Time to reverse your age and restore youth.
Scientists at a San Diego-based biotech company Rejuvenate Bio claim to have increased the age of mice by reprogramming their genes. They believe their gene therapy actually works like a reverse aging technique that one day might be used for rejuvenating humans.
Their lifespan increased by about seven percent after the introduction of the genes.
𝐁𝐫𝐚𝐢𝐧 𝐀𝐫𝐞𝐚 𝐍𝐞𝐜𝐞𝐬𝐬𝐚𝐫𝐲 𝐟𝐨𝐫 𝐅𝐥𝐮𝐢𝐝 𝐈𝐧𝐭𝐞𝐥𝐥𝐢𝐠𝐞𝐧𝐜𝐞 𝐈𝐝𝐞𝐧𝐭𝐢𝐟𝐢𝐞𝐝 — 𝐃𝐞𝐟𝐢𝐧𝐢𝐧𝐠 𝐅𝐞𝐚𝐭𝐮𝐫𝐞 𝐨𝐟 𝐇𝐮𝐦𝐚𝐧 𝐂𝐨𝐠𝐧𝐢𝐭𝐢𝐨𝐧
𝘼 𝙩𝙚𝙖𝙢 𝙡𝙚𝙙 𝙗𝙮 𝙐𝙣𝙞𝙫𝙚𝙧𝙨𝙞𝙩𝙮 𝘾𝙤𝙡𝙡𝙚𝙜𝙚 𝙇𝙤𝙣𝙙𝙤𝙣 (𝙐𝘾𝙇) 𝙖𝙣𝙙 𝙐𝙣𝙞𝙫𝙚𝙧𝙨𝙞𝙩𝙮 𝘾𝙤𝙡𝙡𝙚𝙜𝙚 𝙇𝙤𝙣𝙙𝙤𝙣 𝙃𝙤𝙨𝙥𝙞𝙩𝙖𝙡𝙨 (𝙐𝘾𝙇𝙃) 𝙧𝙚𝙨𝙚𝙖𝙧𝙘𝙝𝙚𝙧𝙨 𝙝𝙖𝙨 𝙢𝙖𝙥𝙥𝙚𝙙 𝙩𝙝𝙚 𝙥𝙖𝙧𝙩𝙨 𝙤𝙛 𝙩𝙝𝙚 𝙗𝙧𝙖𝙞𝙣 𝙩𝙝𝙖𝙩 𝙨𝙪𝙥𝙥𝙤𝙧𝙩 𝙤𝙪𝙧 𝙖𝙗𝙞𝙡𝙞𝙩𝙮 𝙩𝙤 𝙨𝙤𝙡𝙫𝙚 𝙥𝙧𝙤𝙗𝙡𝙚𝙢𝙨 𝙬𝙞𝙩𝙝𝙤𝙪𝙩 𝙥𝙧𝙞𝙤𝙧 𝙚𝙭𝙥𝙚𝙧𝙞𝙚𝙣𝙘𝙚 — 𝙤𝙩𝙝𝙚𝙧𝙬𝙞𝙨𝙚 𝙠𝙣𝙤𝙬𝙣 𝙖𝙨 𝙛𝙡𝙪𝙞𝙙 𝙞𝙣𝙩𝙚𝙡𝙡𝙞𝙜𝙚𝙣𝙘𝙚. 𝙁𝙡𝙪𝙞𝙙 𝙞𝙣𝙩𝙚𝙡𝙡𝙞𝙜𝙚𝙣𝙘𝙚 𝙞𝙨 𝙖𝙧𝙜𝙪𝙖𝙗𝙡𝙮 𝙩𝙝𝙚 𝙙𝙚𝙛𝙞𝙣𝙞𝙣𝙜 𝙛𝙚𝙖𝙩𝙪𝙧𝙚 𝙤𝙛 𝙝𝙪𝙢𝙖𝙣 𝙘𝙤𝙜𝙣𝙞𝙩𝙞𝙤𝙣. 𝙄𝙩 𝙥𝙧𝙚𝙙𝙞𝙘𝙩𝙨 𝙚𝙙𝙪𝙘𝙖𝙩𝙞𝙤𝙣𝙖𝙡 𝙖𝙣𝙙 𝙥𝙧𝙤𝙛𝙚𝙨𝙨𝙞𝙤𝙣𝙖𝙡 𝙨𝙪𝙘𝙘𝙚𝙨𝙨, 𝙨𝙤𝙘𝙞𝙖𝙡 𝙢𝙤𝙗𝙞𝙡𝙞𝙩𝙮, 𝙝𝙚𝙖𝙡𝙩𝙝, 𝙖𝙣𝙙 𝙡𝙤𝙣𝙜𝙚𝙫𝙞𝙩𝙮. 𝙄𝙩 𝙖𝙡𝙨𝙤 𝙘𝙤𝙧𝙧𝙚𝙡𝙖𝙩𝙚𝙨 𝙬𝙞𝙩𝙝 𝙢𝙖𝙣𝙮 𝙘𝙤𝙜𝙣𝙞𝙩𝙞𝙫𝙚 𝙖𝙗𝙞𝙡𝙞𝙩𝙞𝙚𝙨 𝙨𝙪𝙘𝙝 𝙖𝙨 𝙢𝙚𝙢𝙤𝙧𝙮.
