Lifeboat Foundation

Many of the all-too-familiar symptoms of aging can be attributed to a build-up of senescent cells, those which have stopped dividing. In a new study, researchers in Japan have identified a protein specific to these cells and developed a vaccine that can clear them away, with tests on mice reducing the effects of aging.

Cells cannot keep dividing forever – eventually they accumulate too much DNA damage through environmental stress, so the body shuts them down and flags them to be cleared out by the immune system. This seems to be an evolutionary defense mechanism against cells turning cancerous.

However, even immune cells aren’t immune from this process, and as they become senescent themselves the immune system gradually loses the ability to clear out senescent cells. As these inactive cells accumulate in the body, they contribute to symptoms of aging and the diseases that come with it.

First known for their link with longevity, sirtuins play a key role in maintaining a cell’s integrity in light of metabolic and environmental damage.

“The change in life expectancy is significant, when you consider that an equivalent jump in human life expectancy would have us living on average until almost 120,” lead researcher Haim Cohen of Bar-Ilan University told the Times of Israel.

A longer life: The average human life expectancy has doubled in just the past 200 years, thanks in no small part to scientific breakthroughs in medicine, nutrition, and disease.

A study explores how supplementing with a compound produced by gut bacteria when digesting foods such as pomegranates could help reverse muscle aging.

Building resilience for healthy aging — dr. charlotte yeh, MD, chief medical officer, AARP services.

Dr Charlotte Yeh, MD Chief Medical Officer, AARP Services, Inc. (https://www.aarp.org/about-aarp/aarp-services/), where she works with the independent carriers that make health-related products and services available to AARP members, to identify programs and initiatives that will lead to enhanced care for older adults.

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Papers referenced in the video:
Main study:
Clinical course of the longest-lived man in the world: A case report.
https://pubmed.ncbi.nlm.nih.gov/34973348/

Continue reading “Supercentenarian (112 — 116y) Blood Test Analysis” »

A study cohort that received an oral supplement of a gut-produced compound had better endurance in two small exercises.

An oral supplement intended to stimulate a natural body process appears to promote muscle endurance and mitochondrial health in humans. New research suggests that the supplement, urolithin A, may help improve or prolong muscle activity in people who are aging or who have diseases that make exercise difficult.

The paper was published in JAMA Network Open.

“Remembering that you are going to die is the best way I know to avoid the trap of thinking you have something to lose.” Steve Jobs.

Do you agree? I think baring in mind you only have 1 life to live can embolden you to take chances you may have otherwise ignored. But I think *valuing* this life can help you want to preserve it and prevent you from taking unnecessary risks.

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Startups are betting that partial reprogramming with Yamanaka factors may lead to age reversal, but hurdles remain.