutting edge of the field, giving participants the inside track on the latest aging-related discoveries and investment opportunities.

Download the event programme: https://www.masterinvestor.co.uk/IAL22

Find out more about past and upcoming Master Investor events: https://events.masterinvestor.co.uk

Ray Kurzweil is an author, computer scientist, inventor, futurist and a director of engineering at Google. Kurzweil is a public advocate for the futurist and transhumanist movements, and gives public talks to share his optimistic outlook on life extension technologies and the future of nanotechnology, robotics, and biotechnology.

Recorded 2013

Aging inevitably increases the risk of disease, as exemplified by CAD, AD, and cancer. Monitoring the aging process and understanding its mechanisms will not only enhance early diagnoses, it may also provide strategies for the early prevention and treatment of diseases. While biomarkers for cellular senescence in in vitro cultured mammalian cells are already well-defined, those that define in vivo senescence/aging at the systemic level remain scarce. Here, we generated a targeted Glb1+/m allele at the Glb1 locus that encodes β-galactosidase. The GAC signal indicates Glb1 level. The results reveal that the live-imaged GAC signal is linearly correlated with chronological age, but only in middle-aged mice (9–13 months). High GAC at the MA stage was associated with cardiac hypertrophy and shortened lifespan. Moreover, GAC signal was exponentially increased in pathological lung fibrosis induced by BLM. Thus, this in vivo reporter mouse can faithfully monitor systemic aging and organ functional decline in a manner closely associated with lifespan, and provides an ideal system for studying aging mechanisms and developing anti-aging manipulations.

The upregulation of p16Ink4a transcription and elevated SAβ-gal staining are both well-established and widely used biomarkers for cellular senescence17, and the former led to the generation of live-imaging aging reporter mice20,22,23. Intriguingly, high level of p16Ink4a, indicated by luciferase activity, predicts cancer initiation rather than lifespan. Similarly, the in vivo application of SAβ-gal as a senescence marker at the tissue level is also limited. Positive SAβ-gal-staining is easy to obtain in kidney and adipose tissue sections but difficult to obtain in blood vessel and heart sections. By SAβ-gal staining, not many positive cells were detected in old individuals26. It raises the question of whether SAβ-gal labels in vivo senescence or if the percentage of in vivo senescent cells is indeed very low.

New advances in medical science may improve health of older people and extend lift, perhaps just long enough for more advanced future therapies.#longevity #health #healthspan What is the next step and how can we combine different therapies and test if we can rejuvenate an adult mouse, and humans?Our guest speaker Aubrey de Grey present what may come next.

If you wish to check the links to the sites mentioned in the discussion: https://www.levf.orghealthspanaction.orga4li.orglessdeath.orgTo donate to Longevity Escape Velocity Foundation (LEVF) and to the rejuvenation research:

https://www.levf.org/

This is a followup trial result to the first trial that reported 2.5 years of epigenetic age reversal This has interesting reports from the actual patients about how they feel and the changes it made to them. After the first trial I sent an email to see if I could do this but I have IBS which Fahy said would disqualify me.


Dr. Greg Fahy gives an update on the TRIIM-X clinical trial at EARD 2022.

The TRIIM-X clinical trial aims to understand how to create a personalized thymus regeneration regimen. By regenerating the thymus, the researchers hope to be able to prevent or reverse certain aspects of immune system aging.

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Age-related macular degeneration (AMD) is the most common cause of vision loss among people aged 50 and older, affecting an estimated 7.3 million individuals in the United States. Of these patients, 1.75 million have advanced AMD and will lose vision from this condition. This includes patients with the “wet” form of AMD, characterized by the growth of abnormal blood vessels in the retina that can bleed or leak damaging fluids into the central portion of this light-sensing tissue.

“Our goal is to re-regulate all of your genes back to an earlier state.” Excellent. Hurry please. I’m 51.


Magnesium Break Through 10% Discount https://bit.ly/3O5tPfu.
This video brought to you by BiOptimizers.

In this video Dr Davidsohn discusses the next generation therapies that Rejuvenate Bio are working on. We also discuss, klotho, RJB02 and his personal protocol.

Dr Noah Davidsohn is a founder and Chief Scientific Officer of Rejuvenate Bio a company developing gene therapies to treat aging and age related diseases.

Rejuvenate Bio website.

One of the world’s leading hospitals is preparing to offer longevity clinical services to patients. Sheba Medical Center in Tel Aviv, Israel, is poised to open a dedicated longevity centre in 2023, with the goal of democratising the extension of healthy lifespan for the masses.

Longevity. Technology: While research, development and investment in longevity are at an all-time high, the implementation of longevity clinical practice in mainstream healthcare is virtually non-existent. While private clinical practices are now making longevity services accessible to those who can afford it, the societal benefit of improving healthspan can only be realised if everyone can access it. To learn more, we caught up with Professor Tzipi Strauss, Director of Neonatology at Sheba Hospital, who is the driving force behind the new centre.

It may seem curious that a paediatrician is the instigator of an initiative focused on improving aging, but Strauss explains that the relevance of longevity begins at birth.