A team led by University College London (UCL) and University College London Hospitals (UCLH) researchers has mapped the parts of the brain that support our ability to solve problems without prior experience – otherwise known as fluid intelligence.
Fluid intelligence is arguably the defining feature of human cognition. It predicts educational and professional success, social mobility, health, and longevity. It also correlates with many cognitive abilities such as memory.
Nearly half of people worldwide do not get the recommended daily total water intake, a new report indicates.
Yet drinking enough water may help to delay the aging process for many.
A recent study by the National Institutes of Health (NIH) published in eBioMedicine suggests as much — though there are caveats to know.
A team of researchers affiliated with multiple institutions in Canada has found that obesity in young mice can lead to inflammatory disease later in life even if the mouse is no longer overweight. In their paper published in the journal Science, the group describes studying early life obesity in test mice and the development of age-related macular degeneration. Kevin Mangum and Katherine Gallagher with the University of Michigan have published a Perspectives piece in the same journal issue outlining the research.
Age-related macular degeneration (AMD) in older people can lead to permanent blindness. Prior research has shown obesity plays a major role in its development. Other research has also shown that AMD is a neuroinflammatory condition. It is believed that the inflammation in the eyes is related to obesity, but the exact connection has not been identified. In this new effort, the researchers sought to find the connection by studying obesity and macular degeneration in mice.
The work involved feeding test mice a high-fat diet and studying the impact on adipose tissue macrophages (types of white blood cells that are part of the immune system). They found that obesity in mice led to epigenetic changes in the macrophages that resulted in an increase in expression of genes that incite an inflammatory response. They also found that the increased expression continued even after the test mice were put on a reduced diet that allowed them to return to their normal weight.
Experts are worried the world’s richest billionaires, including Elon Musk and Jeff Bezos, will be able to stave off aging and use their immense wealth to live longer than any human being has before.
Bookmark
The transport of mercury ions across intestinal epithelial cells can be studied for toxicology assessments by using animal models and static cell cultures. However, the concepts do not reliably replicate conditions of the human gut microenvironment to monitor in situ cell physiology. As a result, the mechanism of mercury transport in the human intestine is still unknown.
In a new report now published in Nature Microsystems and Nanoengineering, Li Wang and a research team in mechanical engineering and regenerative medicine in China developed a gut-on-a-chip instrument integrated with transepithelial electrical resistance (TEER) sensors and electrochemical sensors.
They proposed to explore the dynamic concept to simulate the physical intestinal barrier and mirror biological transport and adsorption mechanisms of mercury ions. The scientists recreated the cellular microenvironment by applying fluid shear stress and cyclic mechanical strain.
Powered by data produced by its AI-driven discovery platform, clinical-stage biotech BioAge Labs is rapidly developing a pipeline of therapies to extend healthy lifespan by targeting the molecular causes of aging. Having raised more than $120 million in funding, and with multiple clinical trials already under its belt, the company is focused on building a broad pipeline of potential longevity therapies in three main areas: muscle, immune, and brain aging.
Longevity. Technology: There are few companies in the longevity biotech field that appear to be executing on their vision as quickly and consistently as BioAge. When the company wowed the sector with a $90 million funding round in 2020, talk of multiple imminent clinical trials may have sounded optimistic to some, but BioAge has delivered on its promise time and again. Beyond the trials already underway, the company’s much-vaunted AI discovery platform also appears to be churning out the data, this year spawning a new programme exploring the potential of NLRP3 inhibitors in brain aging. To learn more, we caught up with BioAge co-founder and CEO Kristen Fortney.
Looking back at 2022, Fortney says it has been “immensely gratifying” to see so many new companies and investors coming into the longevity field.
Posted in biological, life extension
Aging appears to progress similarly across species, from worms and flies to mice and humans, and involves pathways related to early development. Guest Linda Partridge talks with Gordon while visiting the Buck Institute to discuss the evolutionary trade offs of aging mechanisms, the role of nutrient-sensing pathways, and how we might get the most benefit from preventative interventions in midlife.
Linda Partridge, born in 1950 in Bath, England, studied and graduated in biology at the University of Oxford. After three years of postdoctoral research at the University of York, she was Demonstrator, Lecturer, Reader and finally Professor at the University of Edinburgh. After many years in Scotland, in 1994 she became Professor of Biometry, University College London. She is both a founding director of the new Max Planck Institute for Biology of Ageing in Cologne and Director of the UCL Institute of Healthy Ageing. Linda Partridge’s research is directed to understanding both how the rate of aging evolves in nature and the mechanisms by which healthy lifespan can be extended in laboratory model organisms. Her work has focussed in particular on the role of nutrient-sensing pathways, such as the insulin/insulin-like growth factor signaling pathway, and on dietary restriction.
