Lifeboat Foundation

Summary: Oleic acid produced in the brain is an essential regulator of processes that enable memory, learning, and mood regulation. Oleic acid, which is abundant in olive oil, also promoted neurogenesis and increases cell proliferation.

Source: Baylor College of Medicine.

Many people dread experiencing the cognitive and mood declines that often accompany reaching an advanced age, including memory disorders such as Alzheimer’s disease and mood conditions like depression.

Rejuvenation biotechnology: good progress, but a long way still to go.

Cryonicists hope that modern technology will one day bring them back from the dead. But how realistic is a second life after a deep freeze?

This disparity gets at the difference between one’s chronological age — how old they are in years — and their biological age, which is how their body has aged naturally and in response to its environment. The two can diverge in ways that are either blessings or curses. Hence why those who grow up under extreme stress or in polluted environments may look much older than they actually are.

And yellow-bellied marmots can tell us something about these two ages.

Yellow-bellied marmots (Marmota flaviventer) are no burrow-dwelling meteorologists like the groundhog. They may sound craven, but these quirky critters, also known as whistle pigs, make for fascinating subjects: the cat-sized rodents have a longer lifespan than expected for a mammal of their size. On average, marmots live 15 years.

A little confusing. Cure aging in 20 years but you’re not a longevity company?

Altos Labs recently exited stealth mode to announce $3 billion in funding, reportedly from investors including Jeff Bezos, and a team full of Nobel Prize winners and pioneering scientists. However, the secretive company’s representatives insist that “Altos is not an anti-aging or longevity company”. Despite this, a key member of their scientific leadership recently publicly stated that he is convinced that, using the same technologies they are working with at Altos, we will be able to prevent aging within twenty years.

Continue reading “Prevent Aging within 20 Years? — Altos Labs’ Cellular Reprogramming Excitement” »

How Jeff Bezos and Altos Labs are challenging death itself: The science of partial cellular reprogramming!

Hey it’s Han from WrySci-HX going over the science behind Altos Labs (the biotech company looking to extend healthspan and lifespan), news from the cultured meat industry, developments on a new device that can change your skin into nerve cells, and other science / technology happenings! More below ↓↓↓

Continue reading “Altos Labs Explained: Jeff Bezos’ $3 Billion Gamble to Live Forever [Science Update March 2022]” »

Summary: Body temperature exerts a greater effect on longevity and lifespan than metabolic rate, researchers report.

Source: Chinese Academy of Sciences.

Researchers from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences, along with collaborators from Wenzhou University and the University of Aberdeen, have found that body temperature exerts a greater effect on lifespan than metabolic rate.

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Levine’s Biological age calculator is embedded as an Excel file in this link from my website:
https://michaellustgarten.com/2019/09/09/quantifying-biological-age/

Senolytics are an emerging class of drugs designed to target zombie-like cells that have stopped dividing and build up in the body as we age, and the past few years have seen some exciting discoveries that demonstrate their potential. Adding another to the list are Mayo Clinic researchers, who have shown that these drugs can protect against aging and its related diseases, by acting on a protein long associated with longevity.

The zombie-like cells involved in this research are known as senescent cells, and their accumulation during aging is associated with a range of diseases. Recent studies have shown that using senolytics to clear them out could serve as new and effective treatments for dementia and diabetes, and also improve health and lifespan more broadly.

The Mayo Clinic team were exploring how senolytics can influence levels of a protein called a-klotho, known to help protect older people from the effects of aging. The role of this protein in the aging process is well established and has placed it at the center of much research in this space, with studies demonstrating how it could help reverse osteoarthritis and regenerate old muscles.